The evolution of Bordetella pertussis has selected for mutations of acr that lead to sensitivity to hydrophobic molecules and fatty acids

Autor: Iain MacArthur, Thomas Belcher, Jerry D. King, Vasantha Ramasamy, Munirah Alhammadi, Andrew Preston

Publikováno v: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 603-612 (2019)

ABSTRACTWhooping cough, or pertussis, is resurgent in numerous countries worldwide. This has renewed interest in Bordetella pertussis biology and vaccinology. The in vitro growth of B. pertussis has been a source of difficulty, both for the study of

Externí odkaz: https://doaj.org/article/096f26d16e5e4a198c4e2ed01fd0d093

Fundamental differences in physiology of Bordetella pertussis dependent on the two-component system Bvg revealed by gene essentiality studies

Autor: Matthew Mayho, Gemma C. Langridge, Thomas Belcher, Jerry D. King, Iain MacArthur, Andrew Preston, Julian Parkhill

Publikováno v: Belcher, T, MacArthur, I, King, J, Langridge, G, Mayho, M, Parkhill, J & Preston, A 2020, ' Fundamental differences in physiology of Bordetella pertussis dependent on the two-component system Bvg, revealed by gene essentiality studies. ', Microbial Genomics, vol. 6, no. 12, mgen000496 . https://doi.org/10.1099/mgen.0.000496
Microbial Genomics

The identification of genes essential for a bacterium’s growth reveals much about its basic physiology under different conditions. Bordetella pertussis , the causative agent of whooping cough, adopts both virulent and avirulent states through the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4d117f3b521af11e6c7032983901b1
https://nrl.northumbria.ac.uk/id/eprint/45198/1/mgen000496.pdf

Lipopolysaccharide O antigen size distribution is determined by a chain extension complex of variable stoichiometry in E scherichia coli O9a

Autor: Bradley R. Clarke, Chris Whitfield, Scott Berry, Jerry D. King, Richard J. Morris

Publikováno v: Proceedings of the National Academy of Sciences. 111:6407-6412

The lengths of bacterial polysaccharides can be critical for their biological function. Unlike DNA or protein synthesis, where polymer length is implicit in the nucleic acid template, the molecular mechanisms for regulating polysaccharide length are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619eaf0a5d7e0f88841de5a6c5a1efaa
https://doi.org/10.1073/pnas.1400814111

Review: Lipopolysaccharide biosynthesis inPseudomonas aeruginosa

Autor: Jerry D. King, Joseph S. Lam, Erin L. Westman, Dana Kocíncová

Publikováno v: Innate Immunity. 15:261-312

Pseudomonas aeruginosa causes serious nosocomial infections, and an important virulence factor produced by this organism is lipopolysaccharide (LPS). This review summarizes knowledge about biosynthesis of all three structural domains of LPS — lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3dc44c530727b83fe480a9545e02776
https://doi.org/10.1177/1753425909106436

lfnA from Pseudomonas aeruginosa O12 and wbuX from Escherichia coli O145 Encode Membrane-Associated Proteins and Are Required for Expression of 2,6-Dideoxy-2-Acetamidino- l -Galactose in Lipopolysaccharide O Antigen

Autor: Evgeny Vinogradov, Erin F. Mulrooney, Kristen Mead, Jerry D. King, Joseph S. Lam, Bernd Kneidinger

Publikováno v: Journal of Bacteriology. 190:1671-1679

The rare sugar 2,6-dideoxy-2-acetamidino- l -galactose ( l -FucNAm) is found only in bacteria and is a component of cell surface glycans in a number of pathogenic species, including the O antigens of Pseudomonas aeruginosa serotype O12 and Escherichi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d60947dbc3a327c86d9d35eb40cb51b2
https://doi.org/10.1128/jb.01708-07