Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jerome R. Bagley"'
Publikováno v:
Psychopharmacology. 137:67-73
Mirfentanil is a fentanyl derivative with non-opioid actions, including non-opioid antinociceptive effects in rhesus monkeys. The current study examined the rate-altering effects of mirfentanil and several other compounds in pigeons to assess: 1) the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a2164be00a50efdea8acd1595c4695
https://doi.org/10.1007/s002130050594
https://doi.org/10.1007/s002130050594
Publikováno v:
Drug Development Research. 35:49-58
OHM3597, a fentanyl-like piperidine with a thalidomide-like moiety, was studied in rhesus monkeys for its behavioral effects and for its effects on lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)-α, OHM3597 had morphine-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980b8f70a465cdaf34f2417b32d6d5d7
https://doi.org/10.1002/ddr.430350108
https://doi.org/10.1002/ddr.430350108
Autor:
Daniel J.J. Carr, Marc L. Baker, Charles Holmes, Linda L. Brockunier, Jerome R. Bagley, Charles P. France
Publikováno v:
International Journal of Immunopharmacology. 16:835-844
The immunoregulatory effects of fentanyl and a fentanyl-related compound, OHM3295, were studied in mice. Male CD1 mice treated with a range of fentanyl doses (0.1–1.0 mg/kg, subcutaneously) showed suppression of splenic natural killer (NK) activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df4d2b96ea24a9daf216736bcb68b89
https://doi.org/10.1016/0192-0561(94)90057-4
https://doi.org/10.1016/0192-0561(94)90057-4
Autor:
Jerome R. Bagley, Jeffrey A. Wilhelm
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:945-950
The synthesis of [14C]-fentanyl, the radiolabelled congener of the potent opioid analgesic chosen for utilization in drug disposition studies, is described. [14C]-Labelling was achieved in the first of two steps, a room temperature reduction of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ca94b8ad479f67b72aee024acb3b53
https://doi.org/10.1002/jlcr.2580311113
https://doi.org/10.1002/jlcr.2580311113
Publikováno v:
Drug Development Research. 22:189-195
Structural changes to the fentanyl molecule based on heterocyclic modifications at the sector distal to the piperidine nitrogen results in morphine reversal activity. A series of such compounds known as 4-(heteroanilido) piperidines were tested for r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a60f6ed1f7632be45122c8018b76dcf0
https://doi.org/10.1002/ddr.430220209
https://doi.org/10.1002/ddr.430220209
Publikováno v:
Immunopharmacology. 34(1)
Mirfentanil [N-(2-pyrazinyl)-N-(1-phenethyl-4-piperidinyl)-2-furamide] was studied for its antinociceptive and immunomodulatory effects in mice Mirfentanil (1.0-32.0 mg/kg) increased tail-flick latency to a thermal stimulus and this effect was antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df9c22dd0e2e03dd0c10ad67ff2ffff
https://pubmed.ncbi.nlm.nih.gov/8880221
https://pubmed.ncbi.nlm.nih.gov/8880221
Autor:
Mark J. Benvenga, Richard L Wynn, John A. Colapret, Michael H. Ossipov, Theodore C. Spaulding, Nhora Lucia Lalinde, Frieda G. Rudo, Jerome R. Bagley, Bao-Shang Huang, Bor-Sheng Lin, Thomas P. Jerussi, Linas V. Kudzma, Brian M. Doorley, Spencer H Kenneth
Publikováno v:
Medicinal research reviews. 11(4)
The findings reviewed herein have been the results of a five-year project undertaken by Anaquest to discover new therapeutically superior analgesics. The need to provide an analgesic for severe to moderate pain in the perioperative and nonsurgical en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df53c38c2f926282b72a17017699d966
https://pubmed.ncbi.nlm.nih.gov/1875771
https://pubmed.ncbi.nlm.nih.gov/1875771
Publikováno v:
Journal of Chromatographic Science. 18:153-158
A method for the prediction of the retention index of drugs on C18 reversed-phase columns was developed and then applied to a series of drugs that were structurally related to morphine and to a series related to fentanyl. The HPLC retention index (/)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e2936914921d532ca367a48eecd576
https://doi.org/10.1093/chromsci/18.4.153
https://doi.org/10.1093/chromsci/18.4.153
Autor:
Thomas N. Riley, Jerome R. Bagley
Publikováno v:
Journal of Heterocyclic Chemistry. 14:599-602
The isomeric 3-anilino and 3-propananilidotropanes have been synthesized and obtained in isomerically pure form. The configurations and solute conformations of these isomers were studied via glc and nrar analysis. The 3β-isomers have been shown to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::597c70ed8892ea6a1db91b453b41629c
https://doi.org/10.1002/jhet.5570140412
https://doi.org/10.1002/jhet.5570140412
Publikováno v:
Biochemical Pharmacology. 32:2941-2947
Incubation of the nonsteroidal antiestrogen clomiphene with rat liver microsomes resulted in the formation of the 4-hydroxy-, N-desethyl-, and N-oxide metabolites, in qualitative contrast to results previously obtained analogously with rabbit microso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3749649558fbc4ccd2efac958a3f4f6
https://doi.org/10.1016/0006-2952(83)90400-8
https://doi.org/10.1016/0006-2952(83)90400-8