Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jerome E. Bakke"'
Publikováno v:
Xenobiotica. 24:909-919
1. Dosing rats with the gamma-glutamyl-transpeptidase inhibitor AT-125 results in the excretion of free glutathione in the urine of rat: this treatment did not lead to the excretion of glutathione conjugates of orally dosed xenobiotics, neither did A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c634327372502116b8f9ea10f0cdb201
https://doi.org/10.3109/00498259409043289
https://doi.org/10.3109/00498259409043289
Publikováno v:
Chemosphere. 38(8)
Colostomized chickens given oral doses of 3,5-dinitrobenzamide (nitromide) cleared nitromide predominantly through the urine (58% of dose) and feces (21% of dose). Rats cleared 52% of nitromide via urinary excretion and 44% via feces. Major urinary m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9518947fd4d90074594201e5d9a53eec
https://pubmed.ncbi.nlm.nih.gov/10101847
https://pubmed.ncbi.nlm.nih.gov/10101847
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 28(10)
1. Nearly 70% of single oral doses of 14C-labelled pentachloronitrobenzene (PCNB) was excreted in bile within 24 h. 2. The characterized biliary metabolites of PCNB were either mercapturic acid pathway metabolites or catabolites thereof (thiols, meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988f1af0447585beedbe219656a09ba9
https://pubmed.ncbi.nlm.nih.gov/9849644
https://pubmed.ncbi.nlm.nih.gov/9849644
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 23(8)
1. Sex differences observed in the metabolism of pentachlorothioanisole in rat were due to: (1) greater excretion in urine by females, and greater biliary excretion by males; (2) formation of pentachlorophenyl mercapturic acid pathway metabolites by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3565ccdc39559febc5b1cd0b90df393
https://pubmed.ncbi.nlm.nih.gov/8284949
https://pubmed.ncbi.nlm.nih.gov/8284949
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(4)
1. 14C-Cysteinyl- and homocysteinylpropachlor were metabolized to their respective mercapturic acids by rat kidneys in situ. First-pass elimination of 14C in urine was 47.5% for the cysteine conjugate and 36% for the homocysteine conjugate. 2. About
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a113b902f53bac85b2ec1dbb4d442c
https://pubmed.ncbi.nlm.nih.gov/1523869
https://pubmed.ncbi.nlm.nih.gov/1523869
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(2)
1. More than 60% of oral doses of 14C-1,2,4-trichlorobenzene (ca. 21 mg/kg) administered to rats were excreted in bile as S-trichlorophenyl-mercapturic acid pathway metabolites. 2. The biliary metabolites were ultimately excreted in urine mainly as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178f40297e98d6edb3f40c2beabef88a
https://pubmed.ncbi.nlm.nih.gov/1632109
https://pubmed.ncbi.nlm.nih.gov/1632109
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 17(1)
The toxic effects of the herbicide chlorthiamid (2,6-dichlorothiobenzamide) and its major environmental metabolite 2,6-dichlorobenzamide (DCBA) were examined in the nasal passages of C57Bl mice following single ip injections. Chlorthiamid (12.25, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c2618cc7f9b1ce92b454377ec8454e
https://pubmed.ncbi.nlm.nih.gov/1916084
https://pubmed.ncbi.nlm.nih.gov/1916084
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 21(2)
1. 14C-Methylthio-labelled 2-methylthio-4-ethylamino-6-tert-butylamino-sym-triazine (terbutryn), pentachlorothioanisole (PCTA), and 1,4-bis(methylthio)tetrachloro-benzene (bis-MTTCB) and their methylthio-oxidation congeners were reacted with glutathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c43c2c3ea7ac7ba072a23c7587ed4d
https://pubmed.ncbi.nlm.nih.gov/2058174
https://pubmed.ncbi.nlm.nih.gov/2058174
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 20(8)
1. The glutathione conjugate of 2-chloro-N-isopropyl[1-14C]acetanilide (14C-propachlor) was perfused through a calf kidney in situ; 23% of the dose was excreted in the perfused kidney urine as the cysteine conjugate, no mercapturic acid was detected.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdeacbd7fe7d560c79c60259411026f3
https://pubmed.ncbi.nlm.nih.gov/2219963
https://pubmed.ncbi.nlm.nih.gov/2219963
Biliary excretion and intestinal metabolism in the intermediary metabolism of pentachlorothioanisole
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 20(6)
1. Biliary metabolites from rats dosed with pentachlorothioanisole (PCTA) were characterized by fast atom bombardment mass spectrometry and electron impact mass spectrometry. 2. Most of the biliary metabolites from PCTA were mercapturic acid pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764e6978803d518840d18b323d33d353
https://pubmed.ncbi.nlm.nih.gov/2219954
https://pubmed.ncbi.nlm.nih.gov/2219954