Výsledky vyhledávání - "Jerome Bouquet"

Akademický článek

A diagnostic classifier for gene expression-based identification of early Lyme disease

Autor: Venice Servellita, Jerome Bouquet, Alison Rebman, Ting Yang, Erik Samayoa, Steve Miller, Mars Stone, Marion Lanteri, Michael Busch, Patrick Tang, Muhammad Morshed, Mark J. Soloski, John Aucott, Charles Y. Chiu

Publikováno v: Communications Medicine, Vol 2, Iss 1, Pp 1-10 (2022)

Servellita et al. develop a machine learning-based classifier to diagnose Lyme disease using gene expression data. The classifier achieves high sensitivity for early infections, even prior to positivity on antibody testing.

Externí odkaz: https://doaj.org/article/d2e81a56ad3c4ef39b1ee9abbd26c4b6

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Akademický článek

Microbial burden and viral exacerbations in a longitudinal multicenter COPD cohort

Autor: Jerome Bouquet, David E. Tabor, Jonathan S. Silver, Varsha Nair, Andrey Tovchigrechko, M. Pamela Griffin, Mark T. Esser, Bret R. Sellman, Hong Jin

Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-13 (2020)

Abstract Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by frequent exacerbation phenotypes independent of disease stage. Increasing evidence shows that the microbiota plays a role in disease progress

Externí odkaz: https://doaj.org/article/b40782eaebb849488cb62f533a32979e

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Akademický článek

Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection

Autor: Charles Y. Chiu, Claudia Sánchez-San Martín, Jerome Bouquet, Tony Li, Shigeo Yagi, Manasi Tamhankar, Vida L. Hodara, Laura M. Parodi, Sneha Somasekar, Guixia Yu, Luis D. Giavedoni, Suzette Tardif, Jean Patterson

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract A monkey model of Zika virus (ZIKV) infection is urgently needed to better understand transmission and pathogenesis, given its proven association with fetal brain defects in pregnant women and acute neurological illness. Here we experimental

Externí odkaz: https://doaj.org/article/294e2f7fb0544b8eaa8d9c5fdf5f2b6d

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Akademický článek

Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing.

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0212193 (2019)

Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a syndrome of unknown etiology characterized by profound fatigue exacerbated by physical activity, also known as post-exertional malaise (PEM). Previously, we did not detect evidence of

Externí odkaz: https://doaj.org/article/06f8e4da556145b5a18118393d62bea1

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Akademický článek

Longitudinal Transcriptome Analysis Reveals a Sustained Differential Gene Expression Signature in Patients Treated for Acute Lyme Disease

Autor: Jerome Bouquet, Mark J. Soloski, Andrea Swei, Chris Cheadle, Scot Federman, Jean-Noel Billaud, Alison W. Rebman, Beniwende Kabre, Richard Halpert, Meher Boorgula, John N. Aucott, Charles Y. Chiu

Publikováno v: mBio, Vol 7, Iss 1 (2016)

ABSTRACT Lyme disease is a tick-borne illness caused by the bacterium Borrelia burgdorferi, and approximately 10 to 20% of patients report persistent symptoms lasting months to years despite appropriate treatment with antibiotics. To gain insights in

Externí odkaz: https://doaj.org/article/eea8a68cb7b84d59b07ecdb79daebb47

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Safety, Tolerability and Pharmacokinetics of Half-Life Extended Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Monoclonal Antibodies AZD7442 (Tixagevimab-Cilgavimab) in Healthy Adults

Autor: Pablo Forte-Soto, Muna Albayaty, Dennis Brooks, Rosalinda H Arends, John Tillinghast, Anastasia A Aksyuk, Jerome Bouquet, Cecil Chen, Asfiha Gebre, Robert J Kubiak, Venkatesh Pilla Reddy, Seth Seegobin, Katie Streicher, Alison Templeton, Mark T Esser

Publikováno v: The Journal of Infectious Diseases. 227:1153-1163

Background AZD7442 is a combination of extended half-life, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)−specific neutralizing monoclonal antibodies (tixagevimab and cilgavimab). Methods This phase 1, first-in-human, randomized, doub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7914f5bd0b9ab66dcfa3888350bf6079
https://doi.org/10.1093/infdis/jiad014

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Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination

Autor: Ruipeng Mu, Yue Huang, Jerome Bouquet, Jiaqi Yuan, Robert J. Kubiak, Eric Ma, Sami Naser, William R. Mylott, Omnia A. Ismaiel, Aaron M. Wheeler, Rebecca Burkart, Diego F. Cortes, James Bruton, Rosalinda H. Arends, Meina Liang, Anton I. Rosenbaum

Publikováno v: Analytical chemistry. 94(43)

AZD7442 (tixagevimab [AZD8895]/cilgavimab [AZD1061]) is a monoclonal antibody (mAb) combination in development for the prevention and treatment of coronavirus disease 2019. Traditionally, bioanalysis of mAbs is performed using ligand binding assays (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d39f76485b797ba2a9ea0c6a6c34d28
https://pubmed.ncbi.nlm.nih.gov/36269894

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AZD7442 demonstrates prophylactic and therapeutic efficacy in non-human primates and extended half-life in humans

Despite the success of SARS-CoV-2 vaccines, there remains a need for more prevention and treatment options for individuals remaining at risk of COVID-19. Monoclonal antibodies (mAbs) against the viral spike protein have potential to both prevent and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9a7012b82f9d3d04b1fca881d83af33
https://doi.org/10.1101/2021.08.30.21262666

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Early changes in the circulating T cells are associated with clinical outcomes after PD-L1 blockade by durvalumab in advanced NSCLC patients

Autor: Elliot Naidus, Lawrence Fong, David Y. Oh, Nathan Standifer, Jerome Bouquet, Timothy Looney, Li Zhang, Hai Yang

Publikováno v: Cancer immunology, immunotherapy : CII, vol 70, iss 7
Cancer Immunology, Immunotherapy

Immune checkpoint inhibitors (ICI) are designed to activate exhausted tumor-reactive T cells thereby leading to tumor regression. Durvalumab, an ICI that binds to the programmed death ligand-1 (PD-L1) molecule, is approved as a consolidation therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81755443fe7b823829672ac3b3048c5d
https://escholarship.org/uc/item/53t0g7b0

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Microbial burden and viral exacerbations in a longitudinal multicenter COPD cohort

Autor: M. Pamela Griffin, Jerome Bouquet, Varsha Nair, Andrey Tovchigrechko, David E. Tabor, Mark T. Esser, Hong Jin, Bret R. Sellman, Jonathan Silver

Publikováno v: Respiratory research, 21:77
Respiratory Research, Vol 21, Iss 1, Pp 1-13 (2020)
Respiratory Research

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by frequent exacerbation phenotypes independent of disease stage. Increasing evidence shows that the microbiota plays a role in disease progression and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a70b534ffc668a4d382eea1b15b336
https://repository.publisso.de/resource/frl:6423645

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