Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jerome E Lee"'
Autor:
Joseph Russo, Jerome E Lee, Carolina M López, John Anderson, Thuy-Mi P Nguyen, Adam M Heck, Jeffrey Wilusz, Carol J Wilusz
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170680 (2017)
We previously identified several mRNAs encoding components of the secretory pathway, including signal recognition particle (SRP) subunit mRNAs, among transcripts associated with the RNA-binding protein CELF1. Through immunoprecipitation of RNAs cross
Externí odkaz:
https://doaj.org/article/e0a3b8c5c2f442b18b970ccd7093527c
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002901 (2012)
PARN is one of several deadenylase enzymes present in mammalian cells, and as such the contribution it makes to the regulation of gene expression is unclear. To address this, we performed global mRNA expression and half-life analysis on mouse myoblas
Externí odkaz:
https://doaj.org/article/f5baf467b8824d3aab936e3080144430
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11201 (2010)
Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay also play a major role in achieving rapid and massive changes in mRNA
Externí odkaz:
https://doaj.org/article/18c5097ac47f4ffc8dbe47e4c53f23c1
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
XPO5 mediates nuclear export of miRNA hairpin precursors (pre-miRNAs) through a RanGTP-dependent binding. Here the authors employ HITS-CLIP and biochemical analysis and show that XPO5 binds and promotes nuclear processing of clustered pri-miRNAs, wit
Externí odkaz:
https://doaj.org/article/e5599e5636e1449f8fedcdac30d97247
Autor:
John R. Anderson, Adam M. Heck, Jeffrey Wilusz, Joseph Russo, Thuy-mi P. Nguyen, Carolina M. López, Carol J. Wilusz, Jerome E. Lee
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170680 (2017)
PLoS ONE, Vol 12, Iss 1, p e0170680 (2017)
We previously identified several mRNAs encoding components of the secretory pathway, including signal recognition particle (SRP) subunit mRNAs, among transcripts associated with the RNA-binding protein CELF1. Through immunoprecipitation of RNAs cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3e3c35cc73b1b4f05cf4274a12fcba
https://pubmed.ncbi.nlm.nih.gov/28129347
https://pubmed.ncbi.nlm.nih.gov/28129347
Publikováno v:
Journal of Biological Chemistry. 283:22457-22463
Type I myotonic dystrophy (DM1) is caused by a triplet repeat expansion in the 3′-untranslated region (UTR) of the dystrophia myotonia protein kinase (DMPK) gene. Pathogenesis is closely linked with production of a toxic RNA from the mutant allele,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8a440f779550f37efe32ab9ce9624b5
https://doi.org/10.1074/jbc.m802803200
https://doi.org/10.1074/jbc.m802803200
Autor:
Jerome E. Lee, Rui Yi
Publikováno v:
Journal of Visualized Experiments.
MiRNA cloning and high-throughput sequencing, termed miR-Seq, stands alone as a transcriptome-wide approach to quantify miRNAs with single nucleotide resolution. This technique captures miRNAs by attaching 3’ and 5’ oligonucleotide adapters to mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313828547aae9e229d0b2d25268702b2
https://doi.org/10.3791/52095
https://doi.org/10.3791/52095
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002901 (2012)
PLoS Genetics
PLoS Genetics
PARN is one of several deadenylase enzymes present in mammalian cells, and as such the contribution it makes to the regulation of gene expression is unclear. To address this, we performed global mRNA expression and half-life analysis on mouse myoblas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94228f1f9a79d0267b5f0884fa7c05c5
http://europepmc.org/articles/PMC3431312?pdf=render
http://europepmc.org/articles/PMC3431312?pdf=render
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 6, p e11201 (2010)
PLoS ONE, Vol 5, Iss 6, p e11201 (2010)
Background: Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay also play a major role in achieving rapid and massive cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64601c135166ccd4c288c8b6d663d38
https://pubmed.ncbi.nlm.nih.gov/20574513
https://pubmed.ncbi.nlm.nih.gov/20574513
Autor:
Jeffrey Wilusz, Jerome E. Lee
Publikováno v:
Nature Structural & Molecular Biology. 17:675-676
Stringent post-transcriptional regulation of the amyloid precursor protein (APP) is critical for maintaining proper neurological function. In this issue, Lee et al. identify two RNA-binding proteins, FMRP and hnRNP C, that have opposite effects on AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::765e4163ab5f565403191fd2d248288e
https://doi.org/10.1038/nsmb0610-675
https://doi.org/10.1038/nsmb0610-675