Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jeroen M. Bugter"'
Autor:
Michaela Reissland, Oliver Hartmann, Saskia Tauch, Cristian Prieto-Garcia, Clemens Schulte, Daniel Solvie, Sinah Loebbert, Anne-Claire Jacomin, Marina Pesic, Jeroen M. Bugter, Christina Schuelein-Voelk, Carmina T. Fuss, Nikolet Pahor, Carsten Ade, Viktoria Buck, Michael Potente, Vivian Li, Gerti Beliu, Armin Wiegering, Eliya Bitman-Lotan, Tom Grossmann, Mathias Rosenfeldt, Martin Eilers, Hans Maric, Madelon M. Maurice, Florian Greten, Ivan Dikič, Amir Orian, Peter Gallant, Markus E. Diefenbacher
SummaryThe contribution of deubiquitylating enzymes to β-Catenin stabilisation in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here, we report the deubiquitylase USP10 as an APC-truncation- specific enhancer of β-Catenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07cbccc13dc3cb445f4a5957beac5545
https://doi.org/10.1101/2023.02.10.527983
https://doi.org/10.1101/2023.02.10.527983
Autor:
Jeroen M. Bugter, Layla El Bouazzaoui, Emre Küçükköse, Yourae Hong, Joep Sprangers, Ingrid Jordens, Nicola Fenderico, Diego Montiel Gonzalez, Ruben van Boxtel, Saskia J.E. Suijkerbuijk, Sabine Tejpar, Hugo J.G. Snippert, Onno Kranenburg, Madelon M. Maurice
SummaryIn colorectal cancer (CRC),RNF43mutations are linked to BRAF V600E-initiated serrated adenomas that advance into mucinous adenocarcinomas with poor prognosis upon metastasis. HowRNF43mutations facilitate a metastasis-prone growth state remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8cba2e1f0abcb057fa8c17979351af5
https://doi.org/10.1101/2022.12.22.521159
https://doi.org/10.1101/2022.12.22.521159
Publikováno v:
Nature Reviews Cancer. 21:5-21
Mutation-induced activation of WNT-β-catenin signalling is a frequent driver event in human cancer. Sustained WNT-β-catenin pathway activation endows cancer cells with sustained self-renewing growth properties and is associated with therapy resista
Publikováno v:
Nature reviews. Cancer. 21(1)
Mutation-induced activation of WNT-β-catenin signalling is a frequent driver event in human cancer. Sustained WNT-β-catenin pathway activation endows cancer cells with sustained self-renewing growth properties and is associated with therapy resista
Autor:
Michiel Vermeulen, Madelon M. Maurice, Lars Ootes, Maureen Spit, Jeroen M. Bugter, Sylvia F. Boj, Tomasz Witold Radaszkiewicz, Jan Paul Medema, Alba Cristobal, Katerina Hanakova, Max van Osch, Eline Janssen, Vitezslav Bryja, Bon-Kyoung Koo, David Potesil, Zbynek Zdrahal, Kim E. Boonekamp, Rik G.H. Lindeboom, Ingrid Jordens, Nicola Fenderico
Publikováno v:
The EMBO Journal
EMBO journal, 39(18):e103932. Wiley-Blackwell
EMBO Journal, 39
EMBO Journal, 39, 18
EMBO journal, 39(18):e103932. Wiley-Blackwell
EMBO Journal, 39
EMBO Journal, 39, 18
Wnt/β‐catenin signaling is a primary pathway for stem cell maintenance during tissue renewal and a frequent target for mutations in cancer. Impaired Wnt receptor endocytosis due to loss of the ubiquitin ligase RNF43 gives rise to Wnt‐hypersensit
Publikováno v:
Nature Reviews Cancer. 21:64-64
Autor:
Jeroen M. Bugter, Teck Yew Low, Madelon M. Maurice, Ineke van 't Land-Kuper, Daniele V.F. Tauriello, Catherine Rabouille, Ingrid Jordens, Felipe X. Pimentel-Muiños, Nicola Fenderico, Albert J. R. Heck, Ivar Noordstra, Despina Xanthakis, Jan P. Gerlach, Johanneke van der Kooij, David A. Egan
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 115(17), E3996-E4005. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 115(17), E3996
Digital.CSIC. Repositorio Institucional del CSIC
instname
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 115(17), E3996-E4005. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 115(17), E3996
Digital.CSIC. Repositorio Institucional del CSIC
instname
Proceedings of the National Academy of Sciences of the United States of America
Wnt/β-catenin signaling controls development and adult tissue homeostasis by regulating cell proliferation and cell fate decisions. Wnt binding to its receptors Frizzled (FZD) and low-density lipoprotein-related 6 (LRP6) at the cell surface initiate