Neuron-Specific Deletion of Scrib in Mice Leads to Neuroanatomical and Locomotor Deficits

Autor: Jerome Ezan, Maité M. Moreau, Tamrat M. Mamo, Miki Shimbo, Maureen Decroo, Nathalie Sans, Mireille Montcouquiol

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Scribble (Scrib) is a conserved polarity protein acting as a scaffold involved in multiple cellular and developmental processes. Recent evidence from our group indicates that Scrib is also essential for brain development as early global deletion of S

Externí odkaz: https://doaj.org/article/ad91701f1b094518ad0dc666681173e0

The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling

Autor: Ana Dorrego-Rivas, Jerome Ezan, Maïté M. Moreau, Sonia Poirault-Chassac, Nathalie Aubailly, Julie De Neve, Camille Blanchard, Francis Castets, Amélie Fréal, Arne Battefeld, Nathalie Sans, Mireille Montcouquiol

Publikováno v: Science advances, 8(36):eabo6333, 1-21. American Association for the Advancement of Science
Dorrego-Rivas, A, Ezan, J, Moreau, M M, Poirault-Chassac, S, Aubailly, N, De Neve, J, Blanchard, C, Castets, F, Fréal, A, Battefeld, A, Sans, N & Montcouquiol, M 2022, ' The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling ', Science advances, vol. 8, no. 36, eabo6333, pp. 1-21 . https://doi.org/10.1126/sciadv.abo6333
Science Advances
Science Advances, 2022, 8 (36), ⟨10.1126/sciadv.abo6333⟩

International audience; Core planar cell polarity (PCP) genes, which are involved in various neurodevelopmental disorders such as neural tube closure, epilepsy, and autism spectrum disorder, have poorly defined molecular signatures in neurons, mostly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a5bf3de94e6e8ed997abe50e47d4ba
https://doi.org/10.1126/sciadv.abo6333

Scribble controls social behaviors through the regulation of the ERK/Mnk1 pathway

Autor: Sylvain Miraux, Benjamin J.A. Robert, Jerome Ezan, Maïté M. Moreau, Nathalie Sans, Yoon H. Cho, Mireille Montcouquiol, Susanna Pietropaolo, Marlène Maitre, Wim E. Crusio

Social behavior is a basic domain affected in several neurodevelopmental disorders. Indeed, deficits in social interest, interactions and recognition represent core symptoms of Autism Spectrum Disorder but are also found associated with a heterogeneo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd76ffe0b785cff37bd2a8e7b3e54a7e
https://hal.archives-ouvertes.fr/hal-03029888/file/2020.09.10.289397v1.full.pdf

Early loss of Scribble affects cortical development and interhemispheric connectivity resulting in psychomotor dysregulation

Autor: Maïté M. Moreau, Rivka A. Rachel, Ronan Peyroutou, Fadel Tissir, Froylan Calderon de Anda, Nathalie Sans, Miki Shimbo, Jerome Ezan, Maureen Decroo, Mireille Montcouquiol, Melanie Richter, Tamrat M. Mamo

Neurodevelopmental disorders arise from combined defects in processes including cell proliferation, differentiation, migration and commissure formation. The evolutionarily conserved tumor-suppressor protein Scribble (Scrib) serves as a nexus to trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b31290e677574a5c19a75a39277bcc1
https://doi.org/10.1101/780130

Les liens multiples entre les cils et la polarité planaire cellulaire

Autor: Mireille Montcouquiol, Jerome Ezan

Publikováno v: médecine/sciences. 30:1004-1010

Since our seminal study in 2003, much has been written about core planar cell polarity (core PCP) signaling and the inner ear. In just a few years, and using the inner ear as a model system, our understanding of the molecular basis of this signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06f147f26a0094788799e43f8ea374cf
https://doi.org/10.1051/medsci/20143011015