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of 11
pro vyhledávání: '"Jerome Mahiou"'
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination assoc
Externí odkaz:
https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Ming Du, Ning Peng, Jamie R Wangen, Jianguo Chen, Rachel Green, Venkateshwar Mutyam, Yao Li, Kari Thrasher, Corinne E. Augelli-Szafran, Jerome Mahiou, Feng Liang, Jyoti Sharma, Lianwu Fu, Candice J. Coppola, Kim M. Keeling, Martin Mense, Eric M. Mendenhall, Jeong S. Hong, Hermann Bihler, Liping Tang, Robert Bostwick, Eric J. Sorscher, Bini Mathew, Josef Saltz, Steven M. Rowe, Andras Rab, Kaimao Liu, David M. Bedwell, Mark J. Suto, Eric Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation t
Autor:
B. Bostwick, Ning Peng, E. Mendenhall, M. Du, Eric Wong, David M. Bedwell, Kim M. Keeling, R. Green, K. Thrasher, Martin Mense, C. Coppola, Venkateshwar Mutyam, M. Suto, Eric J. Sorscher, Jerome Mahiou, L. Fu, J. Wangen, J. Chen, B. Mathew, Yao Li, A. Rab, Hermann Bihler, Jeong S. Hong, Steven M. Rowe, K. Liu, J. Sharma, J. Saltz, Feng Liang, L. Tang, C. Augelli-Szafran
Publikováno v:
Journal of Cystic Fibrosis. 20:S250-S251
Autor:
H. Valley, Martin Mense, Hermann Bihler, Eric Wong, Melissa M. Keenan, Jerome Mahiou, Feng Liang, Nikole J Jordan, Shuling Guo, Y. Cheng, Brett P. Monia, Lulu Huang
Publikováno v:
American journal of respiratory cell and molecular biology. 61(3)
The recessive genetic disease cystic fibrosis (CF) is caused by loss-of-function mutations in the CFTR (CF transmembrane conductance regulator) gene. Approximately 10% of patients with CF have at least one allele with a nonsense mutation in CFTR. Non
Autor:
Philip Thomas, Nikole J Jordan, Jerome Mahiou, Feng Liang, Andrey Sivachenko, Hermann Bihler, H. Valley, Alisa Bell, Martin Mense, Y. Cheng, Eric Wong, Katherine M. Bukis, Normand E. Allaire
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 18(4)
Background Assessment of approved drugs and developmental drug candidates for rare cystic fibrosis (CF)-causing variants of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) requires abundant material from relevant models. Methods Isogen
Autor:
Clayton R. Peterson, Herwig P. Moll, Renata Padilha Guedes, Christopher R. Longo, Elzbieta Kaczmarek, Maria B. Arvelo, Jerome Mahiou, Janis M. Taube, Cleide Goncalves da Silva, Christiane Ferran, Eduardo Rocha
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1833:1553-1561
A1/Bfl-1 is a NF-κB dependent, anti-apoptotic Bcl-2 family member that contains four Bcl-2 homology domains (BH) and an amphipathic C-terminal domain, and is expressed in endothelial cells (EC). Based on NF-κB reporter assays in bovine aortic EC, w
Autor:
Jerome Mahiou, Soizic Daniel, Tala Shukri, Maria B. Arvelo, David W. Sun, Shane T. Grey, Christiane Ferran, Christopher R. Longo, Virendra I. Patel, Gautam V. Shrikhande, Christina Mottley
Publikováno v:
Blood. 104:2376-2384
A20 is a stress response gene in endothelial cells (ECs). A20 serves a dual cytoprotective function, protecting from tumor necrosis factor (TNF)–mediated apoptosis and inhibiting inflammation via blockade of the transcription factor nuclear factor
Autor:
Eva Czismadia, Graziella Abu-Jawdeh, Shane T. Grey, Maria B. Arvelo, Soizic Daniel, Jerome Mahiou, Christopher R. Longo, Jeffrey T. Cooper, Christiane Ferran
Publikováno v:
Hepatology. 35:535-543
Apoptosis of hepatocytes is a seminal feature of fulminant hepatic failure. We show that the anti-apoptotic protein A20 is upregulated in hepatocytes by pro-inflammatory stimuli and functions to protect from apoptosis and limit inflammation by inhibi
Autor:
Jerome Mahiou, Peter Studer, Christiane Ferran, Suzhuei W. Wilson, Averil Ma, Cleide Goncalves da Silva, Virendra I. Patel, Darlan C. Minussi, Marco Skroch, Clayton R. Peterson, Eva Csizmadia
Publikováno v:
Hepatology (Baltimore, Md.). 57(5)
Liver regeneration is of major clinical importance in the setting of liver injury, resection, and transplantation. A20, a potent antiinflammatory and nuclear factor kappa B (NF-κB) inhibitory protein, has established pro-proliferative properties in
Autor:
Virendra I. Patel, Maria B. Arvelo, Soizic Daniel, Jerome Mahiou, Christiane Ferran, Christopher R. Longo, Shane T. Grey
Publikováno v:
Circulation. 108(9)
Background— CD40/CD40 ligand (CD40L) signaling is a potent activator of endothelial cells (ECs) and promoter of atherosclerosis. In this study, we investigate whether A20 (a gene we have shown to be antiinflammatory and antiapoptotic in ECs) can pr