Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jerome Tuti"'
Autor:
Florence Lefranc, Tine Mahieu, Jean-François Gaussin, Mohamed El Yazidi, Sébastien Sauvage, Jerome Tuti, Janique Dewelle, Tatjana Mijatovic, Robert Kiss, Francis Darro, Fabrice Ribaucour, Eric Van Quaquebeke, Gentiane Simon, Patrick Dumont, Frank Van Vynckt
Publikováno v:
Journal of Medicinal Chemistry. 50:4122-4134
Amonafide (1), a naphthalimide which binds to DNA by intercalation and poisons topoisomerase IIalpha, has demonstrated activity in phase II breast cancer trials, but has failed thus far to enter clinical phase III because of dose-limiting bone marrow
Autor:
Gentiane Simon, Janique Dewelle, Jerome Tuti, Mohamed El Yazidi, Christine Decaestecker, Robert Kiss, Odile Germaine Nacoulma, Frederic Bruyneel, Aurélie André, Francis Darro, Jean Claude Braekman, Pierre Guissou, Eric Van Quaquebeke
Publikováno v:
Journal of medicinal chemistry. 48(3)
Analysis of the methanolic extract of Calotropis procera root barks enabled the identification of a novel cardenolide (2''-oxovoruscharin) to be made. Of the 27 compounds that we hemisynthesized, one (23) exhibited a very interesting profile with res