Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Jeroen P J, Saeij"'
Autor:
Mebratu A. Bitew, Pablo S. Gaete, Christopher Swale, Parag Maru, Jorge E. Contreras, Jeroen P. J. Saeij
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Toxoplasma gondii, a medically important intracellular parasite, uses GRA proteins secreted from dense granule organelles to mediate nutrient flux across the parasitophorous vacuole membrane (PVM). GRA17 and GRA23 are known pore-forming prot
Externí odkaz:
https://doaj.org/article/a9e7c683dca44926a28c7b2713c37571
Autor:
Yifan Wang, L. Robert Hollingsworth, Lamba Omar Sangaré, Tatiana C. Paredes-Santos, Shruthi Krishnamurthy, Bennett H. Penn, Hao Wu, Jeroen P. J. Saeij
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Toxoplasma gondii is an intracellular parasite that can activate the NLRP1 inflammasome leading to macrophage pyroptosis in Lewis rats, but the underlying mechanism is not well understood. In this study, we performed a genome-wide CRISPR scr
Externí odkaz:
https://doaj.org/article/1f12e478b874473fb773f6d60dec647f
Autor:
Tatiana C Paredes-Santos, Mebratu A Bitew, Christopher Swale, Felipe Rodriguez, Shruthi Krishnamurthy, Yifan Wang, Parag Maru, Lamba Omar Sangaré, Jeroen P J Saeij
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011543 (2023)
Toxoplasma gondii is a parasite that replicates within a specialized compartment called the parasitophorous vacuole (PV), which is surrounded by the PV membrane (PVM). To obtain essential nutrients, Toxoplasma must transport molecules across the PVM,
Externí odkaz:
https://doaj.org/article/7763f771c336474c8ad688a4b1eebc12
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides an important phy
Externí odkaz:
https://doaj.org/article/21e0b6454b854c83a2e73a81c579e5d2
Autor:
Shruthi Krishnamurthy, Parag Maru, Yifan Wang, Mebratu A. Bitew, Debanjan Mukhopadhyay, Yoshiki Yamaryo-Botté, Tatiana C. Paredes-Santos, Lamba O. Sangaré, Christopher Swale, Cyrille Y. Botté, Jeroen P. J. Saeij
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved in the evasion of the murine IFNγ response have been identified, genes
Externí odkaz:
https://doaj.org/article/aa0b609ab8e24e4ba3325ba254cf6795
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The obligate intracellular parasite Toxoplasma gondii makes use of infected leukocytes for systemic dissemination. Yet, how infection impacts the processes of leukocyte diapedesis has remained unresolved. Here, we addressed the effects of T. gondii i
Externí odkaz:
https://doaj.org/article/a47ad953ca824b4bb3b987bd54844829
Autor:
David Arranz-Solís, Jeroen P. J. Saeij
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Toxoplasmosis is a worldwide disease affecting all warm-blooded animals, including humans. Vaccination strategies aimed at inducing an efficient immune response while preventing transmission have been attempted in the past. While many different appro
Externí odkaz:
https://doaj.org/article/142f3d05efae454a85536f2c8b0accf6
Autor:
Yifan Wang, Lamba Omar Sangaré, Tatiana C. Paredes-Santos, Musa A. Hassan, Shruthi Krishnamurthy, Anna M. Furuta, Benedikt M. Markus, Sebastian Lourido, Jeroen P. J. Saeij
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Using a genome-wide CRISPR screen, the authors here identify Toxoplasma genes that counteract the anti-parasitic activity of interferon gamma in murine macrophages. One of these genes, dense granule protein GRA45, is critical for the trafficking of G
Externí odkaz:
https://doaj.org/article/68a66b36b97c4e1683d45043107bffd4
Autor:
Laura Rico-San Román, Rafael Amieva, Javier Regidor-Cerrillo, Marta García-Sánchez, Esther Collantes-Fernández, Iván Pastor-Fernández, Jeroen P. J. Saeij, Luis Miguel Ortega-Mora, Pilar Horcajo
Publikováno v:
Pathogens, Vol 11, Iss 9, p 998 (2022)
The intraspecific variability among Neospora caninum isolates in their in vitro behaviour and in vivo virulence has been widely studied. In particular, transcriptomic and proteomic analyses have shown a higher expression/abundance of specific genes/p
Externí odkaz:
https://doaj.org/article/aa7402afa3be45f1822019e8906efc32
Autor:
Taylor G. Glausen, Gabriela L. Carrillo, Richard M. Jin, Jon P. Boyle, Jeroen P. J. Saeij, Elizabeth A. Wohlfert, Michael A. Fox, Ira J. Blader
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Inflammation in the brain caused by infections lead to seizures and other neurological symptoms. But the microbial products that induce seizures as well as the host pathways downstream of these factors are largely unknown.
Externí odkaz:
https://doaj.org/article/009cc65add2f48c0955f42782c833842