Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Jerome Irianto"'
Autor:
Gengqiang Xie, Maria Pilar Toledo, Xue Hu, Hyo Jeong Yong, Pamela Sandoval Sanchez, Chengyang Liu, Ali Naji, Jerome Irianto, Yue J. Wang
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Current approaches to profile the single-cell transcriptomics of human pancreatic endocrine cells almost exclusively rely on freshly isolated islets. However, human islets are limited in availability. Furthermore, the extensive pr
Externí odkaz:
https://doaj.org/article/3d422116a8064f6a8eb95b7ea0f0f65f
Autor:
Olalekan H. Usman, Liting Zhang, Gengqiang Xie, Hemant M. Kocher, Chang-il Hwang, Yue Julia Wang, Xian Mallory, Jerome Irianto
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract The establishment of patient-derived pancreatic cancer organoid culture in recent years creates an exciting opportunity for researchers to perform a wide range of in vitro studies on a model that closely recapitulates the tumor. One of the o
Externí odkaz:
https://doaj.org/article/3a41ca1bac8a43188228952c1df43c8d
Autor:
Hyo Jeong Yong, Gengqiang Xie, Chengyang Liu, Wei Wang, Ali Naji, Jerome Irianto, Yue J. Wang
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
NEUROGENIN3+ (NEUROG3+) cells are considered to be pancreatic endocrine progenitors. Our current knowledge on the molecular program of NEUROG3+ cells in humans is largely extrapolated from studies in mice. We hypothesized that single-cell RNA-seq ena
Externí odkaz:
https://doaj.org/article/ec5087b5e5784e34af299c119b9f8477
Autor:
Brandon H. Hayes, Peter Kuangzheng Zhu, Mai Wang, Charlotte R. Pfeifer, Yuntao Xia, Steven Phan, Jason C. Andrechak, Junhong Du, Michael P. Tobin, Alisya Anlas, Lawrence J. Dooling, Manasvita Vashisth, Jerome Irianto, Michael A. Lampson, Dennis E. Discher
Publikováno v:
Journal of Cell Science.
A cell's mechanical environment can have many effects, but whether it impacts a cell's DNA sequence has remained unclear. To investigate this, we developed a live-cell method to measure changes in chromosome numbers. We edited constitutive genes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5356d9a2def24255ced16711a66b819
https://doi.org/10.1242/jcs.260753
https://doi.org/10.1242/jcs.260753
Autor:
Lawrence J. Dooling, Jason C. Andrechak, Brandon H. Hayes, Siddhant Kadu, William Zhang, Ruby Pan, Manasvita Vashisth, Jerome Irianto, Cory M. Alvey, Leyuan Ma, Dennis E. Discher
Publikováno v:
Nature Biomedical Engineering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d9fa43c688748d859e1916dcca7c2d
https://doi.org/10.1038/s41551-023-01031-3
https://doi.org/10.1038/s41551-023-01031-3
Autor:
Brandon H Hayes, Peter Kuangzheng Zhu, Mai Wang, Charlotte R Pfeifer, Yuntao Xia, Steven Phan, Jason C Andrechak, Junhong Du, Michael P Tobin, Alisya Anlas, Lawrence Dooling, Manasvita Vashisth, Jerome Irianto, Michael A. Lampson, Dennis E Discher
Matrix around cells exerts many effects, some of which depend on the putative tumor suppressor Myosin-II, but whether such factors affect DNA sequences in a cell remains unclear. Here, live-cell monitoring of changes to chromosome copy numbers is dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a43bba16d4157aa501f4d0ab23445cf
https://doi.org/10.1101/2023.02.25.530049
https://doi.org/10.1101/2023.02.25.530049
Autor:
Gengqiang Xie, Olalekan H Usman, Sampath Kumar, Dhenu Patel, Megan Kavanaugh, Yue Julia Wang, Jerome Irianto
Intratumor phenotypic, genomic, and transcriptomic heterogeneity in pancreatic cancer have been reported by multiple studies; however, little is known about the heterogeneity’s underlying mechanisms. One possible approach to studying this is to per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::037d13160055ab577d5a3cff7b8ff741
https://doi.org/10.1101/2022.11.11.516211
https://doi.org/10.1101/2022.11.11.516211
Autor:
Olalekan H Usman, Sampath Kumar, Reddick R Walker, Gengqiang Xie, AbdelAziz R. Jalil, Subramanian Ramakrishnan, Lawrence J. Dooling, Yue Julia Wang, Jerome Irianto
Pancreatic cancer adenocarcinoma (PDAC) has been reported to be the third highest cause of cancer-related deaths in the United States. PDAC is known for its high proportion of stroma which accounts for 90% of the tumor mass. The stroma is made up of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d09e30d768ed99f3a6ff93229c70a31
https://doi.org/10.1101/2022.11.11.516201
https://doi.org/10.1101/2022.11.11.516201
Autor:
Isabella Leite Coscarella, Prescott B. Chase, Lili Wang, Bjorn C. Knollmann, Jerome Irianto, J. Renato D. Pinto
Publikováno v:
Biophysical Journal. 122:405a-406a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::825aac2ae8e50ef585feab5a56e5c209
https://doi.org/10.1016/j.bpj.2022.11.2205
https://doi.org/10.1016/j.bpj.2022.11.2205
Single-cell DNA sequencing enables the construction of evolutionary trees that can reveal how tumors gain mutations and grow. Different whole genome amplification (WGA) procedures render genomic materials of different characteristics, often suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4c5bc9675a9fe98f69ebdb74354037
https://doi.org/10.1101/2022.08.26.505465
https://doi.org/10.1101/2022.08.26.505465