Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Jerry H. Wang"'
Autor:
Jacques Hugon, Fanny C.F. Ip, Jun Wan, Amy K.Y. Fu, Jerry H. Wang, Zhenguo Wu, Guylène Page, Kwok On Lai, Nancy Y. Ip, Ho Keung Ng
Publikováno v:
The Journal of Neuroscience. 30:6873-6881
One of the pathological hallmarks of Alzheimer's disease (AD) is deposition of extracellular amyloid-β (Aβ) peptide, which is generated from the cleavage of amyloid precursor protein (APP). Accumulation of Aβ is thought to associate with the progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a9789bd0831f0100788fe8b70e44a5
https://doi.org/10.1523/jneurosci.0519-10.2010
https://doi.org/10.1523/jneurosci.0519-10.2010
Publikováno v:
Biochemical and Biophysical Research Communications. 317:128-132
As key regulators of the cell proliferation cycle, cyclin-dependent kinases (CDKs) are attractive targets for the development of anti-tumor drugs. In the present study, harmine was identified from a collection of herbal compounds to be a specific inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74765a27a38d118384ff3d6a4ccd8dd5
https://doi.org/10.1016/j.bbrc.2004.03.019
https://doi.org/10.1016/j.bbrc.2004.03.019
Publikováno v:
Nature Neuroscience. 6:1039-1047
CA1 pyramidal neurons degenerate after transient forebrain ischemia, whereas neurons in other regions of the hippocampus remain intact. Here we show that in rat hippocampal CA1 neurons, forebrain ischemia induces the phosphorylation of the N-methyl-D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ba0a5d48085cc9ccf04eafc62fb4d0
https://doi.org/10.1038/nn1119
https://doi.org/10.1038/nn1119
Publikováno v:
Journal of Biological Chemistry. 278:11760-11767
Mammalian STE20-like kinase 2 (MST2), a member of the STE20-like kinase family, has been shown in previous studies to undergo proteolytic activation by caspase-3 during cell apoptosis. A few studies have also implicated protein phosphorylation reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e585929bea688c720fb1e5eacfd57e2
https://doi.org/10.1074/jbc.m211085200
https://doi.org/10.1074/jbc.m211085200
Publikováno v:
Journal of Neurochemistry. 64:2681-2690
Neurofilament (NF) protein [high molecular mass (NF-H)] is extensively phosphorylated in vivo. The phosphorylation occurs mainly in its characteristic KSP (Lys-Ser-Pro) repeat motifs. There are two major types of KSP motifs in the NF-H tail domain: K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9304ac910b2cae04d9e699796a8b92
https://doi.org/10.1046/j.1471-4159.1995.64062681.x
https://doi.org/10.1046/j.1471-4159.1995.64062681.x
Publikováno v:
Journal of Neurochemistry. 69:845-850
Calmodulin-dependent cyclic nucleotide phosphodiesterase (CaMPDE) is one of the key enzymes involved in the complex interaction between the cyclic nucleotide and Ca2+ second-messenger systems. CaMPDE exists as tissue-specific isozymes, and initially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c845eae5f97a9449541c13566f93cb
https://doi.org/10.1046/j.1471-4159.1997.69020845.x
https://doi.org/10.1046/j.1471-4159.1997.69020845.x
Publikováno v:
Journal of Biological Chemistry. 277:15237-15240
Neuronal Cdc2-like kinase (Nclk) plays an important role in a variety of cellular processes, including neuronal cell differentiation, apoptosis, neuron migration, and formation of neuromuscular junction. The active kinase consists of a catalytic subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c2ffa2f2b3d1f82213e25aa8347065
https://doi.org/10.1074/jbc.c200032200
https://doi.org/10.1074/jbc.c200032200
Publikováno v:
Journal of Biological Chemistry. 277:7324-7332
The neuronal Cdk5 kinase is composed of the catalytic subunit Cdk5 and the activator protein p35 nck5a or its isoform, p39 nck5ai . To identify novel p35 nck5a - and p39 nck5ai -binding proteins, fragments of p35 nck5a and p39 nck5ai were utilized in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::075f35aa0c91aef7871f75790195cf8e
https://doi.org/10.1074/jbc.m107270200
https://doi.org/10.1074/jbc.m107270200
Autor:
Rajendra K. Sharma, Raju V. S. Rajala, Raju Datla, Jerry H. Wang, Svein A. Carlsen, Zhong Qi, Deborah H. Anderson
Publikováno v:
Biochemical and Biophysical Research Communications. 288:233-239
N-Myristoyltransferase (NMT) is an essential eukaryotic enzyme that catalyzes the cotranslational and/or posttranslational transfer of myristate to the amino terminal glycine residue of a number of important proteins especially the non-receptor tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787b5d56b62d5e0f860b9e7b91fc8607
https://doi.org/10.1006/bbrc.2001.5758
https://doi.org/10.1006/bbrc.2001.5758
Publikováno v:
Biochemical and Biophysical Research Communications. 285:77-83
Although Cdk5 shows high sequence identity to Cdk1 and Cdk2, it can be fully activated by its neuronal activators p35/p25(nck5a) and p39(nck5ai) in a phosphorylation-independent manner. To understand structural basis of the Cdk5/p25(nck5a) activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d267795cebf3a719691e09e92f7a26
https://doi.org/10.1006/bbrc.2001.5086
https://doi.org/10.1006/bbrc.2001.5086