Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Jerold E Rehg"'
Autor:
Priya Mittal, Jacquelyn A. Myers, Raymond D. Carter, Sandi Radko-Juettner, Hayden A. Malone, Wojciech Rosikiewicz, Alexis N. Robertson, Zhexin Zhu, Ishwarya V. Narayanan, Baranda S. Hansen, Meadow Parrish, Natarajan V. Bhanu, Robert J. Mobley, Jerold E. Rehg, Beisi Xu, Yiannis Drosos, Shondra M. Pruett-Miller, Mats Ljungman, Benjamin A. Garcia, Gang Wu, Janet F. Partridge, Charles W. M. Roberts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations drive cancer, we contributed ten rhabdoid tumor (RT) cell lines muta
Externí odkaz:
https://doaj.org/article/fb1fbd9e73e346ad922fc3783cc2f771
Autor:
Stephanie A Shumar, Paolo Fagone, Adolfo Alfonso-Pecchio, John T Gray, Jerold E Rehg, Suzanne Jackowski, Roberta Leonardi
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130013 (2015)
Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms
Externí odkaz:
https://doaj.org/article/015a4f62aa274b6580709bbc9c4775a8
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40871 (2012)
Pantothenate kinase (PanK) phosphorylates pantothenic acid (vitamin B(5)) and controls the overall rate of coenzyme A (CoA) biosynthesis. Pank1 gene deletion in mice results in a metabolic phenotype where fatty acid oxidation and gluconeogenesis are
Externí odkaz:
https://doaj.org/article/f2a5c2a86e3544c98b022770c4c6d0b4
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41609 (2012)
H1N1 viruses in which all gene segments are of avian origin are the most frequent cause of influenza pandemics in humans; therefore, we examined the disease-causing potential of 31 avian H1N1 isolates of American lineage in DBA/2J mice. Thirty of 31
Externí odkaz:
https://doaj.org/article/d9abf39951dc4232aa9418eed2ed5468
Autor:
Subrata Barman, Petr S Krylov, Thomas P Fabrizio, John Franks, Jasmine C Turner, Patrick Seiler, David Wang, Jerold E Rehg, Gene A Erickson, Marie Gramer, Robert G Webster, Richard J Webby
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002791 (2012)
North American triple reassortant swine (TRS) influenza A viruses have caused sporadic human infections since 2005, but human-to-human transmission has not been documented. These viruses have six gene segments (PB2, PB1, PA, HA, NP, and NS) closely r
Externí odkaz:
https://doaj.org/article/86fb338e9ac8423797ebc87cdf8157c6
Autor:
Tal Teitz, Jennifer J Stanke, Sara Federico, Cori L Bradley, Rachel Brennan, Jiakun Zhang, Melissa D Johnson, Jan Sedlacik, Madoka Inoue, Ziwei M Zhang, Sharon Frase, Jerold E Rehg, Claudia M Hillenbrand, David Finkelstein, Christopher Calabrese, Michael A Dyer, Jill M Lahti
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19133 (2011)
Preclinical models of pediatric cancers are essential for testing new chemotherapeutic combinations for clinical trials. The most widely used genetic model for preclinical testing of neuroblastoma is the TH-MYCN mouse. This neuroblastoma-prone mouse
Externí odkaz:
https://doaj.org/article/52bc2dee759649ba8278b5a9519f310e
Autor:
Sean P Garrison, Justin A Thornton, Hans Häcker, Richard Webby, Jerold E Rehg, Evan Parganas, Gerard P Zambetti, Elaine I Tuomanen
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001240 (2010)
Disruption of p53/Puma-mediated apoptosis protects against lethality due to DNA damage. Here we demonstrate the unexpected requirement of the pro-apoptotic p53-target gene Puma to mount a successful innate immune response to bacterial sepsis. Puma⁻
Externí odkaz:
https://doaj.org/article/7b627385eab54f24b899f8c3faeb10c6
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11107 (2010)
Coenzyme A (CoA) biosynthesis is regulated by the pantothenate kinases (PanK), of which there are four active isoforms. The PanK1 isoform is selectively expressed in liver and accounted for 40% of the total PanK activity in this organ. CoA synthesis
Externí odkaz:
https://doaj.org/article/16f068bd891c4086b5facc647747de3e
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000933 (2010)
The acquisition of neuraminidase (NA) inhibitor resistance by H5N1 influenza viruses has serious clinical implications, as this class of drugs can be an essential component of pandemic control measures. The continuous evolution of the highly pathogen
Externí odkaz:
https://doaj.org/article/cf5ad1e36b22499bafec046e136fecb5
Autor:
Madeline B. Searcy, Randolph K. Larsen, Bradley T. Stevens, Yang Zhang, Hongjian Jin, Catherine J. Drummond, Casey G. Langdon, Katherine E. Gadek, Kyna Vuong, Kristin B. Reed, Matthew R. Garcia, Beisi Xu, Darden W. Kimbrough, Grace E. Adkins, Nadhir Djekidel, Shaina N. Porter, Patrick A. Schreiner, Shondra M. Pruett-Miller, Brian J. Abraham, Jerold E. Rehg, Mark E. Hatley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1 (P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS histologically resembles developing muscle yet occurs throughout the
Externí odkaz:
https://doaj.org/article/af11c11b372b412d83edd57dfaac71cf