Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Jeroen A. Sierts"'
1
Heterozygosity for a Loss-of-Function Mutation in GALNT2 Improves Plasma Triglyceride Clearance in Man
Autor: Stefan Ljunggren, Helen Karlsson, Dirk Lefeber, Geesje M. Dallinga-Thie, Johannes M. F. G. Aerts, Daniel S. Herman, Johannes H.M. Levels, Erik S.G. Stroes, John J.P. Kastelein, Eva Morava, Jan Albert Kuivenhoven, Thomas M. Beres, Ruei Shiuan Lin, Jonathan G. Seidman, M. Mahdi Motazacker, Aeilko H. Zwinderman, Timothy A. Fritz, Lawrence A. Tabak, Christine E. Seidman, Adriaan G. Holleboom, Ron A. Wevers, Jeroen A. Sierts, Mats Lindahl, G. Kees Hovingh
Publikováno v: Cell metabolism, 14(6), 811-818. Cell Press
Cell metabolism, 14(6), 811-818. CELL PRESS
Cell Metabolism, 14, 6, pp. 811-8
CELL METABOLISM, 14(6), 811-818
Cell Metabolism, 14, 811-8
Item does not contain fulltext Genome-wide association studies have identified GALNT2 as a candidate gene in lipid metabolism, but it is not known how the encoded enzyme ppGalNAc-T2, which contributes to the initiation of mucin-type O-linked glycosyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3eee28c011254c8aba1d859939c48fe
https://doi.org/10.1016/j.cmet.2011.11.005
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2
Genetic Variant of the Scavenger Receptor BI in Humans
Autor: Theo J.C. Van Berkel, John J.P. Kastelein, Jeroen A. Sierts, M. Mahdi Motazacker, Ruud Out, Suzanne J.A. Korporaal, Menno Vergeer, G. Kees Hovingh, Geesje M. Dallinga-Thie, Jan Albert Kuivenhoven, Menno Hoekstra, Remco Franssen, Miranda Van Eck, Adriaan G. Holleboom, Illiana Meurs
Publikováno v: New England journal of medicine, 364(2), 136-145. Massachussetts Medical Society
New England Journal of Medicine, 364(2), 136-45. MASSACHUSETTS MEDICAL SOC
BACKGROUND: In mice, the scavenger receptor class B type I (SR-BI) is essential for the delivery of high-density lipoprotein (HDL) cholesterol to the liver and steroidogenic organs. Paradoxically, elevated HDL cholesterol levels are associated with i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5600888a106df85bf238c1152b5c19
https://doi.org/10.1056/nejmoa0907687
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3
Chylomicronemia With Low Postheparin Lipoprotein Lipase Levels in the Setting of GPIHBP1 Defects
Autor: Stephen G. Young, Geesje M. Dallinga-Thie, Anne P. Beigneux, Jozef Hertecant, Frank Peelman, John J.P. Kastelein, André Bensadoun, Jeroen A. Sierts, Alinda W. M. Schimmel, Remco Franssen, Loren G. Fong
Publikováno v: Circulation. Cardiovascular genetics, 3(2), 169-178. Lippincott Williams and Wilkins
Background— Recent studies in mice have established that an endothelial cell protein, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), is essential for the lipolytic processing of triglyceride-rich lipopro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f29cc6ffd0c4851188cecbe7db0df6
https://doi.org/10.1161/circgenetics.109.908905
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4
Efficient lowering of triglyceride levels in mice by human apoAV protein variants associated with hypertriglyceridemia
Autor: Jeroen A. Sierts, Stefan F C Vaessen, Frank G. Schaap, Jan Albert Kuivenhoven
Publikováno v: Biochemical and biophysical research communications, 379(2), 542-546. Academic Press Inc.
