Application of monodentate secondary phosphine oxides, a new class of chiral ligands, in Ir(I)-catalyzed asymmetric imine hydrogenation

Autor: Jeroen A. F. Boogers, de Johannes Vries, Xiao-bin Jiang, Adriaan J. Minnaard, Bernard Feringa, A.L.L. Duchateau, J.G.O. Andrien, A. L. L. Duschateau, B. Hessen

Publikováno v: Organic letters, 5(9), 1503-1506. AMER CHEMICAL SOC INC

Secondary phosphine oxides were prepared from R(1)PCl(2) and R(2)MgBr, followed by hydrolysis. They were obtained in an enantiopure form by preparative chiral HPLC. These new monodentate ligands were tested in the iridium-catalyzed hydrogenation of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd84b69216c299581e04b0a51f0edfb
https://doi.org/10.1021/ol034282u

Improving conversion and enantioselectivity in hydrogenation by combining different monodentate phosphoramidites; a new combinatorial approach in asymmetric catalysisElectronic supplementary information (ESI) available: Experimental details. See http://www.rsc.org/suppdata/ob/b3/b302097e

Autor: Jeroen A. F. Boogers, Diego Peña, Adriaan J. Minnaard, Johannes G. de Vries, Bernard Feringa, André H.M. de Vries

Publikováno v: Organic & Biomolecular Chemistry. 1:1087-1089

The combination of monodentate ligands in the rhodium-catalysed enantioselective hydrogenation enables a new approach when searching for the optimal activity and enantioselectivity in catalysis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b73ba24a7c939d061019288cd48440ec
https://doi.org/10.1039/b302097e

Asymmetric hydrogenation of a 2-isopropylcinnamic acid derivative en route to the blood pressure-lowering agent Aliskiren

Autor: Dirk Sartor, André H.M. de Vries, Gerhard Steinbauer, Laurent Lefort, Martina Kotthaus, Johannes G. de Vries, Bert Dielemans, Ulf Felfer, Jeroen A. F. Boogers

Publikováno v: Asymmetric Catalysis on Industrial Scale: Challenges, Approaches, Solutions, 127-150
ISSUE=2nd;STARTPAGE=127;ENDPAGE=150;TITLE=Asymmetric Catalysis on Industrial Scale
Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions, Second Edition

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https://research.rug.nl/en/publications/b2c07b80-65b2-4965-8db8-028dc7829bb8

Rapid Identification of a Scalable Catalyst for the Asymmetric Hydrogenation of a Sterically Demanding Aryl Enamide

Autor: Harrie Straatman, Jeroen A. F. Boogers, Laurent Lefort, André H.M. de Vries, Johannes G. de Vries, John Janssen, Robert Jan Vijn, Thijs Kuilman

Publikováno v: Organic Process Research & Development, 14(3), 568-573. AMER CHEMICAL SOC INC

High throughput screening was used to find a cost-effective and scalable catalyst for the asymmetric hydrogenation of a sterically demanding enamide as an intermediate towards a new potent melanocortin receptor agonist useful in the treatment of obes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717024efac08679bf65f1e42bea3cbb5
https://research.rug.nl/en/publications/d6615bcc-d3b2-4d98-a222-9a4dc9ca34c3

Soluble iron nanoparticles as cheap and environmentally benign alkene and alkyne hydrogenation catalysts

Autor: Jeroen A. F. Boogers, Johannes G. de Vries, Laurent Lefort, Pim-Huat Phua, Mar Tristany

Publikováno v: Chemical Communications, 40(45), 3747-3749. ROYAL SOC CHEMISTRY

Iron nanoparticles prepared by reducing FeCl3 with three equivalents of EtMgCl in THF are effective catalysts for the hydrogenation of alkenes and alkynes under moderate conditions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82342cc4e443516ec3fe1ba5beddc43d
https://research.rug.nl/en/publications/9cdb6b7b-8a69-4acc-b136-1be7c997abcd