Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jerry M. Buysse"'
Autor:
Gbur Randi K, Nguyen Son H, Jerry M. Buysse, Kalpesh Biyani, Paul H. Kierstead, Jun Shao, Matthew J. Kade, Gerrit Klaerner, Tabakman Scott M
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 375(3)
Current management of metabolic acidosis in patients with chronic kidney disease (CKD) relies on dietary intervention to reduce daily endogenous acid production or neutralization of retained acid with oral alkali (sodium bicarbonate, sodium citrate).
Publikováno v:
J Am Soc Nephrol
Retrospective analyses and single-center prospective studies identify chronic metabolic acidosis as an independent and modifiable risk factor for progression of CKD. In patients with CKD, untreated chronic metabolic acidosis often leads to an acceler
Autor:
Claire Lockey, Robert J. Alpern, Yuri Stasiv, Jerry M. Buysse, Thomas H. Hostetter, Angela Lee, David A. Bushinsky, Elizabeth Li, Gerrit Klaerner, Sarah McNulty, Dawn Parsell, Vandana Mathur
Publikováno v:
Clinical Journal of the American Society of Nephrology. 13:26-35
Background and objectives Metabolic acidosis is common in patients with CKD and has significant adverse effects on kidney, muscle, and bone. We tested the efficacy and safety of TRC101, a novel, sodium-free, nonabsorbed hydrochloric acid binder, to i
Publikováno v:
Clin J Am Soc Nephrol
BACKGROUND AND OBJECTIVES: Metabolic acidosis is associated with progression of CKD and has significant adverse effects on muscle and bone. A systematic review and meta-analysis was conducted to evaluate the benefits and risks of metabolic acidosis t
Autor:
M. Jamie T.V. Cope, Lawrence Lee, Faleh Salaymeh, Stephen D. Harrison, Lance Berman, Jerry M. Buysse, Craig Park, Wade W. Benton, Lingyun Li, Deidre Madsen
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics
Hyperkalemia is a potentially life-threatening condition, and patients who have chronic kidney disease, who are diabetic, or who are taking renin–angiotensin–aldosterone system inhibitors are at increased risk. Therapeutic options for hyperkalemi
Publikováno v:
Future Cardiology. 8:17-28
The treatment of heart failure has seen considerable advances in the past decades. In particular, a therapeutic focus on the renin–angiotensin–aldosterone system has provided significant improvements in outcomes. Multiple inhibition points in the
Autor:
Jerry M. Buysse
Publikováno v:
Frontiers in Medicinal Chemistry - Online. 1:529-542
Autor:
Keith R. Marotti, Earline P. Melchior, Steve M. Swaney, William F. Demyan, Dean L. Shinabarger, Donna S. Dunyak, Jerry M. Buysse, Alice H. Lin, Robert W. Murray
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:2132-2136
The oxazolidinones are a new class of synthetic antibiotics with good activity against gram-positive pathogenic bacteria. Experiments with a susceptible Escherichia coli strain, UC6782, demonstrated that in vivo protein synthesis was inhibited by bot
Autor:
Betty H. Yagi, Suzanne E. Glickman, Susan K. Hendges, Ford Charles W, Toops Dana S, Jonda D. Schaadt, Barbachyn Michael R, Douglas Stapert, Kevin C. Grega, Jerry M. Buysse, Judith C. Hamel, James O. Kilburn, Gary E. Zurenko, William F. Demyan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1009-1014
Various electron-withdrawing groups were incorporated into the meta position of tropone-substituted 3-phenyl-2-oxazolidinones and their influence on antibacterial activity examined. Consideration of in vitro and in vivo test results indicated that on
Autor:
Jerry M. Buysse, Martha H. Mulks
Publikováno v:
Gene. 165:61-66
We describe methods for the mutagenesis of cloned Actinobacillus pleuropneumoniae (Ap) genes and for the construction of Ap mutants by allelic exchange. We used these methods to construct isogenic mutants of Ap which no longer synthesized a 48-kDa ou