Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeroen Claus"'
Autor:
Selene Roberts, Michael Hirsch, Alexandra McStea, Laura Zanetti-Domingues, David Clarke, Jeroen Claus, Peter Parker, Lin Wang, Marisa Martin-Fernandez
Publikováno v:
Bio-Protocol, Vol 8, Iss 23 (2018)
The Human Epidermal Growth Factor Receptor (HER) family of receptor tyrosine kinases consists of four, single pass, transmembrane receptor homologs (HER1-4) that act to regulate many critical processes in normal and tumor cells. HER2 is overexpressed
Externí odkaz:
https://doaj.org/article/8c5533c0d7f745aaa90ef476b7b2a1db
Autor:
Jeroen Claus, Gargi Patel, Flavia Autore, Audrey Colomba, Gregory Weitsman, Tanya N Soliman, Selene Roberts, Laura C Zanetti-Domingues, Michael Hirsch, Francesca Collu, Roger George, Elena Ortiz-Zapater, Paul R Barber, Boris Vojnovic, Yosef Yarden, Marisa L Martin-Fernandez, Angus Cameron, Franca Fraternali, Tony Ng, Peter J Parker
Publikováno v:
eLife, Vol 7 (2018)
While targeted therapy against HER2 is an effective first-line treatment in HER2+ breast cancer, acquired resistance remains a clinical challenge. The pseudokinase HER3, heterodimerisation partner of HER2, is widely implicated in the resistance to HE
Externí odkaz:
https://doaj.org/article/05bdc0b657ae488494f7ad21996d47c6
Autor:
Jahangir Sufi, Jeroen Claus, Petra Vlckova, Christopher Tape, Xiao Qin, Ferran Cardoso Rodriguez
Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell-fate in colorectal cancer (CRC), we pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5ce9cbb4a84d64590146c3eca249dfb
https://doi.org/10.1101/2023.02.15.528008
https://doi.org/10.1101/2023.02.15.528008
Autor:
Audrey, Colomba, Jeroen, Claus, Forson, Gao, Roger, George, Arianna, Fornili, Angus J M, Cameron
Publikováno v:
Methods in enzymology. 667
HER3 is a potent oncogenic growth factor receptor belonging to the human epidermal growth factor (HER/EGFR) family of receptor tyrosine kinases. In contrast to other EGFR family members, HER3 is a pseudokinase, lacking functional kinase activity. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0b81be09da489620b74f409b8738f27
https://pubmed.ncbi.nlm.nih.gov/35525551
https://pubmed.ncbi.nlm.nih.gov/35525551
Autor:
David M. Smith, Gregory Weitsman, Michael Hirsch, Ambrosius P. Snijders, Svend Kjaer, Roger George, Peter J. Parker, Shahid Mehmood, Daniel J. Rolfe, Marisa L. Martin-Fernandez, Jeroen Claus, Tony Ng, Selene K. Roberts, Martina Fitzek, Laura C. Zanetti-Domingues, Audrey Colomba, Andrew Madin
Publikováno v:
Biochemical Journal
Despite being catalytically defective, pseudokinases are typically essential players of cellular signalling, acting as allosteric regulators of their active counterparts. Deregulation of a growing number of pseudokinases has been linked to human dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7379b2f95fb20dcf6e78c913982571d
http://europepmc.org/articles/PMC7489893
http://europepmc.org/articles/PMC7489893
Publikováno v:
Methods in Enzymology ISBN: 9780323915410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb4ce2c96d0f3f7e1bbc99f2bc6d451
https://doi.org/10.1016/bs.mie.2022.03.044
https://doi.org/10.1016/bs.mie.2022.03.044
Autor:
Alexandra McStea, Peter J. Parker, David T. Clarke, Selene K. Roberts, Jeroen Claus, Marisa L. Martin-Fernande, Michael Hirsch, Lin Wang, Laura C. Zanetti-Domingues
Publikováno v:
Bio Protoc
The Human Epidermal Growth Factor Receptor (HER) family of receptor tyrosine kinases consists of four, single pass, transmembrane receptor homologs (HER1-4) that act to regulate many critical processes in normal and tumor cells. HER2 is overexpressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1439ded8e91c39d035683a4e184cd3b1
https://pubmed.ncbi.nlm.nih.gov/34532543
https://pubmed.ncbi.nlm.nih.gov/34532543
Autor:
Paul R. Barber, Yosef Yarden, Roger George, Gargi Patel, Flavia Autore, Boris Vojnovic, Gregory Weitsman, Audrey Colomba, Marisa L. Martin-Fernandez, Selene K. Roberts, Peter J. Parker, Laura C. Zanetti-Domingues, Tony Ng, Michael Hirsch, Francesca Collu, Angus J.M. Cameron, Franca Fraternali, Tanya N. Soliman, Elena Ortiz-Zapater, Jeroen Claus
Publikováno v:
Claus, J, Patel, G, Autore, F, Colomba, A, Weitsman, G, Soliman, T N, Roberts, S, Zanetti Domingues, L C, Hirsch, M, Collu, F, George, R, Ortiz-Zapater, E, Barber, P R, Vojnovic, B, Yarden, Y, Martin-Fernandez, M L, Cameron, A, Fraternali, F, Ng, T & Parker, P J 2018, ' Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface ', eLife, vol. 7, e32271 . https://doi.org/10.7554/eLife.32271
eLife
eLife, Vol 7 (2018)
eLife
eLife, Vol 7 (2018)
While targeted therapy against HER2 is an effective first-line treatment in HER2+ breast cancer, acquired resistance remains a clinical challenge. The pseudokinase HER3, heterodimerisation partner of HER2, is widely implicated in the resistance to HE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710cfdc7ac40e5df3cb72c57279b1b1a
https://doi.org/10.7554/elife.32271
https://doi.org/10.7554/elife.32271
Autor:
Francesca Collu, Tony Ng, Paul R. Barber, Jeroen Claus, Gargi Patel, Franca Fraternali, Gregory Weitsman, Angus J.M. Cameron, Michael Hirsch, Peter J. Parker, Roger George, Flavia Autore, Marisa L. Martin-Fernandez, Laura C. Zanetti-Domingues, Boris Vojnovic, Yosef Yarden, Tanya N. Soliman, Elena Ortiz-Zapater, Selene K. Roberts, Audrey Colomba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec3894b79dd4cc103426160cb78a6061
https://doi.org/10.7554/elife.32271.037
https://doi.org/10.7554/elife.32271.037
Publikováno v:
Biochemical Society Transactions. 42:1534-1537
Cytokinesis is the final act of the cell cycle where the replicated DNA and cellular contents are finally split into two daughter cells. This process is very tightly controlled as DNA segregation errors and cytokinesis failure is commonly associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2921c5ae48fb5ae907b6a02ca0e09a67
https://doi.org/10.1042/bst20140240
https://doi.org/10.1042/bst20140240