Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Jerold G. Woodward"'
Autor:
Siva K. Gandhapudi, Hua Shi, Martin R. Ward, John Peyton Bush, Margarita Avdiushko, Karuna Sundarapandiyan, Lauren V. Wood, Mania Dorrani, Afsheen Fatima, Joe Dervan, Frank Bedu-Addo, Greg Conn, Ted M. Ross, Jerold G. Woodward
Publikováno v:
Viruses, Vol 15, Iss 2, p 432 (2023)
Adjuvants are essential components of subunit vaccines added to enhance immune responses to antigens through immunomodulation. Very few adjuvants have been approved for human use by regulatory agencies due to safety concerns. Current subunit vaccine
Externí odkaz:
https://doaj.org/article/34c62344fca4487da98e87adc6efc885
Autor:
Thomas R. Henson, Katherine A. Richards, Siva K. Gandhapudi, Jerold G. Woodward, Andrea J. Sant
Publikováno v:
Viruses, Vol 15, Iss 2, p 538 (2023)
It is clear that new approaches are needed to promote broadly protective immunity to viral pathogens, particularly those that are prone to mutation and escape from antibody-mediated immunity. Prototypic pathogens of this type are influenza and SARS-C
Externí odkaz:
https://doaj.org/article/9349ee20a25f415a9021e013f3fd4160
Autor:
Siva K Gandhapudi, Karuna Sundarapandiyan, Martin Ward, Afsheen Fatima, Mania Dorrani, Mary Banoub, Joe Dervan, Lauren Wood, Greg Conn, Jerold G Woodward
Publikováno v:
Cancer Immunology Research. 10:B24-B24
The enantiomeric cationic lipid R-DOTAP nanoparticle platform (Versamune®) was reported (Gandhapudi et. al. 2019, J. Immunol.) to promote cross presentation of multi-epitope human papilloma virus (HPV) antigens and upregulation of Type I interferons
Publikováno v:
HIV/AIDS: Research and Palliative Care, Vol 2009, Iss Default, Pp 1-11 (2009)
Weili Yan1, Anekant Jain1, Ronan O’Carra2, Jerold G Woodward3, Wenxue Li4, Guanhan Li4, Avindra Nath4, Russell J Mumper11Division of Molecular Pharmaceutics and the Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, Uni
Externí odkaz:
https://doaj.org/article/7706c45d7add429e9ae0378dccd0a4f7
Autor:
Frank K. Bedu-Addo, Siva K. Gandhapudi, Martin Ward, John Peyton C Bush, Greg Conn, Jerold G. Woodward
Publikováno v:
J Immunol
Certain types of cationic lipids have shown promise in cancer immunotherapy, but their mechanism of action is poorly understood. In this study, we describe the properties of an immunotherapeutic consisting of the pure cationic lipid enantiomer R-1,2-
Autor:
Stephanie E. Reedy, Mizuki Tateno, Thomas R. Gawriluk, Barbara J. Stone, Sarah Srodulski, Joseph Chappell, Chase Kempinski, Thomas M. Chambers, Jerold G. Woodward
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
The triterpene oil squalene is an essential component of nanoemulsion vaccine adjuvants. It is most notably in the MF59 adjuvant, a component in some seasonal influenza vaccines, in stockpiled, emulsion-based adjuvanted pandemic influenza vaccines, a
Autor:
Bridgette Baron, Elizabeth M. Johnson, Ashley J. Wilhelm, Damian Maseda, Leslie J. Crofford, Martin R. Ward, Fumiaki Kojima, Jerold G. Woodward, Lindsay E. Nyhoff, David D. Brand
Publikováno v:
The Journal of Immunology. 200:725-736
The integration of inflammatory signals is paramount in controlling the intensity and duration of immune responses. Eicosanoids, particularly PGE2, are critical molecules in the initiation and resolution of inflammation and in the transition from inn
Autor:
Jeremy P. Wood, Meenakshi Banerjee, Jamie Sturgill, Beth A. Garvy, Martha M.S. Sim, Marietta Barton-Baxter, Melissa Hollifield, Xian Li, Gail Sievert, Jerold G. Woodward, Hammodah Alfar, James Zachary Porterfield, Alice Thornton, Sidney W. Whiteheart, Kenneth S. Campbell
Publikováno v:
Blood
Background:A hypercoagulable state has been consistently reported in patients with severe Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), characterized by elevated D-dimer, prolonged PT, an
Autor:
Ellen Reusch, Jing Wei, Lauren Corum, Jerold G. Woodward, Mahesh Kudrimoti, Subbarao Bondada, Ronald C. McGarry, Donald A. Cohen, Val R. Adams, John L. Villano, Aasems Jacob, Rachael M. Morgan, Zin W. Myint, Alexander Kreimer, Susanne M. Arnold, Jianrong Wu, William H. St. Clair
Publikováno v:
Journal of Clinical Oncology. 39:2628-2628
2628 Background: Preclinical models demonstrate that combined RT with immune checkpoint inhibitor (ICI) results in specific CD8+ T-cell phenotype associated with a tumor-reactive population resulting in significant tumor response. Sequential treatmen
Autor:
Siva K. Gandhapudi, Lauren Virginia Wood, Jerold G. Woodward, Gregory Conn, Frank K. Bedu-Addo, Karuna Sundarapandiyan
Publikováno v:
Journal of Clinical Oncology. 38:e15211-e15211
e15211 Background: Immunotherapy approaches are limited in their ability to induce antigen-specific CD8+ T cells in vivo able to recognize and kill tumor cells. We developed a novel immunotherapy approach using enantiomerically pure, R-DOTAP cationic