Zobrazeno 1 - 10
of 402
pro vyhledávání: '"Jerry, Pelletier"'
Autor:
Zihao Wang, Ritesh P. Thakare, Shalaka Chitale, Alok K. Mishra, Stanley I. Goldstein, Alice C. Fan, Rui Li, Lihua Julie Zhu, Lauren E. Brown, Regina Cencic, Sidong Huang, Michael R. Green, Jerry Pelletier, Sunil K. Malonia, John A. Porco
Publikováno v:
ACS Central Science, Vol 10, Iss 8, Pp 1640-1656 (2024)
Externí odkaz:
https://doaj.org/article/3b8ffa6689c34fa3a6cde5b04740c305
Autor:
Inci S. Aksoylu, Pauline Martin, Francis Robert, Krzysztof J. Szkop, Nicholas E. Redmond, Srirupa Bhattacharyya, Jennifer Wang, Shan Chen, Roberta L. Beauchamp, Irene Nobeli, Jerry Pelletier, Ola Larsson, Vijaya Ramesh
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disorder caused by mutations in the TSC1 or TSC2 genes, with patients often exhibiting neurodevelopmental (ND) manifestations termed TSC-associated neuropsychiatric d
Externí odkaz:
https://doaj.org/article/057c7629fc914290bfd51a7dc5438070
Autor:
Samer Girgis, Zaikun Xu, Spyros Oikonomopoulos, Alla D. Fedorova, Egor P. Tchesnokov, Calvin J. Gordon, T. Martin Schmeing, Matthias Götte, Nahum Sonenberg, Pavel V. Baranov, Jiannis Ragoussis, Tom C. Hobman, Jerry Pelletier
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Genomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication.
Externí odkaz:
https://doaj.org/article/5e493b54c37c47c3a8ea41d5c87f53e3
Autor:
Leo Shen, Lauren Pugsley, Regina Cencic, HanChen Wang, Francis Robert, Sai Kiran Naineni, Ananya Sahni, Geneviève Morin, Wenhan Zhang, Anastasia Nijnik, John A. Porco, David Langlais, Sidong Huang, Jerry Pelletier
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Rocaglates are a class of eukaryotic translation initiation inhibitors that are being explored as chemotherapeutic agents. They function by targeting eukaryotic initiation factor (eIF) 4A, an RNA helicase critical for recruitment of the 40S
Externí odkaz:
https://doaj.org/article/8c4f9a7786f645b480c54ec87a7139b4
Autor:
Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa Yao, Faith Gorton, Junwei Shi, Craig J. Thomas, Lauren E. Brown, John A. Porco, Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and gl
Externí odkaz:
https://doaj.org/article/5805d19b9df44bceaf4b4ac6e534ad64
Autor:
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability
Externí odkaz:
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66
Autor:
Jerry Pelletier, Nahum Sonenberg
Publikováno v:
Biochemical Society Transactions. 51:113-124
Fundamental studies unraveled the role of eukaryotic initiation factor (eIF) 4E in mRNA translation and its control. Under physiological conditions, regulation of translation by eIF4E is essential to cellular homeostasis. Under stress, gene flow info
Autor:
Mohamed Moustafa-Kamal, Thomas J. Kucharski, Wissal El-Assaad, Yazan M. Abbas, Valentina Gandin, Bhushan Nagar, Jerry Pelletier, Ivan Topisirovic, Jose G. Teodoro
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108230- (2020)
Summary: mTOR is a serine/threonine kinase and a master regulator of cell growth and proliferation. Raptor, a scaffolding protein that recruits substrates to mTOR complex 1 (mTORC1), is known to be phosphorylated during mitosis, but the significance
Externí odkaz:
https://doaj.org/article/56ba8a5170e044c6b5e011acf3998309
Autor:
Jennifer Chu, Wenhan Zhang, Regina Cencic, Patrick B.F. O’Connor, Francis Robert, William G. Devine, Asher Selznick, Thomas Henkel, William C. Merrick, Lauren E. Brown, Pavel V. Baranov, John A. Porco, Jr., Jerry Pelletier
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2481-2488.e5 (2020)
Summary: Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies. As a result, this family of compounds has been significan
Externí odkaz:
https://doaj.org/article/21a67c621b25477f8f89045cf022ad46
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1627-1635 (2018)
Genetically engineered mouse models (GEMMs) are powerful tools by which to probe gene function in vivo, obtain insight into disease etiology, and identify modifiers of drug response. Increased sophistication of GEMMs has led to the design of tissue-s
Externí odkaz:
https://doaj.org/article/56c199e4afd447a19de5356776ec478e