Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jerome Guillemont"'
Autor:
Anna C Haagsma, Ioana Podasca, Anil Koul, Koen Andries, Jerome Guillemont, Holger Lill, Dirk Bald
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23575 (2011)
Infections with Mycobacterium tuberculosis are substantially increasing on a worldwide scale and new antibiotics are urgently needed to combat concomitantly emerging drug-resistant mycobacterial strains. The diarylquinoline TMC207 is a highly promisi
Externí odkaz:
https://doaj.org/article/c984effecc89411ab72dc82c07f6ee33
Autor:
Sabrina Quatrevaux, Jerome Guillemont, Sandrine Gaurrand, Laurence Queguiner, Michaut Antoine Benjamin
Publikováno v:
Letters in Organic Chemistry. 19:602-607
Abstract: The synthesis of advanced substituted 3-pentafluorosulfanylphenol/anisole was accomplished starting from the easy to access and commercially available 3-pentafluorosulfanylphenol. These products bear diverse substitutions such as ester, ald
Autor:
Pierre Sierocki, Krystal Gaillard, Ruben Arturo Arellano Reyes, Chloé Donnart, Emilie Lambert, Sandrine Grosse, Laurence Arzel, Arnaud Tessier, Jerome Guillemont, Monique Mathé-Allainmat, Jacques Lebreton
Publikováno v:
Organic & Biomolecular Chemistry. 20:2715-2728
We report the synthesis of C-nucleosides with a quaternary carbon at the anomeric position tethered to a 4-substituted 1,2,3-triazole ring and a cyano group, which were developed as potential antiviral agents.
Autor:
Pierre, Sierocki, Krystal, Gaillard, Ruben Arturo, Arellano Reyes, Chloé, Donnart, Emilie, Lambert, Sandrine, Grosse, Laurence, Arzel, Arnaud, Tessier, Jerome, Guillemont, Monique, Mathé-Allainmat, Jacques, Lebreton
Publikováno v:
Organicbiomolecular chemistry. 20(13)
A linear sequence to access a novel series of
Autor:
Laurence Queguiner, Carlos Afonso, Jerome Guillemont, Eric Arnoult, David Speybrouck, Virginie Domalain, Marie Hubert-Roux, Dany Jeanne Dit Fouque
Publikováno v:
European Journal of Mass Spectrometry
European Journal of Mass Spectrometry, IM Publications, 2019, 25 (3), pp.291-299. ⟨10.1177/1469066718813226⟩
European Journal of Mass Spectrometry, IM Publications, 2019, 25 (3), pp.291-299. ⟨10.1177/1469066718813226⟩
International audience; Mycobacterium tuberculosis infection results in more than two million deaths per year and is the leading cause of mortality in people infected with HIV. A new structural class of antimycobacterials, the diarylquinolines, has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193463214cb8e11c02132a54dc59c707
https://hal-normandie-univ.archives-ouvertes.fr/hal-02330535
https://hal-normandie-univ.archives-ouvertes.fr/hal-02330535
Publikováno v:
Current bioactive compounds
Tuberculosis (TB) remains one of the most deadly infectious diseases in the world, killing about 2 million people per year, and mostly affecting the worlds poorest population. The length of current regimens for treatment of TB is long (6-9 months) wi
Autor:
Chi Hung Nguyen, Edward Arnold, Alain Philippe Poncelet, David Grierson, Stephen H. Hughes, Daniel M. Himmel, Said Oumouch, Christophe Meyer, Sophie Coupa, Jerome Guillemont, Abdellah Benjahad, Koen Andries, Kalyan Das, Arthur D. Clark, Csoka Imre Christian Francis
Publikováno v:
Journal of medicinal chemistry
In the treatment of AIDS, the efficacy of all drugs, including non-nucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT), has been limited by the rapid appearance of drug-resistant viruses. Lys103Asn, Tyr181Cys, and Tyr188Leu are some of
This chapter discusses the non-nucleoside reverse transcriptase inhibitors (NNRTI), which is a valuable component of first-line highly active antiretroviral therapy (HAART) today. Reverse transcriptase (RT) is an essential enzyme in the replication c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7651bebb5ccd325c02d2f801bd7fe7d9
https://doi.org/10.1128/9781555815493.ch3
https://doi.org/10.1128/9781555815493.ch3
Autor:
Paul J. Lewi, Jan Heeres, Vandenput Dirk Alfons Leo, Ruben Gerardus George Leenders, Jerome Guillemont
Publikováno v:
ChemInform. 43
Sterically hindered, electron-deficient anilines couple to the 6-position of the purine core only if activated as their corresponding TFA-amides [cf.
Autor:
David Francis Alain Lançois, Ovidiu Pop, Kristien Bonroy, Nacer Lounis, W Balemans, Dirk Bald, Koen Andries, Anil Koul, Jerome Guillemont, Ron Gilissen, Karen Vergauwen, Miguel F.C. De Bolle, Luc Vranckx, Magali Madeleine Simone Motte, Selena Mol, Holger Lill
Publikováno v:
Antimicrobial agents and chemotherapy
Emergence of drug-resistant bacteria represents a high, unmet medical need, and discovery of new antibacterials acting on new bacterial targets is strongly needed. ATP synthase has been validated as an antibacterial target in Mycobacterium tuberculos