Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Jerome A. Zack"'
Autor:
Jocelyn T. Kim, Tian-Hao Zhang, Camille Carmona, Bryanna Lee, Christopher S. Seet, Matthew Kostelny, Nisarg Shah, Hongying Chen, Kylie Farrell, Mohamed S. A. Soliman, Melanie Dimapasoc, Michelle Sinani, Kenia Yazmin Reyna Blanco, David Bojorquez, Hong Jiang, Yuan Shi, Yushen Du, Natalia L. Komarova, Dominik Wodarz, Paul A. Wender, Matthew D. Marsden, Ren Sun, Jerome A. Zack
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, Kim et al. describe a new kick and kill strategy utilizing a single administration of a protein kinase C modulator and latency reversing agent in combination with injections of allogeneic peripheral blood natural killer cells diminishes the HIV
Externí odkaz:
https://doaj.org/article/7b9b98b368d54eccabea67b1cb3df389
Autor:
Jocelyn T. Kim, Jerome A. Zack
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
NK cells are an important subset of innate immune effectors with antiviral activity. However, NK cell development and immune responses in different tissues during acute and chronic HIV infection in vivo have been difficult to study due to the impaire
Externí odkaz:
https://doaj.org/article/3b383a5a35454641b4aaa2b8ad355bba
Publikováno v:
Microorganisms, Vol 11, Iss 8, p 1984 (2023)
Human immunodeficiency virus (HIV) has infected millions of people worldwide and continues to be a major global health problem. Scientists required a small animal model to study HIV pathogenesis and immune responses. To this end, humanized mice were
Externí odkaz:
https://doaj.org/article/7f62f6664655406d9e17bfa9698c6b64
Autor:
Clayton Hardman, Stephen Ho, Akira Shimizu, Quang Luu-Nguyen, Jack L. Sloane, Mohamed S. A. Soliman, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Bryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cel
Externí odkaz:
https://doaj.org/article/ebe37911de374c93a36c1ee604f378a0
Autor:
Isaac M. Barber-Axthelm, Valerie Barber-Axthelm, Kai Yin Sze, Anjie Zhen, Gajendra W. Suryawanshi, Irvin S.Y. Chen, Jerome A. Zack, Scott G. Kitchen, Hans-Peter Kiem, Christopher W. Peterson
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with CCR5– donor cells is the only treatment known to cure HIV-1 in patients with underlying malignancy. This is likely due to a donor cell–mediated graft-versus-host effect targeting
Externí odkaz:
https://doaj.org/article/113afdd7adba44389c9032150f25a7e3
Autor:
Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 3, Pp 100037- (2020)
Summary: “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells. We have previously reported that induc
Externí odkaz:
https://doaj.org/article/844b2284d4654ae7b526e217e79fb151
Autor:
Roni A. Hazim, Saravanan Karumbayaram, Mei Jiang, Anupama Dimashkie, Vanda S. Lopes, Douran Li, Barry L. Burgess, Preethi Vijayaraj, Jackelyn A. Alva-Ornelas, Jerome A. Zack, Donald B. Kohn, Brigitte N. Gomperts, April D. Pyle, William E. Lowry, David S. Williams
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-17 (2017)
Abstract Background Dysfunction of the retinal pigment epithelium (RPE) is implicated in numerous forms of retinal degeneration. The readily accessible environment of the eye makes it particularly suitable for the transplantation of RPE cells, which
Externí odkaz:
https://doaj.org/article/445af3da774d42bc8f820fa516dc9a9e
Autor:
Roni A. Hazim, Saravanan Karumbayaram, Mei Jiang, Anupama Dimashkie, Vanda S. Lopes, Douran Li, Barry L. Burgess, Preethi Vijayaraj, Jackelyn A. Alva-Ornelas, Jerome A. Zack, Donald B. Kohn, Brigitte N. Gomperts, April D. Pyle, William E. Lowry, David S. Williams
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-2 (2019)
The original article [1] contains an error in the legend of Fig 5 whereby the descriptions for panels 5d and 5e are incorrect; as such, the corrected legend can be viewed below with its respective figure images.
Externí odkaz:
https://doaj.org/article/a8598372eeb04d039f8f3dfb5d3e70ec
Publikováno v:
Stem Cells International, Vol 2011 (2011)
Gene therapy for individuals infected with HIV has the potential to provide a once-only treatment that will act to reduce viral load, preserve the immune system, and mitigate cumulative toxicities associated with highly active antiretroviral therapy
Externí odkaz:
https://doaj.org/article/eaec1152634542a8af127427e692e94d
Autor:
Jose A. Moran, Alok Ranjan, Rami Hourani, Jocelyn T. Kim, Paul A. Wender, Jerome A. Zack, Matthew D. Marsden
Publikováno v:
Virology. 581:8-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4137b4194e997f92cef3e1690347f184
https://doi.org/10.1016/j.virol.2023.02.009
https://doi.org/10.1016/j.virol.2023.02.009