Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Jerry M Parks"'
Autor:
Benjamin Russell Lewis, Muhammad R. Uddin, Mohammad Moniruzzaman, Katie M. Kuo, Anna J. Higgins, Laila M. N. Shah, Frank Sobott, Jerry M. Parks, Dietmar Hammerschmid, James C. Gumbart, Helen I. Zgurskaya, Eamonn Reading
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system from Escherichia coli, AcrAB-TolC, is a target for inhibition to lessen resistance development and restore antibiotic effi
Externí odkaz:
https://doaj.org/article/db36206389534e89aa35837123b7295a
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background In a previous paper, we classified populated HLA class I alleles into supertypes and subtypes based on the similarity of 3D landscape of peptide binding grooves, using newly defined structure distance metric and hierarchical clust
Externí odkaz:
https://doaj.org/article/e4d13c8451d94829a094ab17984ee4ec
Autor:
Brian C. Sanders, Suman Pokhrel, Audrey D. Labbe, Irimpan I. Mathews, Connor J. Cooper, Russell B. Davidson, Gwyndalyn Phillips, Kevin L. Weiss, Qiu Zhang, Hugh O’Neill, Manat Kaur, Jurgen G. Schmidt, Walter Reichard, Surekha Surendranathan, Jyothi Parvathareddy, Lexi Phillips, Christopher Rainville, David E. Sterner, Desigan Kumaran, Babak Andi, Gyorgy Babnigg, Nigel W. Moriarty, Paul D. Adams, Andrzej Joachimiak, Brett L. Hurst, Suresh Kumar, Tauseef R. Butt, Colleen B. Jonsson, Lori Ferrins, Soichi Wakatsuki, Stephanie Galanie, Martha S. Head, Jerry M. Parks
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mamma
Externí odkaz:
https://doaj.org/article/fd261a622e08487782f550c5d0f5bc31
Autor:
Debjani Pal, Kuntal De, Carly M. Shanks, Kai Feng, Timothy B. Yates, Jennifer Morrell-Falvey, Russell B. Davidson, Jerry M. Parks, Wellington Muchero
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are essential for HGF/c-MET signaling and regulate their interaction, perinuclear localization, and cellular internalization. Thus, targeting PAN may represent a mechanism for the
Externí odkaz:
https://doaj.org/article/6723ce81c6c14178bfb99e772c5987d5
Autor:
Inga V. Leus, Jon W. Weeks, Vincent Bonifay, Yue Shen, Liang Yang, Connor J. Cooper, Dinesh Nath, Adam S. Duerfeldt, Jeremy C. Smith, Jerry M. Parks, Valentin V. Rybenkov, Helen I. Zgurskaya
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Two membrane cell envelopes act as selective permeability barriers in Gram-negative bacteria, protecting cells against antibiotics and other small molecules. Significant efforts are being directed toward understanding how small molecules per
Externí odkaz:
https://doaj.org/article/c8beeb71c6274a14889057ff8ee519e0
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Accurate descriptions of protein-protein interactions are essential for understanding biological systems. Here the authors present AF2Complex and show that application to the E. coli cytochrome biogenesis system I yields confident computational model
Externí odkaz:
https://doaj.org/article/292112ae49f04dfdb35777d29f8cb011
Autor:
Inga V. Leus, Jon W. Weeks, Vincent Bonifay, Yue Shen, Liang Yang, Connor J. Cooper, Dinesh Nath, Adam S. Duerfeldt, Jeremy C. Smith, Jerry M. Parks, Valentin V. Rybenkov, Helen I. Zgurskaya
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2f4f4b54ca034d91a0ffcca607143010
Autor:
Suthee Rapisuwon, Benjamin Izar, Cory Batenchuk, Alexandre Avila, Shaolin Mei, Peter Sorger, Jerry M. Parks, Sarah J. Cooper, David Wagner, Jay C. Zeck, Aline J. Charabaty, Michael B. Atkins
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-6 (2019)
Abstract Balancing the potential for durable remissions with autoimmune-like toxicities is a key clinical challenge in the use of immune checkpoint inhibitors (ICI). Certain toxicities are associated with an increased response rate; however, the mole
Externí odkaz:
https://doaj.org/article/f54d4a4c5a99413cb4ff1d081d85c30a
Autor:
Steven Dajnowicz, Ryne C. Johnston, Jerry M. Parks, Matthew P. Blakeley, David A. Keen, Kevin L. Weiss, Oksana Gerlits, Andrey Kovalevsky, Timothy C. Mueser
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Pyridoxal 5’-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, among them aspartate aminotransferase. Here the authors use neutron crystallography, which allows the visualization of the positions of hydrogen atoms, and computation to c
Externí odkaz:
https://doaj.org/article/3f5fbae599884609a7b1076b862da5d3
Autor:
Caitlin M. Gionfriddo, Ally Bullock Soren, Ann M. Wymore, D. Sean Hartnett, Mircea Podar, Jerry M. Parks, Dwayne A. Elias, Cynthia C. Gilmour
Publikováno v:
Appl Environ Microbiol
The hgcAB gene pair encodes mercury (Hg) methylation capability in a diverse group of microorganisms, but its evolution and transcriptional regulation remain unknown. Working from the possibility that the evolutionary function of HgcAB may not be Hg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec3abcdedd9aec41ecd6d3f8f11e5f1
https://doi.org/10.1128/aem.01768-22
https://doi.org/10.1128/aem.01768-22