Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jerome N Feige"'
Autor:
Elie Antoun, Eugenia Migliavacca, Emma S Garratt, Sheila J Barton, Phil Titcombe, Leo D Westbury, Alica Baczynska, Richards Dodds, Helen C Roberts, Avan A Sayer, Sarah Shaw, H.E. Syddall, Allan Sheppard, Craig McFarlane, Neerja Karnani, Terrence Forrester, Cyrus Cooper, Jerome N Feige, Harnish P Patel, Keith M Godfrey, Karen A Lillycrop, the EpiGen Global Research Consortium
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 2, Pp 207-221 (2021)
Abstract Background Despite increasing knowledge of the pathogenesis of muscle ageing, the molecular mechanisms are poorly understood. Based on an expression analysis of muscle biopsies from older Caucasian men, we undertook an in‐depth analysis of
Externí odkaz:
https://doaj.org/article/a5b9c209ed974c5ab4dd714c72918127
Autor:
Omid Mashinchian, Xiaotong Hong, Joris Michaud, Eugenia Migliavacca, Gregory Lefebvre, Christophe Boss, Filippo De Franceschi, Emmeran Le Moal, Jasmin Collerette-Tremblay, Joan Isern, Sylviane Metairon, Frederic Raymond, Patrick Descombes, Nicolas Bouche, Pura Muñoz-Cánoves, Jerome N Feige, C Florian Bentzinger
Publikováno v:
eLife, Vol 11 (2022)
Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on s
Externí odkaz:
https://doaj.org/article/e06534e7b8fc4105bcfcb17a74fd6563
Autor:
Laurent Perrin, Ursula Loizides-Mangold, Stéphanie Chanon, Cédric Gobet, Nicolas Hulo, Laura Isenegger, Benjamin D Weger, Eugenia Migliavacca, Aline Charpagne, James A Betts, Jean-Philippe Walhin, Iain Templeman, Keith Stokes, Dylan Thompson, Kostas Tsintzas, Maud Robert, Cedric Howald, Howard Riezman, Jerome N Feige, Leonidas G Karagounis, Jonathan D Johnston, Emmanouil T Dermitzakis, Frédéric Gachon, Etienne Lefai, Charna Dibner
Publikováno v:
eLife, Vol 7 (2018)
Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchro
Externí odkaz:
https://doaj.org/article/8ea7e67b24d542c897c0de2adf446cbc
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71084 (2013)
The marbling of skeletal muscle by ectopic adipose tissue is a hallmark of many muscle diseases, including sarcopenia and muscular dystrophies, and generally associates with impaired muscle regeneration. Although the etiology and the molecular mechan
Externí odkaz:
https://doaj.org/article/85ad91dcc360437aba9196f424b25dbf
Autor:
Mary C. Stephenson, Jamie X.M. Ho, Eugenia Migliavacca, Maria Kalimeri, Neerja Karnani, Subhasis Banerji, John J. Totman, Jerome N. Feige, Reshma A. Merchant, Stacey K.H. Tay
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1482-1494 (2023)
Abstract Background Mitochondrial dysfunction has been implicated in sarcopenia. 31P magnetic resonance spectroscopy (MRS) enables non‐invasive measurement of adenosine triphosphate (ATP) synthesis rates to probe mitochondrial function. Here, we as
Externí odkaz:
https://doaj.org/article/db4a386da10847ff80503a8a94989940
Autor:
Anna Weiser, Aurélie Hermant, Flavien Bermont, Federico Sizzano, Sonia Karaz, Pilar Alvarez-Illera, Jaime Santo-Domingo, Vincenzo Sorrentino, Jerome N. Feige, Umberto De Marchi
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102759- (2023)
Regulation of mitochondrial redox balance is emerging as a key event for cell signaling in both physiological and pathological conditions. However, the link between the mitochondrial redox state and the modulation of these conditions remains poorly d
Externí odkaz:
https://doaj.org/article/a579efc55ff94776a164adcc0e5fb71f
Autor:
Umji Lee, Pascal Stuelsatz, Sonia Karaz, David W. McKellar, Julie Russeil, Maria Deak, Iwijn De Vlaminck, Christoph Lepper, Bart Deplancke, Benjamin D. Cosgrove, Jerome N. Feige
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104589- (2022)
Summary: Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and metabolism and declines during aging. Through a yeast one-hybrid transcription factor binding screen, we identified the TEA domain transcription factor 1 (Tead1) as a n
Externí odkaz:
https://doaj.org/article/5b78ad39c82e4e3080f88739f302cb31
Autor:
Gaia Gherardi, Anna Weiser, Flavien Bermont, Eugenia Migliavacca, Benjamin Brinon, Guillaume E. Jacot, Aurélie Hermant, Mattia Sturlese, Leonardo Nogara, Denis Barron, Stefano Moro, Bert Blaauw, Rosario Rizzuto, Jerome N. Feige, Cristina Mammucari, Umberto De Marchi
SUMMARYMitochondrial calcium (mtCa2+) uptake via the Mitochondrial Calcium Uniporter (MCU) couples the regulation of calcium homeostasis to energy production. mtCa2+uptake is rate-limiting for mitochondrial activation during muscle contraction, but h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a196ae356497202c5b69aa3aac44bdb
https://doi.org/10.1101/2023.02.24.529830
https://doi.org/10.1101/2023.02.24.529830
Autor:
Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier, Joël Boutin, Junio Dort, Zakaria Orfi, Joris Michaud, Hugo Giguère, Alexandre Desroches, Kien Trân, François Vézina, Sonia Bedard, Catherine Raynaud, Frederic Balg, Philippe Sarret, Michelle S. Scott, Jerome N. Feige, Jean-Bernard Denault, Nicolas A. Dumont, Eric Marsault, Mannix Auger-Messier, C. Florian Bentzinger
Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here we describe that defects in the endothelial cell (EC) compartment of the perivascular stem cell niche in thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ef9e1393dd6bc0f84458d9e32277c0
https://doi.org/10.1101/2022.09.09.507274
https://doi.org/10.1101/2022.09.09.507274
Publikováno v:
Trends in Cell Biology. 31:556-568
Muscle stem cells (MuSCs) are tissue-resident stem cells required for growth and repair of skeletal muscle, that are otherwise maintained in a cell-cycle-arrested state called quiescence. While quiescence was originally believed to be a state of cell