Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Jerry L Campbell"'
Autor:
Ali A. Rostami, Jerry L. Campbell, Yezdi B. Pithawalla, Hamideh Pourhashem, Raheema S. Muhammad-Kah, Mohamadi A. Sarkar, Jianmin Liu, Willie J. McKinney, Robinan Gentry, Maria Gogova
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Physiologically based pharmacokinetic (PBPK) modeling can be a useful tool for characterizing nicotine pharmacokinetics (PK) from use of tobacco products. We expand a previously published PBPK model to simulate a nicotine PK profile, followi
Externí odkaz:
https://doaj.org/article/30402a91565447e0a0d12ad30d1ac0c2
Autor:
Rory P. Conolly, Harvey J. Clewell, Martha M. Moore, Jerry L. Campbell, Wanyun Cheng, R. Robinan Gentry
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA.Methods: Model development was supported by read across
Externí odkaz:
https://doaj.org/article/d8f7461641fa4ee682ebb9ff72cdf343
Autor:
Ali A. Rostami, Jerry L. Campbell, Yezdi B. Pithawalla, Hamideh Pourhashem, Raheema S. Muhammad-Kah, Mohamadi A. Sarkar, Jianmin Liu, Willie J. McKinney, Robinan Gentry, Maria Gogova
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/45206e653006461698478f0987a342c5
Autor:
Rory B, Conolly, Jerry L, Campbell, Harvey J, Clewell, Jeffry, Schroeter, Julia S, Kimbell, P Robinan, Gentry
Publikováno v:
Toxicological Sciences. 191:15-24
Understanding the dose-response for formaldehyde-induced nasal cancer in rats is complicated by (1) the uneven distribution of inhaled formaldehyde across the interior surface of the nasal cavity and, (2) the presence of endogenous formaldehyde (endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde6602d72d410cbfe9162760058e888
https://doi.org/10.1093/toxsci/kfac119
https://doi.org/10.1093/toxsci/kfac119
Autor:
Jerry L Campbell, Harvey J Clewell, Cynthia Van Landingham, P Robinan Gentry, Athena M Keene, Michael D Taylor, Melvin E Andersen
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology.
In earlier physiologically based pharmacokinetic (PBPK) models for manganese (Mn), the kinetics of transport of Mn into and out of tissues were primarily driven by slow rates of association and dissociation of Mn with tissue binding sites. However, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ef7816aef3f1c7f85d4097bbbdfcd0
https://pubmed.ncbi.nlm.nih.gov/36453847
https://pubmed.ncbi.nlm.nih.gov/36453847
Autor:
Allison Franzen, Melvin E. Andersen, Miyoung Yoon, P.R. Gentry, Jerry L. Campbell, Harvey J. Clewell, Darol E. Dodd, C. Van Landingham
Publikováno v:
Inhalation Toxicology. 32:369-371
Kaltofen and colleagues criticize our use of the rate of production of epoxides per unit lung volume as the dose metric when we used a PBPK model of chloroprene to provide risk assessments for lung...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::135b68aea2cbf6b789c98beaa48aa83b
https://doi.org/10.1080/08958378.2020.1817199
https://doi.org/10.1080/08958378.2020.1817199
Publikováno v:
Toxicological Sciences
Although formaldehyde is a normal constituent of tissues, lifetime inhalation exposures at 6 h/day, 5 days/week at concentrations ≥6 ppm caused a nonlinear increase in nasal tumors in rats with incidence reaching close to 50% at 15 ppm. Studies wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2767343959b77f5519d5ed75e540ba2f
https://pubmed.ncbi.nlm.nih.gov/32735340
https://pubmed.ncbi.nlm.nih.gov/32735340
Autor:
Miyoung Yoon, Rebecca A. Clewell, Chantel I. Nicolas, Jerry L. Campbell, Jeremy A. Leonard, Harvey J. Clewell, Alina Efremenko, Melvin E. Andersen, Yu-Mei Tan, Katherine Phillips, Patrick D. McMullen
Publikováno v:
Toxicol In Vitro
Advancements in measurement and modeling capabilities are providing unprecedented access to estimates of chemical exposure and bioactivity. With this influx of new data, there is a need for frameworks that help organize and disseminate information on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860210bee5556db4f1820d5500e0bd42
https://europepmc.org/articles/PMC8204916/
https://europepmc.org/articles/PMC8204916/
Autor:
Jerry L. Campbell, Yi-Hsien Cheng, Wei-Chun Chou, H.J. Clewell, Tammie R. Covington, A.Y. Efremenko, Corie A. Ellison, Jeffrey W. Fisher, Jeffery M. Gearhart, C.E. Hack, Sami Haddad, N. Hewitt, Conrad Housand, Shruti V. Kabadi, Miao Li, Zhoumeng Lin, Darshan Mehta, A. Najjar, Andy Nong, S.N. Pendse, Christopher Ruark, A. Schepky, Lisa M. Sweeney, Xiaoxia Yang, Miyoung Yoon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a68691a9f72220a2cc6093218841c0a4
https://doi.org/10.1016/b978-0-12-818596-4.00019-9
https://doi.org/10.1016/b978-0-12-818596-4.00019-9
Accounting for metabolism in a physiologically based pharmacokinetic (PBPK) model is important from a pharmacokinetics perspective. Hepatic and extrahepatic enzymatic biotransformations occur across species and are usually dependent upon age and perh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0b0dfd87edb7615f221b38c12227854
https://doi.org/10.1016/b978-0-12-818596-4.00007-2
https://doi.org/10.1016/b978-0-12-818596-4.00007-2