Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jeroen van den Berg"'
Autor:
Anchel de Jaime-Soguero, Janina Hattemer, Anja Bufe, Alexander Haas, Jeroen van den Berg, Vincent van Batenburg, Biswajit Das, Barbara di Marco, Stefania Androulaki, Nicolas Böhly, Jonathan J. M. Landry, Brigitte Schoell, Viviane S. Rosa, Laura Villacorta, Yagmur Baskan, Marleen Trapp, Vladimir Benes, Andrei Chabes, Marta Shahbazi, Anna Jauch, Ulrike Engel, Annarita Patrizi, Rocio Sotillo, Alexander van Oudenaarden, Josephine Bageritz, Julieta Alfonso, Holger Bastians, Sergio P. Acebrón
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Human development relies on the correct replication, maintenance and segregation of our genetic blueprints. How these processes are monitored across embryonic lineages, and why genomic mosaicism varies during development remain unknown. Usin
Externí odkaz:
https://doaj.org/article/02e8142c717c4f43bd91131e0cf9b945
Autor:
Femke M. Feringa, Lenno Krenning, André Koch, Jeroen van den Berg, Bram van den Broek, Kees Jalink, René H. Medema
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The DNA damage response induces a reversible arrest at different cell cycle stages. Here the authors find that loss of the APC/C inhibitor Emi1 in antephase (late G2) results in hypersensitivity to DNA damage and cell cycle exit at DNA damage levels
Externí odkaz:
https://doaj.org/article/a2284338e2d945e09762ac87bdafcf59
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2519-2527 (2016)
rDNA repeats constitute the most heavily transcribed region in the human genome. Tumors frequently display elevated levels of recombination in rDNA, indicating that the repeats are a liability to the genomic integrity of a cell. However, little is kn
Externí odkaz:
https://doaj.org/article/e20428a4d93a42a6b43e6081ba95cd6c
Autor:
Anoek Friskes, Lisa Koob, Lenno Krenning, Tesa M Severson, Emma S Koeleman, Xabier Vergara, Michael Schubert, Jeroen van den Berg, Bastiaan Evers, Anna G Manjón, Stacey Joosten, Yongsoo Kim, Wilbert Zwart, René H Medema
Publikováno v:
Friskes, A, Koob, L, Krenning, L, Severson, T M, Koeleman, E S, Vergara, X, Schubert, M, van den Berg, J, Evers, B, Manjón, A G, Joosten, S, Kim, Y, Zwart, W & Medema, R H 2022, ' Double-strand break toxicity is chromatin context independent ', Nucleic Acids Research, vol. 50, no. 17, pp. 9930-9947 . https://doi.org/10.1093/nar/gkac758
Nucleic Acids Research, 50(17), 9930-9947. Oxford University Press
Nucleic Acids Research, 50(17), 9930-9947. Oxford University Press
Cells respond to double-strand breaks (DSBs) by activating DNA damage response pathways, including cell cycle arrest. We have previously shown that a single double-strand break generated via CRISPR/Cas9 is sufficient to delay cell cycle progression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3aa9f1cdbb010bdf6fb2581f0314d44
https://doi.org/10.1093/nar/gkac758
https://doi.org/10.1093/nar/gkac758
In a human cell thousands of replication forks simultaneously coordinate the duplication of the entire genome. The rate at which this process occurs, might depend on the epigenetic state of the genome and vary between, or even within, cell types. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a317d9cdd1f833e3a52466ab28298cbe
https://doi.org/10.1101/2022.12.13.520365
https://doi.org/10.1101/2022.12.13.520365
Autor:
Kathleen Stout, Roeland J. M. Nolte, Mathijs F. J. Mabesoone, Fabian L L Visschers, Jeroen van den Berg, Joëlle-Rose Klop, Alan E. Rowan, Theo P. J. Peters, Eline M Meijer, Johannes A. A. W. Elemans, Paul B. White
Publikováno v:
European Journal of Organic Chemistry, 2020, 7087-7100
European Journal of Organic Chemistry
European Journal of Organic Chemistry, 2020, 45, pp. 7087-7100
European Journal of Organic Chemistry
European Journal of Organic Chemistry, 2020, 45, pp. 7087-7100
The synthesis and characterization of double porphyrin cage compounds are described. They consist of two porphyrins that are each attached to a diphenylglycoluril‐based clip molecule via four ethyleneoxy spacers, and are linked together by a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e602fa6197dd551a63d4dceecd94800
https://doi.org/10.1002/ejoc.202001211
https://doi.org/10.1002/ejoc.202001211
Autor:
Alexander van Oudenaarden, Jeroen van den Berg, Hans Clevers, Michael VanInsberghe, Amanda Andersson-Rolf
Publikováno v:
Nature, 597(7877), 561-565. Nature Publishing Group
Nature
Nature
Single-cell sequencing methods have enabled in-depth analysis of the diversity of cell types and cell states in a wide range of organisms. These tools focus predominantly on sequencing the genomes1, epigenomes2 and transcriptomes3 of single cells. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c9e6f50dab6951271d143ed3929742
https://pure.knaw.nl/portal/en/publications/3c0f71fd-6beb-49e3-b498-a7a31998987b
https://pure.knaw.nl/portal/en/publications/3c0f71fd-6beb-49e3-b498-a7a31998987b
Autor:
Xabier Vergara, Ruben Schep, Ben Morris, Jeroen van den Berg, Tom van Schaik, Christ Leemans, Eva K. Brinkman, Daniel Peric-Hupkes, Roderick L. Beijersbergen, Stefano G. Manzo, Bas van Steensel, René H. Medema
DNA double-strand break (DSB) repair is mediated by multiple pathways, including classical non-homologous end-joining pathway (NHEJ) and several homology-driven repair pathways. This is particularly important for Cas9-mediated genome editing, where t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a628966fdb13401d141ed9324f6ba6
https://doi.org/10.1101/2020.05.05.078436
https://doi.org/10.1101/2020.05.05.078436
Autor:
Femke M. Feringa, Anna G. Manjón, Yongsoo Kim, Wilbert Zwart, Jeroen van den Berg, Lenno Krenning, Bram van den Broek, Lisa Koob, Kees Jalink, René H. Medema, Stacey E. P. Joosten, Rob Klompmaker
The authors have withdrawn their manuscript whilst they perform additional experiments to test some of their conclusions further.Despite repetitive attempts to reproduce the data shown in figure 2I, we have failed to obtain convincing evidence that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9d6a94fe201de1fd075928167cf095
Autor:
Bas van Steensel, René H. Medema, Ruben Schep, Ben Morris, Tom van Schaik, Robin H. van der Weide, Xabier Vergara, Roderick L. Beijersbergen, Jeroen van den Berg, Eva K. Brinkman, Daniel Peric-Hupkes, Stefano G. Manzo, Christ Leemans
Publikováno v:
Mol. Cell
Molecular Cell, 81(10), 2216-2230.e10. Cell Press
Molecular Cell
Molecular Cell, 81(10), 2216-2230.e10. Cell Press
Molecular Cell
Summary DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that the local chromatin context affects the pathway choice, but the underlying principles are poorly understood. Using a multiplexed reporter assay in combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628e5dd774dc65fb3af3e09c7f400523
https://doi.org/10.1016/j.molcel.2021.03.032
https://doi.org/10.1016/j.molcel.2021.03.032