Výsledky vyhledávání - "Jerold E, Rehg"

Akademický článek

PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations drive cancer, we contributed ten rhabdoid tumor (RT) cell lines muta

Externí odkaz: https://doaj.org/article/fb1fbd9e73e346ad922fc3783cc2f771

Zobrazit plný text záznamu

Akademický článek

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1 (P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS histologically resembles developing muscle yet occurs throughout the

Externí odkaz: https://doaj.org/article/af11c11b372b412d83edd57dfaac71cf

Zobrazit plný text záznamu

Akademický článek

Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)

Abstract A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that re

Externí odkaz: https://doaj.org/article/518df2bf603d4dbaa5922a65b63e4a51

Zobrazit plný text záznamu

Akademický článek

Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity

Autor: Casey G. Langdon, Katherine E. Gadek, Matthew R. Garcia, Myron K. Evans, Kristin B. Reed, Madeline Bush, Jason A. Hanna, Catherine J. Drummond, Matthew C. Maguire, Patrick J. Leavey, David Finkelstein, Hongjian Jin, Patrick A. Schreiner, Jerold E. Rehg, Mark E. Hatley

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axi

Externí odkaz: https://doaj.org/article/0413e8410b0248ed86492edc2f4f4634

Zobrazit plný text záznamu

Akademický článek

Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

The progress in pre-clinical drug discovery for Wilms tumor (WT) is limited by a lack of disease models. Here, the authors develop 45 heterotopic WT patient-derived xenografts including several anaplastic models that recapitulate the biological heter

Externí odkaz: https://doaj.org/article/db96314ad7db4fb39fc7295bd2b1e60c

Zobrazit plný text záznamu

Akademický článek

Large 1p36 Deletions Affecting Arid1a Locus Facilitate Mycn-Driven Oncogenesis in Neuroblastoma

Autor: Jesus García-López, Kirby Wallace, Joel H. Otero, Rachelle Olsen, Yong-dong Wang, David Finkelstein, Brian L. Gudenas, Jerold E. Rehg, Paul Northcott, Andrew M. Davidoff, Kevin W. Freeman

Publikováno v: Cell Reports, Vol 30, Iss 2, Pp 454-464.e5 (2020)

Summary: Loss of heterozygosity (LOH) at 1p36 occurs in multiple cancers, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions tightly correlate with markers of tumor aggressiveness in NBL. Although distal 1p36 losses associate with s

Externí odkaz: https://doaj.org/article/239e06a48f6c4cdb89b1b7a993ab5041

Zobrazit plný text záznamu

Akademický článek

Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan

Autor: Atanaska Marinova-Petkova, John Franks, Sangay Tenzin, Narapati Dahal, Kinzang Dukpa, Jambay Dorjee, Mohammed M. Feeroz, Jerold E. Rehg, Subrata Barman, Scott Krauss, Pamela McKenzie, Richard Webby, Robert G. Webster

Publikováno v: Emerging Infectious Diseases, Vol 22, Iss 12, Pp 2137-2141 (2016)

Highly pathogenic avian influenza A(H5N1), clade 2.3.2.1a, with an H9-like polymerase basic protein 1 gene, isolated in Bhutan in 2012, replicated faster in vitro than its H5N1 parental genotype and was transmitted more efficiently in a chicken model

Externí odkaz: https://doaj.org/article/5705082963e64d2483855c6e760b89f6

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání