Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jerome JA"'
Autor:
Jeroen FJ Bogie, Elien Grajchen, Elien Wouters, Bieke Broux, Piet Stinissen, Bart Van Wijmeersch, Jerome JA Hendriks
Publikováno v:
Therapeutic Advances in Chronic Disease, Vol 11 (2020)
Background and aims: Alemtuzumab is a humanized monoclonal antibody that depletes CD52-bearing B and T lymphocytes. Clinical trials defined that systemic administration of alemtuzumab reduces disease severity in the relapsing–remitting phase of mul
Externí odkaz:
https://doaj.org/article/3ae8c169458b4b00b08682803ec072b5
Autor:
Vladimir Ugorets, Paul-Lennard Mendez, Dmitrii Zagrebin, Giulia Russo, Yannic Kerkhoff, Georgios Kotsaris, Jerome Jatzlau, Sigmar Stricker, Petra Knaus
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110630- (2024)
Summary: Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells. The transformation of proliferative muscle proge
Externí odkaz:
https://doaj.org/article/e6878bb5d4dc4feca4d91dec25309444
Autor:
Bogie, Jeroen FJ, Grajchen, Elien, Wouters, Elien, Bieke Broux, Stinissen, Piet, Wijmeersch, Bart Van, Hendriks, Jerome JA
Supplemental material, Supplementary_figure_and_table for CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis by Jeroen FJ Bogie, Elien Grajchen, Elien Wouters, Bieke Broux, Piet Stinissen,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765f161d91c1282c06bb2f33fa251d57
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102859- (2024)
Summary: Chromatin accessibility influences gene regulation and can be quantified using assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). Recapitulating in vivo fluid shear stress (FSS) mechano-regimes in vitro al
Externí odkaz:
https://doaj.org/article/1058e14ac710475589f453c56254689d
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract It is widely known that antiferromagnets (AFMs) display a high frequency response in the terahertz (THz) range, which opens up the possibility for ultrafast control of their magnetization for next generation data storage and processing appli
Externí odkaz:
https://doaj.org/article/8efb0f56aa744295b0334c8c30843805
Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
Autor:
Uirá Souto Melo, Jerome Jatzlau, Cesar A. Prada-Medina, Elisabetta Flex, Sunhild Hartmann, Salaheddine Ali, Robert Schöpflin, Laura Bernardini, Andrea Ciolfi, M-Hossein Moeinzadeh, Marius-Konstantin Klever, Aybuge Altay, Pedro Vallecillo-García, Giovanna Carpentieri, Massimo Delledonne, Melanie-Jasmin Ort, Marko Schwestka, Giovanni Battista Ferrero, Marco Tartaglia, Alfredo Brusco, Manfred Gossen, Dirk Strunk, Sven Geißler, Stefan Mundlos, Sigmar Stricker, Petra Knaus, Elisa Giorgio, Malte Spielmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in which signaling pathways such as BMP, TGFβ and WNT are known key players in driving ectopic bone formation. Identifying novel genes and pathways rel
Externí odkaz:
https://doaj.org/article/4848e7ed684e495f8ace27fcba8b8f77
Autor:
Mustafa Ilhan, Nurcan Hastar, Branka Kampfrath, Deniz Neslihan Spierling, Jerome Jatzlau, Petra Knaus
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4593 (2024)
Increased expression and nuclear translocation of β-CATENIN is frequently observed in breast cancer, and it correlates with poor prognosis. Current treatment strategies targeting β-CATENIN are not as efficient as desired. Therefore, detailed unders
Externí odkaz:
https://doaj.org/article/d31fd4254ace4bb2a02f94c81143a05d
Autor:
Jerome Jatzlau, Paul-Lennard Mendez, Aybuge Altay, Lion Raaz, Yufei Zhang, Sophia Mähr, Akin Sesver, Maria Reichenbach, Stefan Mundlos, Martin Vingron, Petra Knaus
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107405- (2023)
Summary: Bone morphogenetic protein (BMP) signaling and fluid shear stress (FSS) mediate complementary functions in vascular homeostasis and disease development. It remains to be shown whether altered chromatin accessibility downstream of BMP and FSS
Externí odkaz:
https://doaj.org/article/d3aa69edba6440b8ab59fccf51ddb428
Autor:
Kamal Gautam, Kiran Paudel, Jerome Jacobs, Jeffrey A Wickersham, Wan Mohd Ikhtiaruddin, Iskandar Azwa, Rumana Saifi, Sin How Lim, Roman Shrestha
Publikováno v:
JMIR Formative Research, Vol 7, p e48113 (2023)
BackgroundChemsex—the use of psychoactive drugs to enhance the sexual experience—is an increasing phenomenon globally. Despite the increasing burden and associated harms of chemsex, evidence-based interventions (ie, behavioral and pharmacological
Externí odkaz:
https://doaj.org/article/a3e8bcf39ea54da9ba6fcb0b7844af39
Autor:
Ingrid Quist-Løkken, Clara Andersson-Rusch, Martin Haugrud Kastnes, Jürgen Markus Kolos, Jerome Jatzlau, Hanne Hella, Oddrun Elise Olsen, Anders Sundan, Petra Knaus, Felix Hausch, Toril Holien
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 with drugs such as t
Externí odkaz:
https://doaj.org/article/1d7144747e7f4e01a14dd611f82ff44b