Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Jeroen Pollet"'
Autor:
Peter J. Hotez, Maria Elena Bottazzi, Nelufa Yesmin Islam, Jungsoon Lee, Jeroen Pollet, Cristina Poveda, Ulrich Strych, Syamala Rani Thimmiraju, Nestor L. Uzcategui, Leroy Versteeg, Daniel Gorelick
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 535-545 (2024)
ABSTRACTIntroduction Zebrafishes represent a proven model for human diseases and systems biology, exhibiting physiological and genetic similarities and having innate and adaptive immune systems. However, they are underexplored for human vaccinology,
Externí odkaz:
https://doaj.org/article/7b5259018f2c4102869b765483e32b3f
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 174-185 (2024)
ABSTRACTIntroduction Pseudoviruses are recombinant, replication-incompetent, viral particles designed to mimic the surface characteristics of native enveloped viruses. They are a safer, and cost-effective research alternative to live viruses. With th
Externí odkaz:
https://doaj.org/article/e2ab898358f44369bbe76947ec020885
Autor:
Syamala Rani Thimmiraju, Rakesh Adhikari, JeAnna R. Redd, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Yi-Lin Chen, Suman Sharma, Amandeep Kaur, Nestor L. Uzcategui, Shannon E. Ronca, Wen-Hsiang Chen, Jason T. Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-5 (2024)
Abstract The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV,
Externí odkaz:
https://doaj.org/article/44e886df60de4b48bf25ffd2242f40b2
Autor:
Peter J. Hotez, Rakesh Adhikari, Wen-Hsiang Chen, Yi-Lin Chen, Portia Gillespie, Nelufa Y. Islam, Brian Keegan, Rakhi Tyagi Kundu, Jungsoon Lee, Zhuyun Liu, Jason T. Kimata, Numan Oezguen, Jeroen Pollet, Cristina Poveda, Kay Razavi, Shannon E. Ronca, Ulrich Strych, Syamala R. Thimmiraju, Leroy Versteeg, Maria Jose Villar-Mondragon, Junfei Wei, Bin Zhan, Maria Elena Bottazzi
Publikováno v:
Expert Review of Vaccines, Vol 22, Iss 1, Pp 495-500 (2023)
Introduction The development of a yeast-expressed recombinant protein-based vaccine technology co-developed with LMIC vaccine producers and suitable as a COVID-19 vaccine for global access is described. The proof-of-concept for developing a SARS-CoV-
Externí odkaz:
https://doaj.org/article/9dc912870f71410b853d29ac8af90252
Autor:
Syamala Rani Thimmiraju, Maria Jose Villar, Jason T. Kimata, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet
Publikováno v:
Viruses, Vol 16, Iss 9, p 1492 (2024)
Over the past three years, new SARS-CoV-2 variants have continuously emerged, evolving to a point where an immune response against the original vaccine no longer provided optimal protection against these new strains. During this time, high-throughput
Externí odkaz:
https://doaj.org/article/86980087e3fe48809ff791f0d35f29d4
Autor:
Zongyuan Liu, Rebecca Ulrich vonBargen, April L. Kendricks, Kate Wheeler, Ana Carolina Leão, Krithivasan Sankaranarayanan, Danya A. Dean, Shelley S. Kane, Ekram Hossain, Jeroen Pollet, Maria Elena Bottazzi, Peter J. Hotez, Kathryn M. Jones, Laura-Isobel McCall
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Post-infectious conditions present major health burdens but remain poorly understood. In Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that successfully clear T. cruzi do not always improve clinical outcome
Externí odkaz:
https://doaj.org/article/ece30cfd780f4288923b0c11f864e0a8
Autor:
Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M. Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C. Faver, Pranavanand Nyshadham, Kiran L. Sharma, Banumathi Sankaran, Allison Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S. Harris, Martin M. Matzuk, Timothy Palzkill, Damian W. Young
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate Mpro inhibitors, which
Externí odkaz:
https://doaj.org/article/aab44f4c21884a5ab19d7b954a87359d
Autor:
William R. Lykins, Jeroen Pollet, Jessica A. White, Brian Keegan, Leroy Versteeg, Ulrich Strych, Wen-Hsiang Chen, Raodoh Mohamath, Gabi Ramer-Denisoff, Sierra Reed, Samuel Beaver, Alana Gerhardt, Emily A. Voigt, Mark A. Tomai, Robert Sitrin, Robert K. M. Choy, Frederick J. Cassels, Peter J. Hotez, Maria Elena Bottazzi, Christopher B. Fox
Publikováno v:
Frontiers in Drug Delivery, Vol 4 (2024)
Introduction: Since their introduction, adjuvanted recombinant subunit vaccines against COVID-19 have played a pivotal role in protecting global populations. Optimizing the immune response’s quality, amplitude, and durability to these vaccines depe
Externí odkaz:
https://doaj.org/article/f548c0f6edd64e56889f7e3269b838a0
Autor:
Duc Minh Nguyen, Cristina Poveda, Jeroen Pollet, Fabian Gusovsky, Maria Elena Bottazzi, Peter J Hotez, Kathryn Marie Jones
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011519 (2023)
BackgroundChagas disease, chronic infection with Trypanosoma cruzi, mainly manifests as cardiac disease. However, the liver is important for both controlling parasite burdens and metabolizing drugs. Notably, high doses of anti-parasitic drug benznida
Externí odkaz:
https://doaj.org/article/1a67838d992942c3894c9ef56f930384
Autor:
Syamala Rani Thimmiraju, Rakesh Adhikari, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Rakhi Kundu, Yi-Lin Chen, Suman Sharma, Karm Ghei, Brian Keegan, Leroy Versteeg, Portia M. Gillespie, Allan Ciciriello, Nelufa Y. Islam, Cristina Poveda, Nestor Uzcategui, Wen-Hsiang Chen, Jason T. Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, Jeroen Pollet
Publikováno v:
Vaccines, Vol 11, Iss 10, p 1557 (2023)
(1) Background: We previously reported the development of a recombinant protein SARS-CoV-2 vaccine, consisting of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, adjuvanted with aluminum hydroxide (alum) and CpG oligonucleotides. I
Externí odkaz:
https://doaj.org/article/e8dbfb4ddd6846bc8029464d5b8e6255