Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jerome A Staal"'
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22040 (2011)
BACKGROUND: Organotypic brain slice culturing techniques are extensively used in a wide range of experimental procedures and are particularly useful in providing mechanistic insights into neurological disorders or injury. The cellular and morphologic
Externí odkaz:
https://doaj.org/article/8104c38fae7a419a84abc05c30faec6a
Autor:
Kristy J. Brown, Heather Gordish-Dressman, Mojca Stampar, Ling San Lau, Samuel Rivero-Hinojosa, Jerome A. Staal, Stefan M. Pfister, Michael D. Taylor, Brian R. Rood, Huizhen Zhang, Paul A. Northcott
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-19 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Genomic characterization has begun to redefine diagnostic classifications of cancers. However, it remains a challenge to infer disease phenotypes from genomic alterations alone. To help realize the promise of genomics, we have performed a quantitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94720794c9b0d701859aa9e24ae60fc0
http://link.springer.com/article/10.1186/s40478-018-0548-7
http://link.springer.com/article/10.1186/s40478-018-0548-7
Autor:
Ling San Lau, Andrew R. Hallahan, Kristy J. Brown, Jerome A. Staal, Stefan M. Pfister, Yoon Jae Cho, Huizhen Zhang, Paul A. Northcott, Roger J. Packer, Wendy J. Ingram, Robert J. Wechsler-Reya, Michael D. Taylor, Jessica M. Rusert, Brian R. Rood
Publikováno v:
Oncotarget
ResearcherID
ResearcherID
Genomic characterization of medulloblastoma has improved molecular risk classification but struggles to define functional biological processes, particularly for the most aggressive subgroups. We present here a novel proteomic approach to this problem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e270369332310e60130398a79e05a
https://doi.org/10.18632/oncotarget.3927
https://doi.org/10.18632/oncotarget.3927
Autor:
Ling San Lau, Brian R. Rood, Samuel Rivero-Hinojosa, Kristy J. Brown, Javad Nazarian, Heather Gordish-Dressman, Yetrib Hathout, Huizhen Zhang, Jerome A. Staal, Mojca Stampar
The genomic characterization of medulloblastoma at the level of the chromosome, epigenome and transcriptome has radically redefined diagnostic classifications and reoriented disease definitions toward a biological underpinning. However, it still rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b813bafa17d76f091b90904bebff11
https://europepmc.org/articles/PMC5475134/
https://europepmc.org/articles/PMC5475134/
Autor:
Olivier Bibari, Yao Liu, James C. Vickers, Jerome A. Staal, Matthew T. K. Kirkcaldie, Stan Mitew, Anna E. King, Tracey C. Dickson, Alison J. Canty
Publikováno v:
Journal of Comparative Neurology. 521:1817-1827
The neurofilament light (NFL) subunit is considered as an obligate subunit polymer for neuronal intermediate filaments comprising the neurofilament (NF) triplet proteins. We examined cytoskeletal protein levels in the cerebral cortex of NFL knockout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9a2609e977ea4d37cf3db2b5b42f431
https://doi.org/10.1002/cne.23261
https://doi.org/10.1002/cne.23261
Autor:
Jerome A. Staal, James C. Vickers
Publikováno v:
Journal of Neurotrauma. 28:841-847
Diffuse axonal injury (DAI) is an evolving axonopathy commonly characterized clinically as widespread damage to the white matter tracts. In recent electrophysiological studies, researchers have proposed that myelinated and unmyelinated axons differ i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baddd40c6592a4721895efe94b0b6383
https://doi.org/10.1089/neu.2010.1658
https://doi.org/10.1089/neu.2010.1658
Publikováno v:
Journal of Neurochemistry. 112:1147-1155
Acute axonal shear and stretch in the brain induces an evolving form of axonopathy and is a major cause of ongoing motor, cognitive and emotional dysfunction. We have utilized an in vitro model of mild axon bundle stretch injury, in cultured primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdcdf3d0a7395afee45aa7add91260c
https://doi.org/10.1111/j.1471-4159.2009.06531.x
https://doi.org/10.1111/j.1471-4159.2009.06531.x
Autor:
Adele Woodhouse, Catherine A. Blizzard, JA Chuckowree, Matthew T. K. Kirkcaldie, Ruth E. Musgrove, Tracey C. Dickson, Anna E. King, Stanislaw Mitew, Yao Liu, Graeme H. McCormack, Olivier Bibari, James C. Vickers, Jerome A. Staal
Publikováno v:
Brain Research Bulletin. 80:217-223
There has been growing interest in the axon as the initial focus of pathological change in a number of neurodegenerative diseases of the central nervous system. This review concentrates on three major neurodegenerative conditions--amyotrophic lateral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230b5e8f154b0776a5a80f901e36f7b2
https://doi.org/10.1016/j.brainresbull.2009.08.004
https://doi.org/10.1016/j.brainresbull.2009.08.004
Publikováno v:
Macquarie University
The ubiquitin proteasome system (UPS) plays a vital role in the regulation of protein degradation. Ubiquitination of proteins has been implicated in the pathological cascade associated with neuronal degeneration in both neurodegenerative disease and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359982ddf74fb4990882429bb89ef8ce
https://doi.org/10.1089/neu.2008.0669
https://doi.org/10.1089/neu.2008.0669
Publikováno v:
NeuroReport. 18:283-288
Live-imaging brain slice techniques were utilized to study the acute changes in transected adult mammalian neocortical neuronal processes. Transected distal axons, but not axon segments directly emerging from the cell body or dendrites, undergo rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2cdd0e8e07317c81b4a2aef82d80d5
https://doi.org/10.1097/wnr.0b013e3280143cdb
https://doi.org/10.1097/wnr.0b013e3280143cdb