Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jerrod A. Poe"'
Autor:
Rosalba Perrone, Matteo Nadai, Jerrod A Poe, Ilaria Frasson, Manlio Palumbo, Giorgio Palù, Thomas E Smithgall, Sara N Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73121 (2013)
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome. In particular, they have
Externí odkaz:
https://doaj.org/article/24f856fea414412cadb23b059038d14d
The Accessory Factor Nef Links HIV-1 to Tec/Btk Kinases in an Src Homology 3 Domain-dependent Manner
Publikováno v:
Journal of Biological Chemistry. 289:15718-15728
The HIV-1 Nef virulence factor interacts with multiple host cell-signaling proteins. Nef binds to the Src homology 3 domains of Src family kinases, resulting in kinase activation important for viral infectivity, replication, and MHC-I down-regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26af871c861f7ae6e77d7a7280f4c5d
https://doi.org/10.1074/jbc.m114.572099
https://doi.org/10.1074/jbc.m114.572099
Publikováno v:
SLAS Discovery. 19:556-565
Nef is a human immunodeficiency virus 1 (HIV-1) accessory factor essential for viral pathogenesis and AIDS progression. Many Nef functions require dimerization, and small molecules that block Nef dimerization may represent antiretroviral drug leads.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d33fc10fa8938dd8898c81e45ced94
https://doi.org/10.1177/1087057113513640
https://doi.org/10.1177/1087057113513640
Autor:
Haibin Shi, Purushottam Narute, Joanne I. Yeh, Paul A. Johnston, Naveena Yanamala, Lori A. Emert-Sedlak, Sherry T. Shu, Thomas E. Smithgall, Jerrod A. Poe, John Jeff Alvarado, John S. Lazo
Publikováno v:
Chemistry & Biology. 20:82-91
SummaryHIV-1 Nef, a critical AIDS progression factor, represents an important target protein for antiretroviral drug discovery. Because Nef lacks intrinsic enzymatic activity, we developed an assay that couples Nef to the activation of Hck, a Src fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f94dd5481c8874100b7f7e07047b69b
https://doi.org/10.1016/j.chembiol.2012.11.005
https://doi.org/10.1016/j.chembiol.2012.11.005
Autor:
Jerrod A. Poe, Thomas E. Smithgall
Publikováno v:
Journal of Molecular Biology. 394:329-342
Nef, a human immunodeficiency virus type 1 (HIV-1) accessory factor capable of interaction with a diverse array of host cell signaling molecules, is essential for high-titer HIV replication and AIDS progression. Previous biochemical and structural st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c385762ed26564ad25572fbe58097318
https://doi.org/10.1016/j.jmb.2009.09.047
https://doi.org/10.1016/j.jmb.2009.09.047
Autor:
John R. Engen, Thomas E. Wales, Jerrod A. Poe, Christopher R. Morgan, Thomas E. Smithgall, Lori A. Emert-Sedlak
Publikováno v:
Journal of the American Society for Mass Spectrometry. 27(6)
Hydrogen exchange mass spectrometry can be used to compare the conformation and dynamics of proteins that are similar in tertiary structure. If relative deuterium levels are measured, differences in sequence, deuterium forward- and back-exchange, pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4709a8755f2881cae1d9a3e6b87fd5
https://pubmed.ncbi.nlm.nih.gov/27032648
https://pubmed.ncbi.nlm.nih.gov/27032648
Publikováno v:
Biochemistry. 43:15775-15784
Hck is a member of the Src protein-tyrosine kinase family and is expressed strongly in macrophages, an important HIV target cell. Previous studies have shown that Nef, an HIV-1 accessory protein essential for AIDS progression, binds and activates Hck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf189546fa44e80792743f35f1b2ba5
https://doi.org/10.1021/bi048712f
https://doi.org/10.1021/bi048712f
Autor:
Manlio Palumbo, Elena Butovskaya, Giorgio Palù, Ilaria Frasson, Sara N. Richter, Matteo Nadai, Rosalba Perrone, Jerrod A. Poe, Thomas E. Smithgall
G-Quadruplexes, noncanonical nucleic acid structures, act as silencers in the promoter regions of human genes; putative G-quadruplex forming sequences are also present in promoters of other mammals, yeasts, and prokaryotes. Here we show that also the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf78e2142dc076e156926254fabcc5e6
http://hdl.handle.net/11577/2678462
http://hdl.handle.net/11577/2678462
Autor:
Sara N. Richter, Thomas E. Smithgall, Matteo Nadai, Manlio Palumbo, Giorgio Palù, Ilaria Frasson, Jerrod A. Poe, Rosalba Perrone
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e73121 (2013)
Università degli Studi di Padova-IRIS
PLoS ONE, Vol 8, Iss 8, p e73121 (2013)
Università degli Studi di Padova-IRIS
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome. In particular, they have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2172aeb7b102c5dba77df84ee9d2e4f
https://doi.org/10.1371/journal.pone.0073121
https://doi.org/10.1371/journal.pone.0073121