Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jerome Mertens"'
Autor:
Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens, Lino Ferreira
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or
Externí odkaz:
https://doaj.org/article/d33c757272e7466e9b010a7adbc884c6
Autor:
Mark van den Hurk, Shong Lau, Maria C. Marchetto, Jerome Mertens, Shani Stern, Olga Corti, Alexis Brice, Beate Winner, Jürgen Winkler, Fred H. Gage, Cedric Bardy
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia nigra neurons in Parkinson’s disease (PD). Deciphering the human molecular makeup of PD pathophysiology can guide the discovery of therapeutics to s
Externí odkaz:
https://doaj.org/article/14683e153a4e4a20901fa0656fbb2213
Autor:
Cristina Marisol Castillo Bautista, Kristin Eismann, Marc Gentzel, Silvia Pelucchi, Jerome Mertens, Hannah E. Walters, Maximina H. Yun, Jared Sterneckert
Publikováno v:
Cells, Vol 12, Iss 18, p 2247 (2023)
Aging is associated with the disruption of protein homeostasis and causally contributes to multiple diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring protein homeostasis and protecting neurons against age-dependent d
Externí odkaz:
https://doaj.org/article/fa8aa0500c5d451eb80a3e477c6cd4bd
Autor:
Larissa Traxler, Jessica Lagerwall, Sophie Eichhorner, Davide Stefanoni, Angelo D'Alessandro, Jerome Mertens
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
An uninterrupted energy supply is critical for the optimal functioning of all our organs, and in this regard the human brain is particularly energy dependent. The study of energy metabolic pathways is a major focus within neuroscience research, which
Externí odkaz:
https://doaj.org/article/36167fda9b67405caaff154a65d8e67e
Autor:
Yongsung Kim, Xinde Zheng, Zoya Ansari, Mark C. Bunnell, Joseph R. Herdy, Larissa Traxler, Hyungjun Lee, Apua C.M. Paquola, Chrysanthi Blithikioti, Manching Ku, Johannes C.M. Schlachetzki, Jürgen Winkler, Frank Edenhofer, Christopher K. Glass, Andres A. Paucar, Baptiste N. Jaeger, Son Pham, Leah Boyer, Benjamin C. Campbell, Tony Hunter, Jerome Mertens, Fred H. Gage
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2550-2558 (2018)
Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields fu
Externí odkaz:
https://doaj.org/article/745b25dfd2684290864d22273782c442
Autor:
Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda
Publikováno v:
Cells, Vol 10, Iss 8, p 1894 (2021)
Neuronal culture was used to investigate neuronal function in physiological and pathological conditions. Despite its inevitability, primary neuronal culture remained a gold standard method that requires laborious preparation, intensive training, and
Externí odkaz:
https://doaj.org/article/a259c185523a443386c5f3071be2580b
Autor:
Joseph Herdy, Simon Schafer, Yongsung Kim, Zoya Ansari, Dina Zangwill, Manching Ku, Apua Paquola, Hyungjun Lee, Jerome Mertens, Fred H Gage
Publikováno v:
eLife, Vol 8 (2019)
Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages. Although iN technology has an enormous potential for modeling age-related dis
Externí odkaz:
https://doaj.org/article/3e403c8aedd14108b8fe7d58a335b439
Autor:
Xinde Zheng, Leah Boyer, Mingji Jin, Jerome Mertens, Yongsung Kim, Li Ma, Michael Hamm, Fred H Gage, Tony Hunter
Publikováno v:
eLife, Vol 5 (2016)
How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the tr
Externí odkaz:
https://doaj.org/article/221dfd8b30b24e6cb42a4ace07578e2c
Autor:
Alerie G. de la Fuente, Silvia Pelucchi, Jerome Mertens, Monica Di Luca, Daniela Mauceri, Elena Marcello
Publikováno v:
British Journal of Pharmacology.
Ageing is the main risk factor common to most primary neurodegenerative disorders. Indeed, age-related brain alterations have been long considered to predispose to neurodegeneration. Although protein misfolding and the accumulation of toxic protein a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f06a9cb8a3eee2a44e21ea04f8cdbd4
https://doi.org/10.1111/bph.16078
https://doi.org/10.1111/bph.16078
Autor:
Frank Edenhofer, Angeliki Spathopoulou, Gabriella Fenkart, Valentin Marteau, Martina Podlesnic, Katharina Kruszewski, Marja Koskuvi, János Réthelyi, Ágota Apáti, Luciano Conti, Manching Ku, Therese Koal, Udo Müller, Radu Talmazan, Ilkka Ojansuu, Olli Vaurio, Markku Lähteenvuo, Šárka Lehtonen, Jerome Mertens, Katharina Günther, Jari Tiihonen, Jari Koistinaho, Zlatko Trajanoski
Schizophrenia is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. Recently, metabolomic studies based on patients’ biofluids and post-mortem brain specimens have revealed altered levels of distinct metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::708880bae100ce86a59ab0ccdced3931
https://doi.org/10.21203/rs.3.rs-2175912/v1
https://doi.org/10.21203/rs.3.rs-2175912/v1
