Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Jerome S Pinkner"'
Autor:
Lisa K McLellan, Michael R McAllaster, Arthur S Kim, Ľubomíra Tóthová, Patrick D Olson, Jerome S Pinkner, Allyssa L Daugherty, Teri N Hreha, James W Janetka, Daved H Fremont, Scott J Hultgren, Herbert W Virgin, David A Hunstad
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009314 (2021)
Type 1 pili have long been considered the major virulence factor enabling colonization of the urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis of pyelonephritis is less well characterized, due to previous limitatio
Externí odkaz:
https://doaj.org/article/7065da0da0334adc82256aacbadafc8d
Autor:
Taylor M. Nye, Zongsen Zou, Chloe L. P. Obernuefemann, Jerome S. Pinkner, Erin Lowry, Kent Kleinschmidt, Karla Bergeron, Aleksandra Klim, Karen W. Dodson, Ana L. Flores-Mireles, Jennifer N. Walker, Daniel Garrett Wong, Alana Desai, Michael G. Caparon, Scott J. Hultgren
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Catheter-associated urinary tract infections (CAUTIs), a common cause of healthcare-associated infections, are caused by a diverse array of pathogens that are increasingly becoming antibiotic resistant. We analyze the microbial occurrences i
Externí odkaz:
https://doaj.org/article/bbcf2d87b3694f7e89d8818948dfec1e
Autor:
Jeffrey P Henderson, Jan R Crowley, Jerome S Pinkner, Jennifer N Walker, Pablo Tsukayama, Walter E Stamm, Thomas M Hooton, Scott J Hultgren
Publikováno v:
PLoS Pathogens, Vol 5, Iss 2, p e1000305 (2009)
Bacterial pathogens are frequently distinguished by the presence of acquired genes associated with iron acquisition. The presence of specific siderophore receptor genes, however, does not reliably predict activity of the complex protein assemblies in
Externí odkaz:
https://doaj.org/article/b4e5851e8f174387961ea3b1c8a29070
Publikováno v:
PLoS Pathogens, Vol 1, Iss 4, p e35 (2005)
The Streptococcus pyogenes NAD-glycohydrolase (SPN) is a toxic enzyme that is introduced into infected host cells by the cytolysin-mediated translocation pathway. However, how S. pyogenes protects itself from the self-toxicity of SPN had been unknown
Externí odkaz:
https://doaj.org/article/bb3f96ab6b7d4d36b36220ada6f5721f
Autor:
Colin J. Worby, Henry L. Schreiber, Timothy J. Straub, Lucas R. van Dijk, Ryan A. Bronson, Benjamin S. Olson, Jerome S. Pinkner, Chloe L. P. Obernuefemann, Vanessa L. Muñoz, Alexandra E. Paharik, Philippe N. Azimzadeh, Bruce J. Walker, Christopher A. Desjardins, Wen-Chi Chou, Karla Bergeron, Sinéad B. Chapman, Aleksandra Klim, Abigail L. Manson, Thomas J. Hannan, Thomas M. Hooton, Andrew L. Kau, H. Henry Lai, Karen W. Dodson, Scott J. Hultgren, Ashlee M. Earl
Publikováno v:
Nature Microbiology. 7:630-639
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a known reservoir for uropathogenic bacteria, the role of the microbiota in rUTI remains uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d5ca8ef67bcf11c4e13ee2d5ffd68f
https://doi.org/10.1038/s41564-022-01107-x
https://doi.org/10.1038/s41564-022-01107-x
Autor:
Kevin O. Tamadonfar, Gisela Di Venanzio, Jerome S. Pinkner, Karen W. Dodson, Vasilios Kalas, Maxwell I. Zimmerman, Jesus Bazan Villicana, Gregory R. Bowman, Mario F. Feldman, Scott J. Hultgren
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Multidrug-resistant Acinetobacter baumannii infections are an urgent clinical problem and can cause difficult-to-treat nosocomial infections. During such infections, like catheter-associated urinary tract infections (CAUTI), A. baumannii rely on adhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4b803630bfc85dac2e68688f455d74
https://doi.org/10.1073/pnas.2212694120
https://doi.org/10.1073/pnas.2212694120
Autor:
Taylor M. Nye, Hasan Tükenmez, Pardeep Singh, Ana L. Flores-Mireles, Chloe L. P. Obernuefemann, Jerome S. Pinkner, Souvik Sarkar, Mari Bonde, Anders E. G. Lindgren, Karen W. Dodson, Jörgen Johansson, Fredrik Almqvist, Michael G. Caparon, Scott J. Hultgren
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The alarming rise of multidrug-resistant Gram-positive bacteria has precipitated a healthcare crisis, necessitating the development of new antimicrobial therapies. Here we describe a new class of antibiotics based on a ring-fused 2-pyridone backbone,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9a61366ca4e9623d2b9e75c6e13bfa
https://doi.org/10.1073/pnas.2210912119
https://doi.org/10.1073/pnas.2210912119
Autor:
Alexandra E. Paharik, Karla Bergeron, Thomas J. Hannan, Timothy J. Straub, Ashlee M. Earl, Scott J. Hultgren, Wen-Chi Chou, Henry L. Schreiber, Andrew L. Kau, Christopher A. Desjardins, Abigail L. Manson, Ryan A. Bronson, Lucas R. van Dijk, Karen W. Dodson, Aleksandra Klim, Sinéad B. Chapman, Vanessa L. Muñoz, Chloe L. P. Obernuefemann, Jerome S. Pinkner, Colin J. Worby, Bruce J. Walker, H. Henry Lai, Benjamin Olson, Thomas M. Hooton
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a known reservoir for uropathogenic bacteria, the role of the microbiota in rUTI remains uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47c2ec320be5191412a9b591cb5e5f7f
https://doi.org/10.1101/2021.11.15.21266268
https://doi.org/10.1101/2021.11.15.21266268
Autor:
Michael R. McAllaster, Ľubomíra Tóthová, Lisa K. McLellan, Herbert W. Virgin, Arthur S. Kim, Allyssa L. Daugherty, Teri N. Hreha, James W. Janetka, David A. Hunstad, Scott J. Hultgren, Daved H. Fremont, Patrick D. Olson, Jerome S. Pinkner
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 1, p e1009314 (2021)
PLoS Pathogens, Vol 17, Iss 1, p e1009314 (2021)
Type 1 pili have long been considered the major virulence factor enabling colonization of the urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis of pyelonephritis is less well characterized, due to previous limitatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80498426643b7b644eacec0b4e805dfc
https://pubmed.ncbi.nlm.nih.gov/33513212
https://pubmed.ncbi.nlm.nih.gov/33513212
Autor:
James W. Janetka, Scott J. Hultgren, Amarendar Reddy Maddirala, Vasilios Kalas, Jerome S. Pinkner, Roger D. Klein
Publikováno v:
Journal of Medicinal Chemistry. 62:467-479
The F9/Yde/Fml pilus, tipped with the FmlH adhesin, has been shown to provide uropathogenic Escherichia coli (UPEC) a fitness advantage in urinary tract infections (UTIs). Here, we used X-ray structure guided design to optimize our previously describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da688e4ea0bd677cbe8eea4549d44c66
https://doi.org/10.1021/acs.jmedchem.8b01561
https://doi.org/10.1021/acs.jmedchem.8b01561