Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jerry J. Fan"'
Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes
Autor:
Xian Wang, Zheyuan Gong, Tiancong Wang, Junhui Law, Xin Chen, Siyi Wanggou, Jintian Wang, Binbin Ying, Michelle Francisco, Weifan Dong, Yi Xiong, Jerry J. Fan, Graham MacLeod, Stephane Angers, Xuejun Li, Peter B. Dirks, Xinyu Liu, Xi Huang, Yu Sun
Publikováno v:
Science Advances. 9
Glioblastoma (GBM) is the most common and aggressive primary brain cancer. Despite multimodal treatment including surgery, radiotherapy, and chemotherapy, median patient survival has remained at ~15 months for decades. This situation demands an outsi
Autor:
Jerry J. Fan, Xin Wang, Anders W. Erickson, Patryk Skowron, Xian Wang, Xin Chen, Guanqiao Shan, Shahrzad Bahrampour, Yi Xiong, Weifan Dong, Namal Abeysundara, Michelle A. Francisco, Ronwell J. Pusong, Raúl A. Suárez, Hamza Farooq, Borja L. Holgado, Xiaochong Wu, Craig Daniels, Adam J. Dupuy, Juan Cadiñanos, Allan Bradley, Anindya Bagchi, Branden S. Moriarity, David A. Largaespada, A. Sorana Morrissy, Vijay Ramaswamy, Stephen C. Mack, Livia Garzia, Peter B. Dirks, Siyi Wanggou, Xuejun Li, Yu Sun, Michael D. Taylor, Xi Huang
The identification of cancer maintenance genes—driver genes essential to tumor survival—is fundamental for developing effective cancer therapy. Transposon-based insertional mutagenesis screens can identify cancer driver genes broadly but not disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5898806babf946d74e7c455fe6da428
https://doi.org/10.1101/2022.07.23.501234
https://doi.org/10.1101/2022.07.23.501234
Autor:
Xin Chen, Ali Momin, Siyi Wanggou, Xian Wang, Hyun-Kee Min, Wenkun Dou, Zheyuan Gong, Jade Chan, Weifan Dong, Jerry J. Fan, Yi Xiong, Kamilia Talipova, Hongyu Zhao, Yuki X. Chen, Kelly Veerasammy, Adam Fekete, Sachin A. Kumar, Hongwei Liu, Qi Yang, Joe Eun Son, Zhengchao Dou, Malini Hu, Parnian Pardis, Kyle Juraschka, Laura K. Donovan, Jiao Zhang, Vijay Ramaswamy, Hayden J. Selvadurai, Peter B. Dirks, Michael D. Taylor, Lu-Yang Wang, Chi-chung Hui, Rinat Abzalimov, Ye He, Yu Sun, Xuejun Li, Xi Huang
Publikováno v:
Neuron. 111(1)
Major obstacles in brain cancer treatment include the blood-tumor barrier (BTB), which limits the access of most therapeutic agents, and quiescent tumor cells, which resist conventional chemotherapy. Here, we show that Sox2
Autor:
Jerry J, Fan, Xi, Huang
Publikováno v:
Reviews of physiology, biochemistry and pharmacology. 183
Ion channels are pore-forming transmembrane proteins that govern ion flux to regulate a myriad of biological processes in development, physiology, and disease. Across various types of cancer, ion channel expression and activity are often dysregulated
Autor:
Xi Huang, Jerry J. Fan
Publikováno v:
Reviews of Physiology, Biochemistry and Pharmacology ISBN: 9783031039935
Ion channels are pore-forming transmembrane proteins that govern ion flux to regulate a myriad of biological processes in development, physiology, and disease. Across various types of cancer, ion channel expression and activity are often dysregulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae1425aeea3f7f7950230bc1aad2166
https://doi.org/10.1007/112_2020_48
https://doi.org/10.1007/112_2020_48
Autor:
Zheyuan Gong, Peter B. Dirks, Zhengchao Dou, Sachin Kumar, Lu-Yang Wang, Ali Momin, Yu Sun, Adam Fekete, Jerry J. Fan, Wenkun Dou, Ye He, Chi-chung Hui, Malini Hu, Hyun-Kee Min, Weifan Dong, Yuki X. Chen, Rinat R. Abzalimov, Parnian Pardis, Xin Chen, Kyle Juraschka, Jade Chan, Michael D. Taylor, Kelly Veerasammy, Xi Huang, Gousiyi Wang, Xian Wang, Laura Donovan, Xuejun Li
Publikováno v:
Neuro-Oncology. 23:vi26-vi26
Two major obstacles in brain cancer treatment are the blood-tumor barrier (BTB), which restricts delivery of most therapeutic agents, and the quiescent brain tumor-initiating cells (BTICs), which evade cell cycle-targeting chemotherapy. Mechanosensat
Autor:
Rochelle F. McAdam, Vijay Ramaswamy, Xuejun Li, Marian Sia, Michael D. Taylor, Xin Chen, Hyun-Kee Min, Michelle A Francisco, Ali Momin, Siyi Wanggou, Weifan Dong, Ronwell J. Pusong, Shixuan Liu, Noriyuki Kijima, Xi Huang, Jerry J. Fan, Namal Abeysundara, Jade Chan, Yuanquan Song, Lu-Yang Wang, Ran Kafri, Nish Patel
Publikováno v:
The Journal of Experimental Medicine
Francisco et al. show that chloride intracellular channel 1 (CLIC1) is an evolutionarily conserved regulator of brain tumor growth in Drosophila and medulloblastoma mouse models. CLIC1 cooperates with potassium channels to regulate cell volume homeos
Autor:
Xi Huang, Ankur Bodalia, Yuanquan Song, Fiona J. Coutinho, Wen Chi Yin, Feng Li, Xin Chen, Malini Hu, Lu-Yang Wang, Diana Draghici, Michelle Kushida, Yu Sun, Heather Whetstone, Weifan Dong, Jerry J. Fan, Wenkun Dou, Xuejun Li, Peter B. Dirks, Siyi Wanggou, Chi-chung Hui, Min Zhu, Hyun-Kee Min
Publikováno v:
Neuron. 100(4)
Summary Alteration of tissue mechanical properties is a physical hallmark of solid tumors including gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here, we show that mechanosensitive ion channel Piezo regulates mitos
Publikováno v:
Neuro-Oncology. 21:ii109-ii109
Medulloblastoma (MB) is the most common pediatric brain tumor. Current treatment modalities are aggressive and highly toxic to the developing brain, and survivors are left with long term cognitive defects and reduced quality of life. Furthermore, int
Autor:
Hans J. Leutheusser, Jerry J. Fan
Publikováno v:
Journal of Hydraulic Engineering. 127:514-517
This paper describes an experimental investigation of submerged hydraulic jumps forming downstream of overflow structures. Submergence happens when the hydrological tailwater depth in a channel exc...