Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jerome Escano"'
Autor:
Akshaya Ravichandran, Ravi S. Orugunty, Leif Smith, Jung Hwa Lee, Jerome Escano, Shi-En Lu, Matthew K. Ross, Frank W. Austin
Publikováno v:
Antimicrob Agents Chemother
Occidiofungin is a nonribosomally synthesized cyclic lipopeptide that possesses broad-spectrum antifungal properties at submicromolar concentrations. This report explores multiple routes of administration and formulations of occidiofungin, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443567ad7e5ef9569be1d02375dc3e21
https://europepmc.org/articles/PMC7674058/
https://europepmc.org/articles/PMC7674058/
Mutacin 1140, a member of the epidermin family of type AI lantibiotics, has a broad spectrum of activity against Gram-positive bacteria. It blocks cell wall synthesis by binding to lipid II. Although it has rapid bactericidal effects and potent activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5099fd896f84fd7eead4bb0e46d89670
https://europepmc.org/articles/PMC6256755/
https://europepmc.org/articles/PMC6256755/
Publikováno v:
Journal of Bacteriology. 197:1173-1184
Lantibiotics are ribosomally synthesized peptide antibiotics composed of an N-terminal leader peptide that is cleaved to yield the active antibacterial peptide. Significant advancements in molecular tools that promote the study of lantibiotic biosynt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da3bece761e713b6f557f8938eae139
https://doi.org/10.1128/jb.02531-14
https://doi.org/10.1128/jb.02531-14
Publikováno v:
Applied and environmental microbiology. 83(14)
Mutacin 1140 belongs to the epidermin group of lantibiotics. Epidermin class lantibiotics are ribosomally synthesized and posttranslationally modified antibiotics with potent activity against Gram-positive bacteria. In particular, this class is effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80587271d5c4f75373003687fe7bf376
https://pubmed.ncbi.nlm.nih.gov/28500042
https://pubmed.ncbi.nlm.nih.gov/28500042
Autor:
Bo Li, Wilfred A. van der Donk, Sonia I. Maffioli, Stefano Donadio, Subha Mukherjee, Dillon P. Cogan, Leif Smith, Jerome Escano, Margherita Sosio, Neha Garg, Satish K. Nair, Gabrielle N. Thibodeaux, Manuel A. Ortega
Lantibiotics are ribosomally synthesized and post-translationally modified antimicrobial peptides containing thioether rings. In addition to these crosslinks, the clinical candidate lantibiotic NAI-107 also possesses a C-terminal S-[(Z)-2-aminovinyl]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f47671f6d43d3735161d43b80a3f69
https://europepmc.org/articles/PMC5315687/
https://europepmc.org/articles/PMC5315687/
Publikováno v:
MicrobiologyOpen
Lantibiotics are ribosomally synthesized peptide antibiotics composed of an N-terminal leader peptide that promotes the core peptide's interaction with the post translational modification (PTM) enzymes. Following PTMs, mutacin 1140 is transported out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3429d5151ce00f72fb0d15b4aafb2427
https://doi.org/10.1002/mbo3.222
https://doi.org/10.1002/mbo3.222
Autor:
Stephen B. Pruett, Akshaya Ravichandran, Shi-En Lu, Jerome Escano, Jim Cooley, Frank W. Austin, Leif Smith, Steven Lai Hing
Publikováno v:
Pharmacology & Pharmacy. :1085-1093
Occidiofungin, a glyco-lipopeptide obtained from the liquid culture of Burkholderia contaminans MS14, has been identified as a novel fungicide. The natural product was shown to have a minimal amount of toxicity in a previous mouse toxicity study foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1258c2a1fb8395e97f165b359883bf9
https://doi.org/10.4236/pp.2014.511118
https://doi.org/10.4236/pp.2014.511118
Autor:
Leif Smith, Jerome Escano
Publikováno v:
Expert opinion on drug discovery. 10(8)
Lantibiotics are a class of ribosomally and post-translationally modified peptide antibiotics that are active against a broad spectrum of Gram-positive bacteria. Great efforts have been made to promote the production of these antibiotics, so that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e029cea1e297f9ee8ff37e5d8294a3f9
https://pubmed.ncbi.nlm.nih.gov/26004576
https://pubmed.ncbi.nlm.nih.gov/26004576
Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity produced by the Gram-negative bacterium Burkholderia contaminans. The biosynthetic gene cluster was confirmed to contain two cyclase thioesterases. NM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3d89b6afe17d564055e38353399341
https://europepmc.org/articles/PMC4142711/
https://europepmc.org/articles/PMC4142711/