Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jerome Menegotto"'
Autor:
Philippe Péron, Marie-Aude Chabanaud, Gwladys Langot, Etienne Guillot, Florence Goumy, Patrick Mougenot, Cecile Pascal, Olivier Crespin, Fabrice Viviani, Majdi Ben-Hassine, Friedemann Schmidt, Eykmar Fett, Jean-Christophe Le Bail, Jean-Luc Ragot, Bénédicte Onofri, Rommel Dadji-Faïhun, Christophe Philippo, Thao Van-Pham, Catherine Monseau, Olivier Venier, Jerome Menegotto, Florence Chatelain-Egger, Marie-Pierre Pruniaux, François Pacquet, Philippe Chamiot-Clerc, Eric Nicolai, Claudie Namane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:25-32
Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccd83610869fd9f5432e155ed4fbc2f
https://doi.org/10.1016/j.bmcl.2015.11.046
https://doi.org/10.1016/j.bmcl.2015.11.046
Autor:
Stephanie Versluys, Pierre Fons, Michael R. Paillasse, Celia bergeaud, Federica Ferigo, Andrew Simon Bell, Richard Cox, Jérémy Besnard, Eric Cogo, Simone Culurgioni, Sean Robinson, Frederic Machet, Sabrina Pagliarusco, Emilie Pelissier, Craig Johnstone, Iva Hopkins-Navratilova, Jerome Menegotto, Emilie Mirey, Michael Esquerre, Joanna Lisztwan, Florie Bertrand, Virgile Visentin, Celine Poussereau-Pomie, Andrew Payne, Adrian Schreyer, Andrew L. Hopkins, Mark Whittaker
Publikováno v:
Cancer Research. 79:519-519
Evotec and Exscientia are collaborating to develop an innovative drug discovery platform for accelerating small molecule development in Immuno-Oncology. The primary focus is to target the immunosuppressive adenosine pathway. We have firstly sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01d93767d9b8f4fca64cf05cb71ac2ed
https://doi.org/10.1158/1538-7445.am2019-519
https://doi.org/10.1158/1538-7445.am2019-519
Autor:
Jerome Menegotto, Cédric Couturier, Anna M. Upton, Christine Lair, Eric Bacqué, Sophie Lagrange, Armin Bauer, Takushi Kaneko, Bodo Scheiper, Eric Cogo, Corinne Perron, Alain Pellet
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(21)
A high throughput phenotypic screening against Mycobacterium smegmatis led us to the discovery of a new class of bacteriostatic, highly hydrophobic antitubercular quinazolinones that potently inhibited the in vitro growth of either extracellular or i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d4519b2b8393fea7d0a03d992486fa
https://pubmed.ncbi.nlm.nih.gov/27671498
https://pubmed.ncbi.nlm.nih.gov/27671498
Autor:
Jerome Menegotto, Delphine Valente, Benjamin Podányi, Ida Szvoboda, Márta Venczel, Gabriella Ujhelyi, Klára Pintye-Hódi
Publikováno v:
Crystal Growth & Design. 12:1101-1110
The target of this article is to summarize the chemical and pharmaceutical (formulation) approaches that were found to be suitable for increasing the bioavailability of a model weak base (SAR1) wit...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f3b552bfbb495e718f2417c80a99156
https://doi.org/10.1021/cg200462g
https://doi.org/10.1021/cg200462g
Publikováno v:
Polymer. 42:4375-4383
The complex β dielectric relaxation process in amorphous poly(ethylene terephthalate) (PET) is investigated by thermally stimulated depolarization currents (TSDC) and isothermal depolarization currents (IDC) techniques. TSDC and IDC data are analyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45f3bf88fd9dffcee3aa36f91eebbb8d
https://doi.org/10.1016/s0032-3861(00)00732-1
https://doi.org/10.1016/s0032-3861(00)00732-1
Publikováno v:
Journal of Polymer Science Part B: Polymer Physics. 37:3494-3503
The dielectric secondary β relaxation process of poly(ethylene terephthalate) has been investigated by dielectric spectroscopy (DS) and thermally stimulated currents (TSC). To analyze the broad and asymmetric DS spectra, without previous assumptions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59b1bab3e0ff67e467f4c6929950901a
https://doi.org/10.1002/(sici)1099-0488(19991215)37:24<3494::aid-polb10>3.0.co
https://doi.org/10.1002/(sici)1099-0488(19991215)37:24<3494::aid-polb10>3.0.co
Publikováno v:
Ferroelectrics. 228:1-22
Dielectric spectroscopy (DS) and Thermally Stimulated Current (TSC) are employed to study the dynamics of Poly(VinyliDene Fluoride-TriFluoroEthylene) copolymers. Dielectric spectra reveal the existence of three relaxation processes: the β relaxation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350a92e6645a6357603c5c8383a515ef
https://doi.org/10.1080/00150199908226122
https://doi.org/10.1080/00150199908226122
Publikováno v:
Dielectric Materials for Electrical Engineering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51be13da0ed149cfffcb0117ae599005
https://doi.org/10.1002/9781118557419.ch04
https://doi.org/10.1002/9781118557419.ch04
Publikováno v:
Journal of pharmaceutical sciences. 93(1)
During the development of new pharmaceutical products based on drug substances in their amorphous form, the molecular mobility of an amorphous active ingredient was characterized in detail within a very broad time-temperature range. The relation betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f364cadf2c0d6685c000abf51c496a
https://pubmed.ncbi.nlm.nih.gov/14648651
https://pubmed.ncbi.nlm.nih.gov/14648651
Publikováno v:
10th International Symposium on Electrets (ISE 10). Proceedings (Cat. No.99 CH36256).
During the last decades, the frequency range of investigation of dielectric materials has been extended by many order of magnitude in the high frequency side. Actually, the reasonable accessible frequency range of dynamic dielectric spectrometers is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de3c8b6bd5a9cf42ce4543a15a01e946
https://doi.org/10.1109/ise.1999.832044
https://doi.org/10.1109/ise.1999.832044