Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jerry D. Clark"'
Autor:
Shahram Salek-Ardakani, John C. Lin, Arvind Rajpal, Eugenia Kraynov, Jeffrey Chou, Jerry D. Clark, Allison Xu, Christopher P. Dillon, Natalija Budimir, Brent Kern, Bart Jessen, Cris Kamperschroer, Sherman M. Chin, Christopher R. Kimberlin, Joyce Chou, HoangKim Nguyen, Yasmina Abdiche, Sawsan Youssef, Amir A. Al-Khami
Supplementary Figure 10 shows the selectivity of sasanlimab binding to human and cynomolgus monkey PD-1 using HEK-293T transiently transfected cells and flow cytometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570baa904bc39c4217dce06d7f70f261
https://doi.org/10.1158/1535-7163.22521613.v1
https://doi.org/10.1158/1535-7163.22521613.v1
Autor:
Shahram Salek-Ardakani, John C. Lin, Arvind Rajpal, Eugenia Kraynov, Jeffrey Chou, Jerry D. Clark, Allison Xu, Christopher P. Dillon, Natalija Budimir, Brent Kern, Bart Jessen, Cris Kamperschroer, Sherman M. Chin, Christopher R. Kimberlin, Joyce Chou, HoangKim Nguyen, Yasmina Abdiche, Sawsan Youssef, Amir A. Al-Khami
Development of antagonistic mAbs that specifically target the immune checkpoint receptor, programmed cell death protein-1 (PD-1), is of great interest for cancer immunotherapy. Here, we report the biophysical characteristics and nonclinical antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a605a4f9fbc692ff14dc6e0fb35295da
https://doi.org/10.1158/1535-7163.c.6543064
https://doi.org/10.1158/1535-7163.c.6543064
Autor:
Brent Kern, Yasmina Noubia Abdiche, Allison Xu, HoangKim Nguyen, Eugenia Kraynov, Christopher R. Kimberlin, Shahram Salek-Ardakani, Cris Kamperschroer, Sherman M. Chin, Amir A. Al-Khami, Arvind Rajpal, Joyce Chou, Jerry D. Clark, Christopher P. Dillon, Natalija Budimir, Jeffrey Chou, John C. Lin, Bart Jessen, Sawsan Youssef
Publikováno v:
Molecular cancer therapeutics. 19(10)
Development of antagonistic mAbs that specifically target the immune checkpoint receptor, programmed cell death protein-1 (PD-1), is of great interest for cancer immunotherapy. Here, we report the biophysical characteristics and nonclinical antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaaf940e92fb19cee9bbd6d8474bf04
https://pubmed.ncbi.nlm.nih.gov/32847983
https://pubmed.ncbi.nlm.nih.gov/32847983
Publikováno v:
Journal of Electronic Materials. 43:863-867
We have developed instrumentation for collecting the luminescence spectrum from solid samples while they are irradiated by electrons of sufficient energy to produce point defects. This instrumentation is used to investigate the evolution of the broad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c0596d320dd055dc4a15b6bc6cc33f
https://doi.org/10.1007/s11664-014-3066-9
https://doi.org/10.1007/s11664-014-3066-9
Autor:
A. F. Almagri, Jerry D. Clark, P. J. Bonofiglo, S. H. Sears, Jan Egedal, W. Capecchi, Jay Anderson, Juhyung Kim
Publikováno v:
The Review of scientific instruments. 87(11)
A fast ion loss detector has been constructed and implemented on the Madison Symmetric Torus (MST) to investigate energetic ion losses and transport due to energetic particle and MHD instabilities. The detector discriminates particle orbits solely on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9344d411c48de4e5015a5c75638476
https://pubmed.ncbi.nlm.nih.gov/27910492
https://pubmed.ncbi.nlm.nih.gov/27910492
Autor:
Ajit S. Shah, Thomas Rogers, James Murphy, Bruce E. Wise, D. Keith Anderson, Harish K. Santhanam, Mark A. Pietz, H. Peter Kleine, Derek B. Brown, V. H. Iskos, Jerry D. Clark, Melissa K. Lantz, Christine M. V. Moore, David V. Banaszak, Peter G. Ruminski, Czyzewski Ann M, Carlos A. Orihuela, Puneh S. Forouzi, Carl M. Knable, Gerald A. Weisenburger, Frank W. Muellner, Mark A. Lapack, Schilke Tobin C, Donald J. Gallagher, Albert D. Edeny, Ahmad Y. Sheikh
Publikováno v:
Organic Process Research & Development. 13:1088-1093
Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent approach is detailed wherein tetrahydropyrimidine hydroxybenzoic acid 2 is linked to the β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::733dff69b6ebf02a64d61a4be7a9b658
https://doi.org/10.1021/op900173f
https://doi.org/10.1021/op900173f
Autor:
Edney Albert D, Carl M. Knable, Puneh S. Karbin, Mark A. Pietz, D. Keith Anderson, Jerry D. Clark, Gerald A. Weisenburger, Donald J. Gallagher
Publikováno v:
Organic Process Research & Development. 13:60-63
The process development of a peptide coupling with CDI is discussed. Various solvents, addition orders, stoichiometries, and reaction temperatures were investigated. A reliable crystallization procedure was also developed. The new process was piloted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fac081742f6e05a791de8ebfe6610e
https://doi.org/10.1021/op8002213
https://doi.org/10.1021/op8002213
Autor:
Mike Hawksworth, Derek L. Tickner, Richard W. Barnhart, Ying Kang, Brian Moon, Stephen M. Shaw, Taber Geraldine Patricia, Paul Higginson, David J. Dale, Jerry D. Clark, Gerald A. Weisenburger, Donald J. Knoechel
Publikováno v:
Organic Process Research & Development. 11:1112-1125
The heat of reaction is an important parameter in the safe, successful scale-up of chemical processes. Reaction heat data is used to calculate the potential adiabatic temperature rise of the desire...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7e55b4b6c0025cc33fdccda53b3fed9
https://doi.org/10.1021/op700173h
https://doi.org/10.1021/op700173h
Publikováno v:
Organic Process Research & Development. 8:571-575
Studies directed toward the process research and development of a scalable method for preparing tetrahydropyrimidine 2, a key intermediate to the αvβ3 integrin antagonist 1, are described. A linear approach employing 3-amino-5-hydroxybenzoic acid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e51ecd058d17a4721b0649981a0c54
https://doi.org/10.1021/op049968w
https://doi.org/10.1021/op049968w
Autor:
James C. Peterson, Ajit S. Shah, Gerard A. Dutra, Achilles M. Karakas, Don R. Stano, Shine K. Chou, John R. Springer, Kin-Yin Ng, Levine Jeffrey A, Yinong Ma, Wettach Richard Harold, Patelis Lefteris, Jerry D. Clark, Jerald D. Heise
Publikováno v:
Organic Process Research & Development. 8:176-185
Described are studies directed toward the chemical research and development of an alternative synthesis to 9, the penultimate intermediate of clofencet (1), a novel wheat-hybridizing agent. Retrosynthetic analyses as well as the results obtained from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f77da72ed34311ead8e9bcb4b890b739
https://doi.org/10.1021/op034123q
https://doi.org/10.1021/op034123q