Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Jerome Robert"'
Autor:
Emily B. Button, Wai Hang Cheng, Carlos Barron, Honor Cheung, Asma Bashir, Jennifer Cooper, Jasmine Gill, Sophie Stukas, David C. Baron, Jerome Robert, Elyn M. Rowe, Peter A. Cripton, Cheryl L. Wellington
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-27 (2021)
Abstract Background Glial fibrillary acidic protein (GFAP) has emerged as a promising fluid biomarker for several neurological indications including traumatic brain injury (TBI), a leading cause of death and disability worldwide. In humans, serum or
Externí odkaz:
https://doaj.org/article/f34d341eb55745efa6c3823f103e6a93
Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 11, Pp 2132-2140 (2021)
The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and oxygen. This supply is coordinated by the action of neurons, glial and vascular cells, known collectively
Externí odkaz:
https://doaj.org/article/5a97d92f8c7a44349afd0b9ba2344af8
Autor:
Jerome Robert, Nicholas L. Weilinger, Li-Ping Cao, Stefano Cataldi, Emily B. Button, Sophie Stukas, Emma M. Martin, Philip Seibler, Megan Gilmour, Tara M. Caffrey, Elyn M. Rowe, Jianjia Fan, Brian MacVicar, Matthew J. Farrer, Cheryl L. Wellington
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract Introduction The neurovascular unit (NVU) – the interaction between the neurons and the cerebrovasculature – is increasingly important to interrogate through human-based experimental models. Although advanced models of cerebral capillari
Externí odkaz:
https://doaj.org/article/bf6b04e51e7642eaa8ed05bcd04de018
Autor:
Wenchen Zhao, Jianjia Fan, Iva Kulic, Cheryl Koh, Amanda Clark, Johan Meuller, Ola Engkvist, Samantha Barichievy, Carina Raynoschek, Ryan Hicks, Marcello Maresca, Qi Wang, Dean G. Brown, Alvin Lok, Cameron Parro, Jerome Robert, Hsien-Ya Chou, Andrea M. Zuhl, Michael W. Wood, Nicholas J. Brandon, Cheryl L. Wellington
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Alzheimer’s disease (AD), the leading cause of dementia, is a chronic neurodegenerative disease. Apolipoprotein E (apoE), which carries lipids in the brain in the form of lipoproteins, plays an undisputed role in AD pathophysiology. A high
Externí odkaz:
https://doaj.org/article/e4c460b7e23b4bd794764f22ba342110
Autor:
Jerome Robert, Emily B. Button, Emma M. Martin, Luke McAlary, Zoe Gidden, Megan Gilmour, Guilaine Boyce, Tara M. Caffrey, Andrew Agbay, Amanda Clark, Judith M. Silverman, Neil R. Cashman, Cheryl L. Wellington
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-21 (2020)
Abstract Background Several lines of evidence suggest that high-density lipoprotein (HDL) reduces Alzheimer’s disease (AD) risk by decreasing vascular beta-amyloid (Aβ) deposition and inflammation, however, the mechanisms by which HDL improve cere
Externí odkaz:
https://doaj.org/article/3a3b31f2c31440f194db508534961efc
Autor:
Sofia Kakava, Eveline Schlumpf, Grigorios Panteloglou, Flavia Tellenbach, Arnold von Eckardstein, Jerome Robert
Publikováno v:
Cells, Vol 11, Iss 19, p 3044 (2022)
The transport of low-density lipoprotein (LDL) through the endothelium is a key step in the development of atherosclerosis, but it is notorious that phenotypic differences exist between endothelial cells originating from different vascular beds. Endo
Externí odkaz:
https://doaj.org/article/c4074ed0ff144e98904b5ba0b39a6fb7
Autor:
Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Sophie Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, Jerome Robert, Kris M. Martens, Cheryl L. Wellington
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Background Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cerebral vessels known
Externí odkaz:
https://doaj.org/article/fb2a691f58d94abb8998aa69e3f67f4a
Autor:
Jianjia Fan, Rui Qi Zhao, Cameron Parro, Wenchen Zhao, Hsien-Ya Chou, Jerome Robert, Tarek Z. Deeb, Carina Raynoschek, Samantha Barichievy, Ola Engkvist, Marcello Maresca, Ryan Hicks, Johan Meuller, Stephen J. Moss, Nicholas J. Brandon, Michael W. Wood, Iva Kulic, Cheryl L. Wellington
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 5, Pp 830-842 (2018)
apoE is the primary lipid carrier within the CNS and the strongest genetic risk factor for late onset Alzheimer's disease (AD). apoE is primarily lipidated via ABCA1, and both are under transcriptional regulation by the nuclear liver X receptor (LXR)
Externí odkaz:
https://doaj.org/article/07292a8383824ead85d89855673a9620
Autor:
Jerome Robert, Emily B Button, Brian Yuen, Megan Gilmour, Kevin Kang, Arvin Bahrabadi, Sophie Stukas, Wenchen Zhao, Iva Kulic, Cheryl L Wellington
Publikováno v:
eLife, Vol 6 (2017)
Amyloid plaques, consisting of deposited beta-amyloid (Aβ), are a neuropathological hallmark of Alzheimer’s Disease (AD). Cerebral vessels play a major role in AD, as Aβ is cleared from the brain by pathways involving the cerebrovasculature, most
Externí odkaz:
https://doaj.org/article/6f64e29cfa0e4806b1dc89e035f6a6ae
Autor:
Shama D. Ahuja, David Ashkin, Monika Avendano, Rita Banerjee, Melissa Bauer, Jamie N. Bayona, Mercedes C. Becerra, Andrea Benedetti, Marcos Burgos, Rosella Centis, Eward D. Chan, Chen-Yuan Chiang, Helen Cox, Lia D'Ambrosio, Kathy DeRiemer, Nguyen Huy Dung, Donald Enarson, Dennis Falzon, Katherine Flanagan, Jennifer Flood, Maria L. Garcia-Garcia, Neel Gandhi, Reuben M. Granich, Maria G. Hollm-Delgado, Timothy H. Holtz, Michael D. Iseman, Leah G. Jarlsberg, Salmaan Keshavjee, Hye-Ryoun Kim, Won-Jung Koh, Joey Lancaster, Christophe Lange, Wiel C. M. de Lange, Vaira Leimane, Chi Chiu Leung, Jiehui Li, Dick Menzies, Giovanni B. Migliori, Sergey P. Mishustin, Carole D. Mitnick, Masa Narita, Philly O'Riordan, Madhukar Pai, Domingo Palmero, Seung-kyu Park, Geoffrey Pasvol, Jose Peña, Carlos Pérez-Guzmán, Maria I. D. Quelapio, Alfredo Ponce-de-Leon, Vija Riekstina, Jerome Robert, Sarah Royce, H. Simon Schaaf, Kwonjune J. Seung, Lena Shah, Tae Sun Shim, Sonya S. Shin, Yuji Shiraishi, José Sifuentes-Osornio, Giovanni Sotgiu, Matthew J. Strand, Payam Tabarsi, Thelma E. Tupasi, Robert van Altena, Martie Van der Walt, Tjip S. Van der Werf, Mario H. Vargas, Pirett Viiklepp, Janice Westenhouse, Wing Wai Yew, Jae-Joon Yim
Publikováno v:
PLoS Medicine, Vol 9, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/d3e1f4810bee4bd79e3093e09aec3563