Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jeroen F J Bogie"'
Autor:
Sam Vanherle, Jeroen Guns, Melanie Loix, Fleur Mingneau, Tess Dierckx, Flore Wouters, Koen Kuipers, Tim Vangansewinkel, Esther Wolfs, Paula Pincela Lins, Annelies Bronckaers, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Sanne G. S. Verberk, Mansour Haidar, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benig
Externí odkaz:
https://doaj.org/article/a6e816db044d4b4cb16b68a2c6586fad
Autor:
Tess Dierckx, Mansour Haidar, Elien Grajchen, Elien Wouters, Sam Vanherle, Melanie Loix, Annick Boeykens, Dany Bylemans, Kévin Hardonnière, Saadia Kerdine-Römer, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Macrophages play a dual role in neuroinflammatory disorders such as multiple sclerosis (MS). They are involved in lesion onset and progression but can also promote the resolution of inflammation and repair of damaged tissue. In th
Externí odkaz:
https://doaj.org/article/a5263a25384c45e78a99d4b06ce71e49
Autor:
Elien Grajchen, Elien Wouters, Britt van de Haterd, Mansour Haidar, Kévin Hardonnière, Tess Dierckx, Jana Van Broeckhoven, Celine Erens, Sven Hendrix, Saadia Kerdine-Römer, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background The presence of foamy macrophages and microglia containing intracellular myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple sclerosis (MS). Despite the importance of myelin internalization i
Externí odkaz:
https://doaj.org/article/48a6620689ed48feb27566498ac8333d
Autor:
Elien Grajchen, Melanie Loix, Paulien Baeten, Beatriz F. Côrte-Real, Ibrahim Hamad, Sam Vanherle, Mansour Haidar, Jonas Dehairs, Jelle Y. Broos, James M. Ntambi, Robert Zimmermann, Rolf Breinbauer, Piet Stinissen, Niels Hellings, Sanne G. S. Verberk, Gijs Kooij, Martin Giera, Johannes V. Swinnen, Bieke Broux, Markus Kleinewietfeld, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Publikováno v:
Cellular and Molecular Immunology, 20(6), 666-679. Nature Publishing Group
Grajchen, E, Loix, M, Baeten, P, Côrte-Real, B F, Hamad, I, Vanherle, S, Haidar, M, Dehairs, J, Broos, J Y, Ntambi, J M, Zimmermann, R, Breinbauer, R, Stinissen, P, Hellings, N, Verberk, S G S, Kooij, G, Giera, M, Swinnen, J V, Broux, B, Kleinewietfeld, M, Hendriks, J J A & Bogie, J F J 2023, ' Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity ', Cellular and Molecular Immunology, vol. 20, no. 6, pp. 666-679 . https://doi.org/10.1038/s41423-023-01011-2
Grajchen, E, Loix, M, Baeten, P, Côrte-Real, B F, Hamad, I, Vanherle, S, Haidar, M, Dehairs, J, Broos, J Y, Ntambi, J M, Zimmermann, R, Breinbauer, R, Stinissen, P, Hellings, N, Verberk, S G S, Kooij, G, Giera, M, Swinnen, J V, Broux, B, Kleinewietfeld, M, Hendriks, J J A & Bogie, J F J 2023, ' Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity ', Cellular and Molecular Immunology, vol. 20, no. 6, pp. 666-679 . https://doi.org/10.1038/s41423-023-01011-2
The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis (MS). Emerging evidence indicates that endogenous and dietary-induced changes in fatty acid metabolism have a majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0453077196c63a160f7fb022361b2740
https://cris.maastrichtuniversity.nl/en/publications/91c2f0c1-489d-4001-92ff-b59bf00eacea
https://cris.maastrichtuniversity.nl/en/publications/91c2f0c1-489d-4001-92ff-b59bf00eacea
Publikováno v:
Cells, Vol 11, Iss 3, p 565 (2022)
Macrophages are present in all tissues within our body, where they promote tissue homeostasis by responding to microenvironmental triggers, not only through clearance of pathogens and apoptotic cells but also via trophic, regulatory, and repair funct
Externí odkaz:
https://doaj.org/article/a762dbc73e5d4e888e4ece587ae7b24f
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-21 (2018)
Abstract Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions mainly consist of macrophages and microglia containing abunda
Externí odkaz:
https://doaj.org/article/da9107dda70b4e03834bad83cf52bddd
Autor:
Elien Wouters, Nienke M. de Wit, Jasmine Vanmol, Susanne M. A. van der Pol, Bert van het Hof, Daniela Sommer, Melanie Loix, Dirk Geerts, Jan Ake Gustafsson, Knut R. Steffensen, Tim Vanmierlo, Jeroen F. J. Bogie, Jerome J. A. Hendriks, Helga E. de Vries
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Dysfunction of the blood-brain barrier (BBB) contributes significantly to the pathogenesis of several neuroinflammatory diseases, including multiple sclerosis (MS). Potential players that regulate BBB function are the liver X receptors (LXRs), which
Externí odkaz:
https://doaj.org/article/56fc8933ec1142a69ee5c39bf8b09233
Autor:
Niamh B. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, Alana Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W. McColl, Marco Prinz, Tara L. Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J. A. Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E. Miron
Publikováno v:
Nature 613(7942), 120-129 (2023). doi:10.1038/s41586-022-05534-y
Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health1, it is unknown w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228d404a8611c8450df3d12b1580b5c6
Autor:
Tess Dierckx, Sam Vanherle, Mansour Haidar, Elien Grajchen, Fleur Mingneau, Pascal Gervois, Esther Wolfs, Dany Bylemans, Arnout Voet, Tien Nguyen, Ibrahim Hamad, Markus Kleinewietfeld, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Why endogenous repair mechanisms frequently fail in these disorders is poorly understood. However, there is now evidence indicating that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f024a9bb3e5f1f919c32faaa47810597
https://doi.org/10.1073/pnas.2120393119
https://doi.org/10.1073/pnas.2120393119
Autor:
Jo Mailleux, Silke Timmermans, Katherine Nelissen, Jasmine Vanmol, Tim Vanmierlo, Jack van Horssen, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
ObjectiveWe aimed to determine the role of the low-density lipoprotein receptor (LDLr) in neuroinflammation by inducing experimental autoimmune encephalomyelitis (EAE) in ldlr knock out mice.MethodsMOG35–55 induced EAE in male and female ldlr−/
Externí odkaz:
https://doaj.org/article/656e348ab9024115bd1bac24d39df599