Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jerome B. Zisfein"'
Autor:
Jerome B. Zisfein, Michael N. Margolies, Gary R. Matsueda, G. M. Wildey, C J Homcy, Alan J. Fischman, Robert M. Graham
Publikováno v:
Peptides. 9:1275-1283
An immunological approach was used to investigate the specificity of protease cleavage sites on proANF. Cleavage of 35S-cysteine biosynthetically-labeled proANF by whole serum, thrombin and kallikrein was examined. Reaction products were immunoprecip
Publikováno v:
Biochemical and Biophysical Research Communications. 140:151-159
Cultured cardiac myocytes provide a useful system for investigating ANF biosynthesis and regulation. It has previously been demonstrated that the predominant form of ANF stored in and released from this myocyte model is the 17kD prohormone, proANF. W
Autor:
Gary R. Matsueda, G. M. Wildey, C J Homcy, Alan J. Fischman, J. T. Fallon, G. Seipke, Jerome B. Zisfein, G. Preibisch, Robert M. Graham
Publikováno v:
Endocrinology. 123:2054-2061
Atrial natriuretic factor (ANF) is stored in atrial myocytes as a 15-17K prohormone, but circulates in plasma as a 3K, carboxy (C)-terminal fragment of the prohormone. The tissue location at which the cleavage of pro-ANF to its hormonal form occurs i
Publikováno v:
Life Sciences. 41:1953-1959
Atrial natriuretic factor (ANF) is stored in atrial cardiocytes as the 126 amino acid polypeptide, proANF, which is later cleaved to the 24–28 amino acid carboxyterminal peptides, the major circulating forms. Earlier studies have demonstrated that
Autor:
Stephen V. Dreskin, Gary M. Wildey, Charles J. Homcy, Robert M. Graham, Jerome B. Zisfein, Alan J. Fischman
Publikováno v:
Biochemistry. 26:8690-8697
Atrial natriuretic factor (ANF) is synthesized and stored in atrial cardiocytes as a 17-kilodalton (kDa), 126 amino acid polypeptide, proANF, but circulates as smaller, 24 and 28 amino acid peptide fragments of the carboxy terminus of proANF. This re
Autor:
Michael N. Margolies, Jerome B. Zisfein, Christine E. Seidman, Robert M. Graham, Charles J. Homcy, John T. Fallon, Jonathan G. Seidman, James A. Scott, Gary R. Matsueda, Kenneth D. Bloch
Publikováno v:
Science (New York, N.Y.). 230(4730)
Rat atrial natriuretic factor (ANF) is translated as a 152-amino acid precursor preproANF. PreproANF is converted to the 126-amino acid proANF, the storage form of ANF in the atria. ANF isolated from the blood is approximately 25 amino acids long. It
Autor:
Jonathan G. Seidman, John T. Fallon, Christine E. Seidman, Robert M. Graham, Charles J. Homcy, Gary R. Matsueda, Jerome B. Zisfein, Kenneth D. Bloch
Publikováno v:
Journal of molecular and cellular cardiology. 18(9)
Atrial natriuretic factor (ANF) is a polypeptide that has been isolated from mammalian atrial tissue with potent natriuretic, diuretic and spasmolytic properties. Details of its biosynthesis, cleavage, storage and release are not yet fully defined. U
Autor:
Kenneth D. Bloch, Robert M. Graham, A D Duby, Edgar Haber, Jerome B. Zisfein, Jonathan G. Seidman, John A. Smith, Christine E. Seidman, E Choi, Charles J. Homcy
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 7(3 Pt 2)
The molecular biology of human atrial natriuretic factor was studied. A cloned rat cDNA probe was used to analyze tissue for the synthesis of atrial natriuretic factor, and the human gene was identified and sequenced. Nucleotide sequence comparison o
Autor:
C J Homcy, Michael N. Margolies, Kenneth D. Bloch, Jerome B. Zisfein, Robert M. Graham, Jonathan G. Seidman
Publikováno v:
The American journal of physiology. 252(1 Pt 1)
Proatrial natriuretic factor (proANF), the 126-amino acid precursor of ANF, is the major storage form in mammalian atria. In contrast, two ANF peptides containing the 28- and 24-carboxyterminal residues of proANF have been isolated from rat plasma. W
Publikováno v:
New England Journal of Medicine. 313:1484-1485