Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

Autor: Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi

Publikováno v: Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)

Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more c

Externí odkaz: https://doaj.org/article/0c66d90901d244e6922dd1f9ea0a3f1f

Randomized phase III study of maintenance selinexor versus placebo in endometrial cancer (ENGOT-EN5/GOG-3055/SIENDO): Impact of subgroup analysis and molecular classification

Autor: Vicky Makker, Jose Alejandro Perez-Fidalgo, Alice Bergamini, Daniel Lewis Spitz, Toon Van Gorp, Jalid Sehouli, Jaroslav Klat, Tamar Perri, Amit M. Oza, Estrid Vilma Solyom Hogdall, Jason A. Konner, Eva M. Guerra, Francesco Raspagliesi, Stephanie Henry, Bradley J. Monk, Jeronimo Martinez Garcia, Brian M. Slomovitz, Sharon Shacham, Mansoor Raza Mirza, Ignace Vergote

Publikováno v: Journal of Clinical Oncology. 40:5511-5511

5511 Background: Endometrial cancers (ECs) are stratified into four molecular categories: wild type TP53 with non-specific molecular profile typically with microsatellite stability (NSMP, p53wt/MSS), DNA polymerase ε exonuclease domain-mutated (POLE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb9715624677112e28b2745716653d39
https://doi.org/10.1200/jco.2022.40.16_suppl.5511

Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial

Autor: Ignace Vergote, Giovanni Scambia, David M O'Malley, Ben Van Calster, Sang-Yoon Park, Josep M del Campo, Werner Meier, Aristotelis Bamias, Nicoletta Colombo, Robert M Wenham, Al Covens, Christian Marth, Mansoor Raza Mirza, Judith R Kroep, Haijun Ma, Cheryl A Pickett, Bradley J Monk, Sang Yoon Park, Yong Sang Song, Yulia Makarova, Joshua Trinidad, Hextan Yuen Sheung Ngan, Gerasimos Aravantinos, Joo-Hyun Nam, Vera Gorbunova, Ludmila Krikunova, Duk-Soo Bae, Jose Angel Arranz Arija, Claudio Zamagni, Christos Papandreou, Francesco Raspagliesi, Alla Lisyanskaya, Ana Oaknin Benzaquen, Germana Tognon, Eugenia Ortega, Antonio Casado Herraez, Joseph Buscema, Andrew Green, Robert Burger, Dina Sakaeva, Andres Redondo Sanchez, Sharad Ghamande, Laurel King, Edgar Petru, Ulla Peen, Satoshi Takeuchi, Kimio Ushijima, Antonio Gonzalez Martin, Scott Kamelle, Michael Carney, Frédéric Forget, James Bentley, Jalid Sehouli, Paolo Zola, Hidenori Kato, Natalya Fadeeva, Evgeny Gotovkin, Vladimir Vladimirov, Margarita Romeo Marin, Eva Guerra Alia, Mark Shahin, Snehalkumar Bhoola, Krishnansu Tewari, Daniel Anderson, Brigitte Honhon, Joseph (Gino) Pelgrims, Amit Oza, Jesus Garcia-Donas Jimenez, Vincent Hansen, David O'Malley, Ivor Benjamin, Vincent Renard, Heidi Van den Bulck, Claudia Haenle, Georgios Koumakis, Harushige Yokota, Vadim Popov, William Bradley, Robert Wenham, Robert Reid, Donna McNamara, Richard Friedman, Joyce Barlin, Nicola Spirtos, Julia Chapman, Paul Sevelda, Manon Huizing, Caroline Lamot, Frédéric Goffin, Lionel D Hondt, Allan Covens, Silvana Spadafora, Beate Rautenberg, Toralf Reimer, Volker Möbus, Felix Hilpert, Martina Gropp-Meier, Antonella Savarese, Sandro Pignata, Francesco Verderame, Mika Mizuno, Hirokuni Takano, Petronella Ottevanger, Andres Poveda Velasco, Isabel Palacio-Vazquez, Amy Law, Kristi McIntyre, Michael Teneriello, Abbie Fields, Samuel Lentz, Daron Street, Benjamin Schwartz, Robert Mannel, Peter Lim, Heather Pulaski, Wolfgang Janni, Andreas Zorr, Ulrich Karck, Ashley Chi Kin Cheng, Roberto Sorio, Cesare Gridelli, Daisuke Aoki, Tetsuro Oishi, Yasuyuki Hirashima, Ingrid Boere, Esther Falco Ferrer, Patricia Braly, Sharon Wilks, Christine Lee, Jeanne Schilder, Dan Veljovich, Angeles Secord, Kevin Davis, Luis Rojas-Espaillat, Shashikant Lele, Stephen DePasquale, Robert Squatrito, Christian Schauer, Luc Dirix, Peter Vuylsteke, Eric Joosens, Diane Provencher, Hans-Joachim Lueck, Alexander Hein, Alexander Burges, Ulrich Canzler, Tjoung-Won Park-Simon, Frank Griesinger, Angiolo Gadducci, Oscar Alabiso, Aikou Okamoto, Takashi Sawasaki, Toshiaki Saito, Ana Herrero Ibañez, Coralia Calomeni, Monique Spillman, Janak Choksi, Nicholas Taylor, Carolyn Muller, David Moore, Paul DiSilvestro, Mary Cunningham, Peter Rose, Peter Oppelt, Didier Verhoeven, Marie-Pascale Graas, Prafull Ghatage, Katia Tonkin, Christian Kurzeder, Benjamin Schnappauf, Volkmar Müller, Hannah Schmalzrie, Haralambos Kalofonos, Milena Bruzzone, Judith Kroep, Cristina Caballero Diaz, Jeronimo Martinez Garcia, Susana Hernando Polo, Mitchell Garrison, Rodney Rocconi, Stephen Andrews, Robert Bristow, Michael McHale, Jack Basil, William Houck III, Maria Bell, Jonathan Cosin, Susan Modesitt, James Kendrick, James Wade III, Cheung Wong, Anthony Evans, Thomas Buekers, Timothy Vanderkwaak, James Ferriss, Christopher Darus, Stacy DAndre, Robert Higgins, Bradley Monk, Jamie Bakkum-Gamez, Leslie DeMars, Linda Van Le, Larry Puls, Shruti Trehan, James LaPolla, Elizabeth Dickson Michelson, Joseph Merchant, Christopher Peterson, Gary Reid, Donald Seago, Susan Zweizig, Walter Gajewski, Amit Panwalkar, Rudolf Leikermoser, Gerhard Bogner, Philip Debruyne, Randal D'hondt, Patrick Berteloot, Joseph Kerger, James Biagi, Vincent Castonguay, Stephen Welch, Aida Muhic, Martin Heubner, Eva-Maria Grischke, Brigitte Rack, Markus Fleisch, Florian Lordick, Dimitrios Pectasides, Wing Ming Ho, Luigi Selvaggi, Flavia Morales Vasquez, William Orlando Brito Villanueva, Alejandro Molina Alavez, Lonneke Kessels, Ana Santaballa Bertran, Cesar Mendiola Fernandez, Miguel Beltran Fabregat, Salvatore Del Prete, John Elkas, Gary Cecchi, Pallavi Kumar, Warner Huh, Mark Messing, Misagh Karimi, Ann Kelley, Babak Edraki, David Mutch, Gary Leiserowitz, Jeanne Anderson, Scott Lentz, Setsuko Chambers, Robert Morris, Steven Waggoner, Alan Gordon, Michael Method, Peter Johnson, Raymond Lord, Janet Drake, Kulumani Sivarajan, Madhu Midathada, Kristen Rice, Troy Wadsworth, James Pavelka, Robert Edwards, David Scott Miller, Patricia Locantore Ford, Jean Hurteau, David Bender, Veronica Schimp, William Creasman, Rachel Lerner, Donald Chamberlain, Angela Kueck, John McDonald, Salman Malad, Bernice Robinson-Bennett, Susan Davidson, Thomas Krivak, Timothy Lestingi, Hector Arango, Paul Berard, Karen Finkelstein, Rakesh Gaur, Carolyn Krasner, Frederick Ueland, Lance Talmage, Seiko Yamada, Gregory Sutton, Ronald Potkul, Monica Prasad-Hayes, Janet Osborne, Paul Celano, James Thigpen, Sudarshan Sharma, Russell Schilder, Jonathan Tammela, Mary Kemeny, Amy Brown, Eric Eisenhauer, James Williams, Kendrith Rowland, Kenneth Nahum, James Burke, Zahid Dar, Nicole Fleming, Randall Gibb, Alfred Guirguis, Thomas Herzog, Veena John, Santhosh Kumar, Aparna Kamat, Mohamad Kassar, Mario Leitao, Lyuba Levine, Luis Mendez, Dhimant Patel, Emily Berry, David Warshal, Judith Wolf, Corrine Zarwan, Yvonne Collins, Gary Spitzer, Brigitte Miller, Mark Einstein

