Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Jerome P. Horwitz"'
Autor:
Stuart T. Hazeldine, Jerome P. Horwitz, Lisa Polin, Thomas H. Corbett, Juiwanna Kushner, Kathryn White
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:2462-2467
Conformational restriction of bioactive molecules offers the possibility of generating structures of increased potency. To this end, a synthesis has been achieved of ( R , S )-2-[(8-chlorobenzofurano[2,3- b ]quinolinyl)oxy]propionic acid ( 12a ), a h
Autor:
Lisa Polin, Jerome P. Horwitz, Juiwanna Kushner, Stuart T. Hazeldine, Thomas H. Corbett, Kathryn White
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:3910-3920
The criteria for the activity of 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid (SH80) against transplanted tumors in mice established in previous studies, require a (7-hal
Autor:
Juiwanna Kushner, Chiab Simpson, Matthew Edelstein, Thomas H. Corbett, Susan Pugh, Jennifer Paluch, Jerome P. Horwitz, Lisa Polin, Kathryn White, Stuart T. Hazeldine, Joseph A. Fontana, Patricia LoRusso
Publikováno v:
Investigational New Drugs. 20:13-22
XK-469 is advancing to Phase I clinical trials. Preclinical studies were carried out to assist in clinical applications. DOSE-SCHEDULE ROUTE TESTING: Single dose i.v. treatment with XK-469 produced lethality (LD20 to LD100) above 142 mg/kg. Optimum t
Autor:
Srinivasu Poondru, Vivek Purohit, Bhaskara R. Jasti, Jerome P. Horwitz, Ralph E. Parchment, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin, Patricia LoRusso
Publikováno v:
Investigational New Drugs. 20:23-33
In solid tumors, the reasons for the lack of in vitro and in vivo correlation of drug activities are multifold and includes permeability to the tumor cells, interstitial hypertension and metabolic degradation. So, it is important to study the permeab
Autor:
Jerome P. Horwitz, David Kessel
Publikováno v:
Cancer Letters. 168:141-144
XK469 (2-[4-(7-chloro-2-quinoxalinyloxy) phenoxy]propionic acid) is a new anti-tumor agent with substantial activity against several drug-resistant cell lines. Using murine leukemia L1210 cells in culture, we found the chiral R(+) form of XK469 to be
Autor:
Richard Wiegand, Laurence H. Baker, Thomas H. Corbett, Jerome P. Horwitz, Brenda J. Foster, Eduardo Palomino, Maya B. Kempff
Publikováno v:
Cancer Chemotherapy and Pharmacology. 38:453-458
Purpose. Pyrazoloacridine (PZA) is a newly developed anticancer agent currently undergoing clinical trials. Its mode of action has not been elucidated but the presence in its chemical structure of a 5-nitro functional group and its activity against o
Publikováno v:
Journal of Medicinal Chemistry. 37:781-786
The present study establishes correlations of in vivo growth inhibition of a solid tumor, pancreatic ductal adenocarcinoma (Panc03), of mice with the steric and electrostatic fields and the hydrophobic parameter log P of a series (32) of 1-[[2-(dialk
Autor:
Antoinette J. Wozniak, Thomas H. Corbett, Irina Massova, Judith Sebolt-Leopold, David B. Capps, Thomas E. Wiese, Wilbur R. Leopold, Jerome P. Horwitz
Publikováno v:
Journal of Medicinal Chemistry. 36:3511-3516
In vitro screening of a number of 2-(aminoalkyl)-5-nitropyrazolo[3,4,5- kl]acridines has previously indicated (Sebolt, J.S.; et al. Cancer Res. 1987, 47, 4299-4304) that these compounds, in general, exhibit selective cytotoxicity against the human co
Autor:
Moore Richard E, Alfred J. Lawson, Lisa Polin, Wilbur R. Leopold, Bill J. Roberts, Stuart T. Hazeldine, Jerome P. Horwitz, Juiwanna Kushner, Thomas H. Corbett, James B. Rake, Kathryn White
Publikováno v:
Tumor Models in Cancer Research ISBN: 9781607619673
As preclinical chemotherapists, we are often asked to identify experimental tumor models that can accurately predict for the drug response characteristics of all tumors of a given cellular subtype or molecular target. Unfortunately, it is impossible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1545a271a635685d78dbe5bf4e50efd5
https://doi.org/10.1007/978-1-60761-968-0_3
https://doi.org/10.1007/978-1-60761-968-0_3
Publikováno v:
Nucleosides and Nucleotides. 11:1639-1649
The present study extends the dihdropyridine ⇌ pyridinium salt redox system to the delivery and sustained release of 2′,3′-dideoxycytidine (DDC) to the brains of mice in a continuing search for agents that may prove effective in reversing compl