Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jerome F. Hayes"'
Publikováno v:
Angewandte Chemie. 132:6806-6810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::966559c1fa4d2396ee757bf4a37dd1bb
https://doi.org/10.1002/ange.201915944
https://doi.org/10.1002/ange.201915944
Autor:
Graham W. Rutherford, Maciej M. Kucharski, Eneritz Fernandez-Puertas, Lee Edwards, Katherine Wheelhouse, Antonella Carangio, Glynn D. Williams, Jerome F. Hayes
Publikováno v:
Organic Process Research & Development. 24:1909-1915
Nine sponge nickel catalysts were assessed for the reduction of an aliphatic nitro group in a trickle bed reactor. Focused beam reflectance measurement (FBRM) was used to assess the mechanical stre...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::031fb9d00a9bc9b48a421065954fd6ef
https://doi.org/10.1021/acs.oprd.9b00447
https://doi.org/10.1021/acs.oprd.9b00447
A scalable metal-, azide-, and halogen-free method for the synthesis of substituted 1,2,3-triazoles has been developed. The reaction proceeds through a 3-component coupling of α-ketoacetals, tosyl hydrazide, and a primary amine. The reaction shows o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633e745247abfcc1ab3e023022781e09
https://strathprints.strath.ac.uk/71811/1/Clark_etal_ACIE_2020_A_scalable_metal_azide_and_halogen_free_method_for_the_preparation_of_triazoles.pdf
https://strathprints.strath.ac.uk/71811/1/Clark_etal_ACIE_2020_A_scalable_metal_azide_and_halogen_free_method_for_the_preparation_of_triazoles.pdf
Autor:
Erica Vit, Jerome F. Hayes, Francois-Rene Alexandre, Cyril B. Dousson, Christophe Claude Parsy, David D. Pascoe, Catherine Caillet, Marie-Pierre Lioure, Neil Hodnett, Elodie Rosinovsky, John Edward Richardson, Guillaume Bret, Stéphanie Bot, Agnès Amador, Gary T. Borrett, Bernadette Choudary, Arlène Roland, Daniel Da Costa, Alan Ironmonger, John D. Hayler, Augustine Ochen, Séverine Bonaric, David Colclough, Richard K. Bellingham
Publikováno v:
Organic Process Research & Development. 22:200-206
A new and improved synthetic route to an intermediate in the synthesis of the phosphinate ester GSK2248761A is described. In the key step, we describe the first process-scale example of a palladium-catalyzed phosphorus–carbon coupling to give the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17aba0e5462710cfa14470fea5b10eb
https://doi.org/10.1021/acs.oprd.7b00356
https://doi.org/10.1021/acs.oprd.7b00356
Autor:
David D. Pascoe, John D. Hayler, Alistair Stewart, Erica Vit, Jingyang Wang, Etridge Stephen K, Celine Bret, Alan Ironmonger, Elaine Smith, Neil Hodnett, Jerome F. Hayes, Adel Moussa, Benjamin Alexander Mayes, Jonathan Stanway
Publikováno v:
Organic Process Research & Development. 22:207-211
Amidation of indole 2-carboxylate 1 with ammonia gas via the imidazolide 2 gave GSK2248761A API 3, which was in development for the treatment of HIV. Three significant impurities, namely the phosphinic acid 4, the N-acyl urea 8, and the indoloyl carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d738e029ca3bcdc1a2aa848d8a5c8d5
https://doi.org/10.1021/acs.oprd.7b00357
https://doi.org/10.1021/acs.oprd.7b00357
Autor:
Guillaume Roux, Fiona Rawlinson, Alcide Perboni, Michael Anthony Forth, Darren Caine, Adam Banks, Christopher Drake, Matthew E. Popkin, Jerome F. Hayes, John S. Carey, Asa Gladwin, Paolo Maragni, Gary F. Breen, David O. Morgan, Paul Oxley, Simone Guelfi
Publikováno v:
Organic Process Research & Development. 13:1130-1140
A synthetic route amenable to large-scale synthesis of the glycine antagonist (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-pyyrrolidin-3-ylidene)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-penta-ol 12 is presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65eeaaa75ed92bd7ee297cccea3b6a82
https://doi.org/10.1021/op9001824
https://doi.org/10.1021/op9001824
Autor:
Jerome F. Hayes, Michael Shipman, Sabitur Rahman, Gildas Prie, Natacha Prevost, Cyril Montagne, Jason J. Shiers
Publikováno v:
Tetrahedron. 62:8447-8457
2-Methyleneaziridinyl anions can be produced by selective deprotonation of the parent aziridine at C-3 using sec-BuLi/TMEDA. Subsequent reaction with a wide variety of electrophiles including MeI, ICH2CH2CH2CH2Cl, PhCH2Br, allyl bromide, Me3SiCl, Bu3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b220ebdbf739630293126f3e2f5edc
https://doi.org/10.1016/j.tet.2006.06.083
https://doi.org/10.1016/j.tet.2006.06.083
Autor:
Jean-Baptiste Clement, Helen M. Sheldrake, Andrew S. Wells, Peter W. Sheldrake, Jerome F. Hayes
Publikováno v:
Synlett. 2001:1423-1427
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0148f867675457ab8ec62ec98813e9e8
https://doi.org/10.1055/s-2001-16780
https://doi.org/10.1055/s-2001-16780
Publikováno v:
Organic Process Research & Development. 3:60-63
Palladium-catalysed aminocarbonylation of a 7-bromo- or 7-iodo-1,4-benzodiazepine with N-Cbz-4,4‘-bipiperidine hydrochloride efficiently introduced the 7-(4,4‘-bipiperidinylcarbonyl) moiety of (2S)...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a85bca4f538d8a6ca64cfbc5aa93167
https://doi.org/10.1021/op980068n
https://doi.org/10.1021/op980068n
Publikováno v:
Synlett. 2006:2716-2718
A new synthetic approach to a potent CRF antagonist, GW808990 (NBI35583), is reported. The route hinges on the palladium-catalysed intramolecular arylation of a urea with 2-chloropyridine. Spontaneous piperazine ring closure means that a high-yieldin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27aebe96ac32f38c2318bf28be3fb5fc
https://doi.org/10.1055/s-2006-950276
https://doi.org/10.1055/s-2006-950276