Publikováno v: The Lancet Oncology, 20(6), 862-876. Lancet Publishing Group
The Lancet Oncology, 20(6), 862-876. ELSEVIER SCIENCE INC

BACKGROUND: Angiopoietin 1 and 2 regulate angiogenesis and vascular remodelling by interacting with the tyrosine kinase receptor Tie2, and inhibition of angiogenesis has shown promise in the treatment of ovarian cancer. We aimed to assess whether tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64a9058d15a739010d9bb6ef9e6a7a8
https://hdl.handle.net/1887/122861

Circulating free DNA and circulating tumor cells as new serum biomarkers in advanced ovarian cancer

Autor: Ana Puertes Boix, Edith Rodriguez, Maria Del Rosario Garcia Hernandez, Jeronimo Martinez Garcia, Miguel Marin, Pilar Sanchez-Henarejos, Marta Guirao Maran, Miler Cuellar, Guadalupe Ruiz Merino, Silver Ros, Jose Luis Alonso Romero, Alicia Cano, David Collados, Rosario Salgado, MDolores Jimenez-Lucas, Asuncion Soto

Publikováno v: Journal of Clinical Oncology. 35:5566-5566

5566 Background: Circulating free DNA (cfDNA) and circulating tumor cells (CTC) are new biomarkers for malignant tumors. Its role on ovarian epithelial cancer (OEC) is not yet well stablished. We analyze its role on advanced OEC compared with CA125 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bd8f58c5bf584368ac237ea94d10e6d
https://doi.org/10.1200/jco.2017.35.15_suppl.5566