Variation in the apolipoprotein A5 (APOA5) gene has consistently been associated with increased plasma triglyceride (TG) levels in epidemiological studies. In vivo functionality of these variations, however, has thus far not been tested. Using adenov
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527371c639435c02b11741e00543d10d
https://doi.org/10.1016/j.bbrc.2008.12.115
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5
Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice
Autor: John J.P. Kastelein, Stefan F C Vaessen, Jeroen A. Sierts, Jaap Rip, Jan Albert Kuivenhoven, Jaap Twisk
Publikováno v: Atherosclerosis, 194(1), 55-61. Elsevier Ireland Ltd
BACKGROUND: Overexpression of lipoprotein lipase (LPL) protects against atherosclerosis in genetically engineered mice. We tested whether a gene therapy vector that delivers human (h) LPL(S447X) cDNA to skeletal muscle could induce similar effects. M
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714fd1ee301465dcb5c4d4d10b14827e
https://doi.org/10.1016/j.atherosclerosis.2006.09.023
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6
Lipoprotein profiles in human heterozygote carriers of a functional mutation P297S in scavenger receptor class B1
Autor: Christina Gkolfinopoulou, Mats Lindahl, Kees Hovingh, Menno Vergeer, Jeroen A. Sierts, Jan Albert Kuivenhoven, Helen Karlsson, Stefan Ljunggren, John J.P. Kastelein, Johannes H.M. Levels, Letta Argyri, Adriaan G. Holleboom, Angeliki Chroni
Publikováno v: Biochimica et biophysica acta-Molecular and cell biology of lipids, 1851(12), 1587-1595. ELSEVIER SCIENCE BV
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1851(12), 1587-1595. Elsevier
The scavenger receptor class B type 1 (SR-B1) is an important HDL receptor involved in cholesterol uptake and efflux, but its physiological role in human lipoprotein metabolism is not fully understood. Heterozygous carriers of the SR-B1P297S mutation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f822d6de9f48d669503f697622c6458
https://pubmed.ncbi.nlm.nih.gov/26454245
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7
AAV1-LPLS447X gene therapy reduces hypertriglyceridemia in apoE2 knock in mice
Autor: Jaap Twisk, Ko Willems van Dijk, John J.P. Kastelein, Jan Albert Kuivenhoven, Jeroen A. Sierts, Jaap Rip
Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1761(10), 1163-1168. Elsevier
Intramuscular (IM) application of adeno-associated virus serotype 1 (AAV1) for the delivery of human lipoprotein lipase (hLPL) was previously shown efficacious in mice with chylomicronemia. The current study addresses whether AAV1-LPL(S447X) can redu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda0725cdd2297e6a21d19575f71fdd7
https://doi.org/10.1016/j.bbalip.2006.08.008
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8
AAV gene therapy as a means to increase apolipoprotein (Apo) A-I and high-density lipoprotein-cholesterol levels: correction of murine ApoA-I deficiency
Autor: Elisabeth M Comijn, Karin van den Oever, Stefan F C Vaessen, Jeroen A. Sierts, Robert Jan Veldman, Jolanda Snapper, Stuart G. Beattie, Jaap Twisk, Jan Albert Kuivenhoven
Publikováno v: journal of gene medicine, 11(8), 697-707. John Wiley and Sons Ltd
Journal of gene medicine, 11(8), 697-707. Wiley
BACKGROUND: Inherited apolipoprotein (Apo) A-I deficiency is an orphan disorder characterized by high-density lipoprotein (HDL)-cholesterol deficiency and premature atherosclerosis. Constitutive over-expression of ApoA-I might provide a means to trea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5084ff4f6ce01a02388af54496897000
https://pure.amc.nl/en/publications/aav-gene-therapy-as-a-means-to-increase-apolipoprotein-apo-ai-and-highdensity-lipoproteincholesterol-levels-correction-of-murine-apoai-deficiency(5d32bf76-dad0-4638-9c29-58bd760871f8).html
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10
Gene Therapy for Lipoprotein Lipase Deficiency: Working Toward Clinical Application
Autor: Janneke M. Meulenberg, Karin van den Oever, Erik S.G. Stroes, Melchior C. Nierman, John J.P. Kastelein, Jaap Twisk, Michael R. Hayden, Colin J. D. Ross, Wim T. J. M. C. Hermens, Jeroen A. Sierts, Andrew C. Bakker, Jaap Rip, Daniël H. van Raalte, Jan Albert Kuivenhoven, Paul A. Dijkhuizen, Wilma Petersen
Publikováno v: Human gene therapy, 16(11), 1276-1286. Mary Ann Liebert Inc.
Lipoprotein lipase (LPL) deficiency causes hypertriglyceridemia and recurrent, potentially life- threatening pancreatitis. There currently is no adequate treatment for this disease. Previously, we showed that intramuscular administration of an adeno-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7937eded623136b0af482c225c7909d4
https://doi.org/10.1089/hum.2005.16.ft-138
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