Výsledky vyhledávání - "Jerome H. Fleisch"

Inhibition of antigen-induced arthritis in guinea pigs by a selective LTB4 receptor antagonist LY293111Na

Autor: Kenji Kuwabara, Y. Hori, H. Jyoyama, Jerome H. Fleisch

Publikováno v: Inflammation Research. 51:541-550

Objective and design: To investigate the role of leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in the development and progression of antigen-induced arthritis (AIA) in guinea pigs and rats.¶Methods: Arthritis was induced by injecting cationic am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb481fd0546b4f0e1b57fe92195b2e6
https://doi.org/10.1007/pl00012425

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Effects of leukotriene B 4 receptor antagonist, LY293111Na, on antigen-induced bronchial hyperresponsiveness and leukocyte infiltration in sensitized guinea pigs

Autor: Kenji Kuwabara, Y. Furue, Jerome H. Fleisch, Y. Hori, F. Asanuma, A. Arimura

Publikováno v: Inflammation Research. 50:136-141

Objective and Design: LY293111Na, 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy] propoxy] - phenoxy]-benzoic acid sodium salt, is a novel leukotriene B4 (LTB4) receptor antagonist. Its effects on guinea pig models of asthma were compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a835027d99182570610ec72bd5aa7d
https://doi.org/10.1007/s000110050737

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Effects of the second-generation leukotriene B4 receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice

Autor: Hirokuni Jyoyama, Yozo Hori, Toshiyuki Maruyama, Kiyoshi Yasui, Jerome H. Fleisch, Kenji Kuwabara

Publikováno v: European Journal of Pharmacology. 402:275-285

The effects of the second-generation leukotriene B 4 receptor (LTB 4 receptor) antagonist, 2-[2-propyl-3-{3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxy-phenoxy]-propoxy}phenoxy]benzoic acid sodium salt (LY293111Na), on leukotriene B 4 -induced leukocyte in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0de1b5d1ceb4f9166443df53a6eca9
https://doi.org/10.1016/s0014-2999(00)00518-5

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ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia

Autor: David Lodge, Tracey K. Murray, Dell Colin Peter, Jaipal Singh, Todd R. Wiernicki, Deborah R. McCarty, Jerome H. Fleisch, David J. Osborne, Michael J. O'Neill, Kelly E. Patrick, Carlos R. Roman, Mark A Ward, Caroline A Hicks

Publikováno v: Brain Research. 871:234-244

In the present studies, we have evaluated the effects of N-[4-(2-¿[(3-Chlorophenyl)methyl]amino¿ethyl)phenyl]-2-thiophenecarbo ximidamide dihydrochloride (ARL 17477) on recombinant human neuronal NOS (nNOS) and endothelial NOS (eNOS). We then carri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f88110df04702ead135a77896f33236
https://doi.org/10.1016/s0006-8993(00)02471-9

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Quinoline-substituted dihydroindoles as cysLT1 (LTD4 receptor) antagonists

Autor: J. Scott Sawyer, Sandra L. Cockerham, K. Jeff Thrasher, Larry L. Froelich, Carlos R. Roman, Bach Nicholas J, Peter W. Stengel, Jerome H. Fleisch, Steven A. Silbaugh

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:249-252

A series of quinoline-substituted dihydroindoles has been synthesized and evaluated as antagonists of the cysLT 1 receptor. This series, exemplified by 2 (LY302905; pKi = 8.3 for inhibition of binding of 3 H-LTD 4 to guinea pig lung membranes), repre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::438717985a22985e2fc666797a7adefa
https://doi.org/10.1016/0960-894x(96)00013-3

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2-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol leukotriene B4 receptor antagonists

Autor: Michael J. Sofia, David K. Herron, Katrina Ann Nelson, Philip Marder, Theodore Goodson, Jerome H. Fleisch, Larry L. Froelich, Carlos R. Roman, Stephen M. Spaethe

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1995-2000

A series of 2-n-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenols were prepared and shown to be potent leukotriene B4 (LTB4) receptor antagonists. They bound to the human neutrophil and guinea pig lung LTB4 receptors with high affinity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a1f669ee07c369a26013a3dcb87d5bd
https://doi.org/10.1016/0960-894x(95)00340-y

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Acid unit modifications of 1,2,4,5-substituted hydroxyacetophenones and the effect on in vitro and in vivo LTB4 receptor antagonism

Autor: Larry L. Froelich, Carlos R. Roman, Sandra L. Cockerham, Floreancig Paul Edward, William T. Jackson, Philip Marder, Michael J. Sofia, Peter W. Stengel, Steven A. Silbaugh, Jerome H. Fleisch, David L. Saussy

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:1147-1152

7-[4-Acetyl-2-ethyl-5-hydroxyphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid sodium salt 7 (LY247826) and several 7-[3-(4-acetyl-2-ethyl-5-hydroxyphenoxy)propoxy)-2-propylphenoxy] acetic acid analogues were prepared as LTB4 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06bce8a25799f50a6136a6998c69220c
https://doi.org/10.1016/s0960-894x(00)80304-2

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