Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Jerold A Last"'
Autor:
Laura A Cagle, Lisa M Franzi, Angela L Linderholm, Jerold A Last, Jason Y Adams, Richart W Harper, Nicholas J Kenyon
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187419 (2017)
Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prev
Externí odkaz:
https://doaj.org/article/9a19195bec9548dc97cb380c8897b421
Autor:
Noelia Morel, Gabriel Lassabe, Susana Elola, Mauricio Bondad, Silvia Herrera, Carlos Marí, Jerold A Last, Oscar Jensen, Gualberto Gonzalez-Sapienza
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 1, p e1967 (2013)
Cystic echinococcosis is still a major concern in South America. While some regions show advances in the control of the disease, others have among the highest incidence in the world. To reverse this situation the Pan American Health Organization (PAH
Externí odkaz:
https://doaj.org/article/a43f2281f4c14eb99cfc2b95512f35a6
Autor:
David C. Yang, Ji‐Min Li, Jihao Xu, Justin Oldham, Sem H. Phan, Jerold A. Last, Reen Wu, Ching‐Hsien Chen
Publikováno v:
FASEB J
Targeting activated fibroblasts, including myofibroblast differentiation, has emerged as a key therapeutic strategy in patients with idiopathic pulmonary fibrosis (IPF). However, there is no available therapy capable of selectively eradicating myofib
Autor:
Jennifer M. Bratt, Keisha Williams, Michelle F. Rabowsky, Michael S. Last, Lisa M. Franzi, Jerold A. Last, Nicholas J. Kenyon
Publikováno v:
Mediators of Inflammation, Vol 2010 (2010)
Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflamma
Externí odkaz:
https://doaj.org/article/a014cc152eca4e2dac3eecdf4680cdf6
Autor:
Jennifer M. Bratt, Kevin Y. Chang, Michelle Rabowsky, Lisa M. Franzi, Sean P. Ott, Simone Filosto, Tzipora Goldkorn, Muhammad Arif, Jerold A. Last, Nicholas J. Kenyon, Amir A. Zeki
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 200, iss 11
Bratt, JM; Chang, KY; Rabowsky, M; Franzi, LM; Ott, SP; Filosto, S; et al.(2018). Farnesyltransferase inhibition exacerbates eosinophilic inflammation and airway hyperreactivity in mice with experimental asthma: The complex roles of ras GTPase and farnesylpyrophosphate in type 2 allergic inflammation. Journal of Immunology, 200(11), 3840-3856. doi: 10.4049/jimmunol.1601317. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9fx6h3fj
Bratt, JM; Chang, KY; Rabowsky, M; Franzi, LM; Ott, SP; Filosto, S; et al.(2018). Farnesyltransferase inhibition exacerbates eosinophilic inflammation and airway hyperreactivity in mice with experimental asthma: The complex roles of ras GTPase and farnesylpyrophosphate in type 2 allergic inflammation. Journal of Immunology, 200(11), 3840-3856. doi: 10.4049/jimmunol.1601317. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9fx6h3fj
Copyright © 2018 by The American Association of Immunologists, Inc. All right reserved. Ras, a small GTPase protein, is thought to mediate Th2-dependent eosinophilic inflammation in asthma. Ras requires cell membrane association for its biological a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4426185443c6f3ab9c0bf29f96eaa707
https://escholarship.org/uc/item/9fx6h3fj
https://escholarship.org/uc/item/9fx6h3fj
Autor:
Jerold A. Last
Publikováno v:
CRC Handbook of Animal Models of Pulmonary Disease ISBN: 9781351070966
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ec82f8d721ac05c9b2097851e47289
https://doi.org/10.1201/9781351070966-9
https://doi.org/10.1201/9781351070966-9
Publikováno v:
Toxicology and industrial health, vol 33, iss 3
Franzi, LM; Linderholm, AL; Rabowsky, M; & Last, JA. (2017). Lung toxicity in mice of airborne particulate matter from a modern layer hen facility containing Proposition 2-compliant animal caging. Toxicology and Industrial Health, 33(3), 211-221. doi: 10.1177/0748233716630490. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9n59864k
Franzi, LM; Linderholm, AL; Rabowsky, M; & Last, JA. (2017). Lung toxicity in mice of airborne particulate matter from a modern layer hen facility containing Proposition 2-compliant animal caging. Toxicology and Industrial Health, 33(3), 211-221. doi: 10.1177/0748233716630490. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9n59864k
© The Author(s) 2016. Proposition 2, which requires that egg-laying hens be confined only in ways that allow these animals to lie down, stand up, fully extend their limbs and turn around freely, was passed by the voters of California in 2008. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b95b2481b0fa0765f02be90677dc816
https://escholarship.org/uc/item/9n59864k
https://escholarship.org/uc/item/9n59864k
Autor:
Laura A. Cagle, Lisa M. Franzi, Steven E. Epstein, Philip H. Kass, Jerold A. Last, Nicholas J. Kenyon
Publikováno v:
Anesthesiology Research and Practice
Cagle, LA; Franzi, LM; Epstein, SE; Kass, PH; Last, JA; & Kenyon, NJ. (2017). Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol. Anesthesiology Research and Practice, 2017, 9161040. doi: 10.1155/2017/9161040. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6m48t8wq
Anesthesiology Research and Practice, Vol 2017 (2017)
Cagle, LA; Franzi, LM; Epstein, SE; Kass, PH; Last, JA; & Kenyon, NJ. (2017). Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol. Anesthesiology Research and Practice, 2017, 9161040. doi: 10.1155/2017/9161040. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6m48t8wq
Anesthesiology Research and Practice, Vol 2017 (2017)
Anesthetic protocols for murine models are varied within the literature and medetomidine has been implicated in the development of urethral plugs in male mice. Our objective was to evaluate the combination of butorphanol, dexmedetomidine, and tiletam
Publikováno v:
Toxicology and Applied Pharmacology. 266:48-55
Our previous work has shown that coarse particulate matter (PM10-2.5) from wildfire smoke is more toxic to lung macrophages on an equal dose (by mass) basis than coarse PM isolated from normal ambient air, as evidenced by decreased numbers of macroph
Autor:
Macarena Pírez, Gualberto Gonzalez-Sapienza, Daniel Sienra, Graciela Ferrari, Michael Last, Jerold A. Last, Beatriz M. Brena
Publikováno v:
Repositorio digital del LATU
Laboratorio Tecnológico del Uruguay
instacron:Laboratorio Tecnológico del Uruguay
Laboratorio Tecnológico del Uruguay
instacron:Laboratorio Tecnológico del Uruguay
In recent years, the international demand for commodities has prompted enormous growth in agriculture in most South American countries. Due to intensive use of fertilizers, cyanobacterial blooms have become a recurrent phenomenon throughout the conti