Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Jerry E. Stewart"'
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Market, Michael E. Erwin, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 47, Iss , Pp 102045- (2024)
Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults. Trametinib is a kinase inhibitor that targets MEK1/2 and has been
Externí odkaz:
https://doaj.org/article/0515712cdd0f4633a52a9cf06e81c2dc
Autor:
Janet R. Julson, Colin H. Quinn, Swatika Butey, Michael H. Erwin, Raoud Marayati, Nazia Nazam, Jerry E. Stewart, Elizabeth A. Beierle
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 427 (2023)
Hepatoblastoma is the most common primary pediatric liver tumor. Children with pulmonary metastases at diagnosis experience survival rates as low as 25%. We have shown PIM kinases play a role in hepatoblastoma tumorigenesis. In this study, we assesse
Externí odkaz:
https://doaj.org/article/a3f45a9f17b6401fa93a28ebe0eb5e6e
Autor:
Raoud Marayati, Laura L. Stafman, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Joshua C. Anderson, Christopher D. Willey, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Despite increasing incidence, treatment for hepatoblastoma has not changed significantly over the past 20 years. Chemotherapeutic strategies continue to rely on cisplatin, as it remains the most active single agent against hepatoblastoma. Ho
Externí odkaz:
https://doaj.org/article/651d99d3286c48f987b6b07498bbc8c8
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Markert, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, David K. Crossman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101099- (2021)
Patient-derived xenografts provide significant advantages over long-term passage cell lines when investigating efficacy of treatments for solid tumors. Our laboratory encountered a high-grade, metastatic, neuroendocrine-like tumor from a pediatric pa
Externí odkaz:
https://doaj.org/article/ba8c4f5263934279a3ed4ec995b89d8c
Autor:
Adele P. Williams, Evan F. Garner, Laura L. Stafman, Jamie M. Aye, Colin H. Quinn, Raoud Marayati, Jerry E. Stewart, Venkatram R. Atigadda, Elizabeth Mroczek-Musulman, Blake P. Moore, Elizabeth A. Beierle, Gregory K. Friedman
Publikováno v:
Translational Oncology, Vol 12, Iss 10, Pp 1364-1374 (2019)
PURPOSE: In spite of advances in therapy for some subtypes, group 3 medulloblastoma continues to portend a poor prognosis. A subpopulation of medulloblastoma cells expressing the cell surface marker CD133 have been posited as possible stem cell like
Externí odkaz:
https://doaj.org/article/798dcfd1d04e44b4aa17ab1120ac63b9
Autor:
Laura L. Stafman, Adele P. Williams, Raoud Marayati, Jamie M. Aye, Hooper R. Markert, Evan F. Garner, Colin H. Quinn, Shoeb B. Lallani, Jerry E. Stewart, Karina J. Yoon, Kimberly Whelan, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Patient-derived xenografts (PDXs) provide an opportunity to evaluate the effects of therapies in an environment that more closely resembles the human condition than that seen with long-term passage cell lines. In the current studies, we inve
Externí odkaz:
https://doaj.org/article/ae4c4e6cac14422ea46500505cb9f16e
Autor:
Laura L. Stafman, Adele P. Williams, Evan F. Garner, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Kimberly Whelan, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 12, Iss 2, Pp 200-208 (2019)
Hepatoblastoma is the most common primary liver tumor in children, but treatment has not changed significantly in the past 20 years. We have previously demonstrated that Proviral Integration site for Moloney murine leukemia (PIM) kinases promote tumo
Externí odkaz:
https://doaj.org/article/50eba423670a4f4380c1edd4eb9fdaa0
Autor:
Adele P. Williams, Evan F. Garner, Alicia M. Waters, Laura L. Stafman, Jamie M. Aye, Hooper Markert, Jerry E. Stewart, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 12, Iss 1, Pp 84-95 (2019)
High-risk neuroblastoma continues to carry a poor prognosis. Nearly 50% of these tumors relapse following extensive treatment regimens. Protein phosphatase 2A (PP2A), a tumor suppressor, has been shown to be downregulated in many human cancers via mu
Externí odkaz:
https://doaj.org/article/e301bf95fdb34b2097d8ae0defd2aedc
Autor:
Raoud Marayati, Laura V. Bownes, Laura L. Stafman, Adele P. Williams, Colin H. Quinn, Venkatram Atigadda, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100893- (2021)
Retinoic acid (RA) therapy has been utilized as maintenance therapy for high-risk neuroblastoma, but over half of patients treated with RA relapse. Neuroblastoma stem cell-like cancer cells (SCLCCs) are a subpopulation of cells characterized by the e
Externí odkaz:
https://doaj.org/article/e246226acc30403d9cd1e402f31f9618
Autor:
Evan F. Garner, Adele P. Williams, Laura L. Stafman, Jamie M. Aye, Elizabeth Mroczek-Musulman, Blake P. Moore, Jerry E. Stewart, Gregory K. Friedman, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Group 3 tumors account for 28% of medulloblastomas and have the worst prognosis. FTY720, an immunosuppressant currently approved for treatment of multiple sclerosis, has shown antitumor effects in several human cancer cell lines. We hypothes
Externí odkaz:
https://doaj.org/article/60d3b17a2b504ab498e8b0462588e830