Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jerome P, Trzeciakowski"'
Autor:
Paola C. Rosas, MD, PhD, BSPharm, Chad M. Warren, MS, Heidi A. Creed, BS, Jerome P. Trzeciakowski, PhD, R. John Solaro, PhD, Carl W. Tong, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 817-830 (2019)
Summary: Cardiac myosin binding protein-C (cMyBP-C) phosphorylation prevents aging-related cardiac dysfunction. We tested this hypothesis by aging genetic mouse models of hypophosphorylated cMyBP-C, wild-type equivalent, and phosphorylated-mimetic cM
Externí odkaz:
https://doaj.org/article/3f0f466b8a174049852691b9fb177b8e
Autor:
Xiaona Li, Qin Ni, Xiuxiu He, Jun Kong, Soon-Mi Lim, Garegin A Papoian, Jerome P Trzeciakowski, Andreea Trache, Yi Jiang
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007693 (2020)
Understanding cellular remodeling in response to mechanical stimuli is a critical step in elucidating mechanical activation of biochemical signaling pathways. Experimental evidence indicates that external stress-induced subcellular adaptation is acco
Externí odkaz:
https://doaj.org/article/925214784ef44ba496c305d032eba865
Autor:
John W. Seawright, Harini Sreenivasappa, Holly C. Gibbs, Samuel Padgham, Song Y. Shin, Christine Chaponnier, Alvin T. Yeh, Jerome P. Trzeciakowski, Christopher R. Woodman, Andreea Trache
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Aging induces a progressive decline in vasoconstrictor responses in central and peripheral arteries. This study investigated the hypothesis that vascular smooth muscle (VSM) contractile function declines with age in soleus muscle feed arteries (SFA).
Externí odkaz:
https://doaj.org/article/99e70e9dbc494fe4b0d756a1750f091c
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199029 (2018)
The current study examined micro RNA (miRNAs) clusters from the maternal plasma to determine their association with preterm birth (PTB) and infant birth outcomes. A subsample of 42 participants who spontaneously delivered either preterm (≤37 weeks)
Externí odkaz:
https://doaj.org/article/dd2db93836b64472b9ba3b59b793074e
Ventricular remodeling is one of the primary adaptive mechanisms in response to long-term mechanical overload in diabetes. In addition to cardiomyocyte hypertrophy, alterations in noncardiomyocyte compartments [e.g. extracellular matrix (ECM)] are an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa97270b5ae5eb549b92adb0edef74d3
https://doi.org/10.1101/2022.11.15.516690
https://doi.org/10.1101/2022.11.15.516690
Autor:
Tracey L Weissgerber, Vesna D Garovic, Jelena S Milin-Lazovic, Stacey J Winham, Zoran Obradovic, Jerome P Trzeciakowski, Natasa M Milic
Publikováno v:
PLoS Biology, Vol 14, Iss 4, p e1002430 (2016)
Numerous studies demonstrating that statistical errors are common in basic science publications have led to calls to improve statistical training for basic scientists. In this article, we sought to evaluate statistical requirements for PhD training a
Externí odkaz:
https://doaj.org/article/477383a270024e9ab00fc0a09069cffa
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162501 (2016)
Borrelia burgdorferi is a spirochetal bacterium transmitted by the Ixodes tick that causes Lyme disease in humans due to its ability to evade the host immune response and disseminate to multiple immunoprotective tissues. The pathogen undergoes dynami
Externí odkaz:
https://doaj.org/article/714d758d84684d699067cab506a3cb21
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Lyme disease, caused by Borrelia burgdorferi, is an inflammatory multistage infection, consisting of localized, disseminated, and persistent disease stages, impacting several organ systems through poorly defined gene regulation mechanisms. The purpos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1423e36b5de7c6786b45b020f38547
http://link.springer.com/article/10.1038/s41598-020-69212-7
http://link.springer.com/article/10.1038/s41598-020-69212-7
Autor:
Jerome P. Trzeciakowski, R. John Solaro, Paola C Rosas, Heidi A. Creed, Chad M. Warren, Carl W. Tong
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 817-830 (2019)
JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 817-830 (2019)
Visual Abstract
Highlights • With aging, phosphorylated-mimetic cMyBP-C mice exhibited better survival, better preservation of systolic and diastolic functions, and unchanging wall thickness compared with control mice. • Aged wild-type equiv
Highlights • With aging, phosphorylated-mimetic cMyBP-C mice exhibited better survival, better preservation of systolic and diastolic functions, and unchanging wall thickness compared with control mice. • Aged wild-type equiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762be68ac3a40691e31022888af60083
http://europepmc.org/articles/PMC6978553
http://europepmc.org/articles/PMC6978553
Autor:
Garegin A. Papoian, Xiuxiu He, Soon-Mi Lim, Li X, Jun Kong, Qin Ni, Jerome P. Trzeciakowski, Yi Jiang, Andreea Trache
Understanding cellular remodeling in response to mechanical stimuli is a critical step in elucidating mechano-activation of biochemical signaling pathways. Experimental evidence indicates that external stress-induced subcellular adaptation is accompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e1e7731e654dc3b7702c1fda34ee97
https://doi.org/10.1101/2020.02.03.932863
https://doi.org/10.1101/2020.02.03.932863