Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jerry Cohen"'
Publikováno v:
Stress Biology. 2
Temperature, water, and light are three abiotic stress factors that have major influences on plant growth, development, and reproduction. Plants can be primed by a prior mild stress to enhance their resistance to future stress. We used an untargeted
Publikováno v:
Phytochemistry. 200:113219
Auxin is a key regulator of plant development and in Arabidopsis thaliana can be synthesized through multiple pathways; however, the contributions of various biosynthetic pathways to specific developmental processes are largely unknown. To trace the
Autor:
T. F. Holzman, Uri S. Ladror, Kenneth Jarvis, Hing L. Sham, Mark G. Anderson, Shi-Chung Ng, Le Wang, David Frost, Luis E. Rodriguez, Saul H. Rosenberg, Steven W. Muchmore, John E. Harlan, Jerry Cohen, Debra Ferguson, Yi-Chun Wang, Paul E. Kroeger, Vincent S. Stoll, Gerard M. Sullivan, Ingrid B J K Joseph, Nan-Horng Lin, Wen-Zhen Gu, Haiying Zhang, Clarissa G. Jakob, Kennan C. Marsh, Karl A. Walten
Publikováno v:
Anti-Cancer Drugs. 16:1059-1069
Ras mutation has been detected in approximately 20-30% of all human carcinomas, primarily in pancreatic, colorectal, lung and bladder carcinomas. The indirect inhibition of Ras activity by inhibiting farnesyltransferase (FTase) function is one therap
Autor:
Thomas J. Sowin, Wang Xilu, Steve O’Conner, Lisa A. Hasvold, Wen-Zhen Gu, Hing L. Sham, Jerry Cohen, Gary T. Wang, Robert Gentiles, Haiying Zhang, Charles W. Hutchins, Gerry Sullivan, Weibo Wang, Saul H. Rosenberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:153-158
A non-methionine FT inhibitor lead structure ( 1 ) was designed through computer modeling of the peptidomimetic FT inhibitor ABT839. Optimization of this lead resulted in compounds 2e and 2g , with FT IC 50 values of 1.3 and 1.8 nM, GGT IC 50 of 1400
Autor:
Saul H. Rosenberg, Le Wang, Wang Xilu, Jerry Cohen, Hing L. Sham, Nan-Horng Lin, Wen-Zhen Gu, Haiying Zhang, Gary T. Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5057-5062
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogs of the potent FTI, 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole, were synthesized and tested in vitro for their inhibitory activities. The most pro
Autor:
Hing L. Sham, Le Wang, Wen-Zhen Gu, Saul A. Rosenberg, Jerry Cohen, Haiying Zhang, Nan-Horng Lin, David Frost
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3821-3825
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anticancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for thei
Autor:
Hing L. Sham, Lisa A. Hasvold, Jerry Cohen, Weibo Wang, Yunsong Tong, Wen-Zhen Gu, Qun Li, Joy Bauch, Saul H. Rosenberg, Tongmei Li, Nicholas M Leonard, Le Wang, Vincent S. Stoll, Haiying Zhang, Nan-Horng Lin, Kennan C. Marsh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1571-1574
A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.
Autor:
David Frost, Wen-Zhen Gu, Jerry Cohen, Nan-Horng Lin, Hing L. Sham, Le Wang, Saul H. Rosenberg, Haiying Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1293-1296
Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for the
Autor:
Jerry Cohen, Shi Chung Ng, Dave Janowick, Hing L. Sham, Daniel A. Dickman, Saul H. Rosenberg, Peter Kovar, Steve Tahir, Robert B. Warner, Haichao Zhang, Sajeev Cherian, David J. Augeri, Badr Saeed, Gerry Sullivan, Douglas Kalvin, Jang Lee, Hong Ding, John J. Larsen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1069-1074
Potent and orally bioavailable nonthiol-containing inhibitors of protein farnesyltransferase are described. Oral bioavailability was achieved by replacement of the pyridyl ether moiety of 1 with a 2-substituted furan ether to give 4. Potency was rega
Autor:
Gerry Sullivan, Shi-Chung Ng, Sajeev Cherian, Jerry Cohen, Stephen J. O'Connor, Bruce G. Szczepankiewicz, Saul H. Rosenberg, John J. Larsen, Badr Saeed, Dave Janowick, Edward Devine, Haichao Zhang, Douglas Kalvin, David J. Augeri
Publikováno v:
Journal of Medicinal Chemistry. 41:4288-4300
Potent and selective non-thiol-containing inhibitors of protein farnesyltransferase are described. FTI-276 (1) was transformed into pyridyl ether analogue 19. The potency of pyridyl ether 19 was improved by modification of the biphenyl core to that o