Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Jerome Bill"'
Autor:
Sobhana Alekhya Sripada, Wenning Chu, Taufika Islam Williams, Matthew A. Teten, Brian J. Mosley, Ruben G. Carbonell, Abraham M. Lenhoff, Steven M. Cramer, Jerome Bill, Yinges Yigzaw, David J. Roush, Stefano Menegatti
Publikováno v:
Biotechnology and Bioengineering. 119:1873-1889
The growth of advanced analytics in manufacturing monoclonal antibodies (mAbs) has highlighted the challenges associated with the clearance of host cell proteins (HCPs). Of special concern is the removal of "persistent" HCPs, including immunogenic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7635790d7340f8d2099455bdb13d469
https://doi.org/10.1002/bit.28096
https://doi.org/10.1002/bit.28096
Autor:
Young Hoon Oh, Matthew L. Becker, Kerri M. Mendola, Leila H. Choe, Lie Min, Kelvin H. Lee, Yinges Yigzaw, Alexander Seay, Jerome Bill, Xuanwen Li, David J. Roush, Steven M. Cramer, Stefano Menegatti, Abraham M. Lenhoff
Publikováno v:
Biotechnology and bioengineering.
In the production of biopharmaceuticals such as monoclonal antibodies (mAbs) and vaccines, the residual amounts of host-cell proteins (HCPs) are among the critical quality attributes. In addition to overall HCP levels, individual HCPs may elude purif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9628e711fe90e567952f681011b1457e
https://pubmed.ncbi.nlm.nih.gov/36585356
https://pubmed.ncbi.nlm.nih.gov/36585356
Students in two classes in the fall of 2004 making extensive use of online courseware were logged as they visited over 500 different “learning pages” which varied in length and in difficulty. We computed the time spent on each page by each studen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b8a149af24ec5aacb88d0137552fe6
Publikováno v:
Biotechnology and Applied Biochemistry
The present study examined the overloading of ion-exchange membrane adsorbers, a form of frontal chromatography, as the final purification step in the production of mAbs (monoclonal antibodies) produced from CHO (Chinese-hamster ovary) cells. Prefere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd491fc46942a73415d1e95c66b74f97
http://europepmc.org/articles/PMC2891000
http://europepmc.org/articles/PMC2891000
Autor:
Brian M. Freed, Douglas G. Mack, Jerome Bill, Andrew P. Fontenot, Allison K. Martin, Brian L. Kotzin, Fenneke G. Joslin, Michael T. Falta, Lisa A. Maier, Andrew K. Sullivan
Publikováno v:
The Journal of Immunology. 175:7029-7037
Chronic beryllium disease (CBD) is characterized by a CD4+ T cell alveolitis and granulomatous inflammation in the lung. Genetic susceptibility to this disease has been linked with HLA-DP alleles, particularly those possessing a glutamic acid at posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b072c370c628a1ff1b49c35b824e95e5
https://doi.org/10.4049/jimmunol.175.10.7029
https://doi.org/10.4049/jimmunol.175.10.7029
Autor:
Satyan Pai, Jerome Bill, Charity Bechtel, Jun Liu, Brooke Ellen Thayer, Arick Brown, Daniel Mcdonald, Hui Liu, Asha Nandini Radhamohan, Christopher F. Dowd, Stefan T. Yohe, Ryan S. Renslow
Publikováno v:
Biotechnology and bioengineering. 106(4)
Pre-filtration using ion exchange membrane adsorbers can improve parvovirus filter throughput of monoclonal antibodies (mAbs). The membranes work by binding trace foulants, and although some antibody product also binds, yields > or =99% are easily ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a3a8cbfb94565eabcb0b78bf0b0116
https://pubmed.ncbi.nlm.nih.gov/20229510
https://pubmed.ncbi.nlm.nih.gov/20229510
Publikováno v:
Biotechnology and bioengineering. 92(4)
Microbial protein display technologies have enabled directed molecular evolution of binding and stability properties in numerous protein systems. In particular, dramatic improvements to antibody binding affinity and kinetics have been accomplished us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4b44d514882ddecd22ef44060a1014
https://pubmed.ncbi.nlm.nih.gov/16155952
https://pubmed.ncbi.nlm.nih.gov/16155952
Autor:
Christina L. Roark, John W. Kappler, Andrew P. Fontenot, Brian L. Kotzin, Michael T. Falta, Jerome Bill, Philippa Marrack, Edward F. Rosloniec, Frances Crawford
Publikováno v:
Arthritis and rheumatism. 52(6)
Objective Although studies have suggested that human cartilage (HC) gp-39 may be an antigen recognized by autoreactive CD4+ T cells in rheumatoid arthritis, we previously failed to identify specific CD4+ T cells in patients' synovial fluid or blood u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f557ddc445c25e45debe54fbbd6dc19
https://pubmed.ncbi.nlm.nih.gov/15934080
https://pubmed.ncbi.nlm.nih.gov/15934080
HIV-infected patients on highly active antiretroviral therapy (HAART) have persistently decreased cytomegalovirus (CMV)-specific proliferative responses [lymphocyte proliferation assay (LPA)] in spite of increases in CD4+ T cell counts. Here we demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a278e47114c711a24f749439fca8d4