Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Jeroen, Kool"'
Autor:
Mátyás A. Bittenbinder, Flavio Bonanini, Dorota Kurek, Paul Vulto, Jeroen Kool, Freek J. Vonk
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Snakebite envenomation is a major public health issue which causes severe morbidity and mortality, affecting millions of people annually. Of a diverse range of clinical manifestations, local and systemic haemorrhage are of particular relevan
Externí odkaz:
https://doaj.org/article/e8ede00d4f004af3b762a210dd0dc76f
Autor:
Mátyás A. Bittenbinder, Jory van Thiel, Fernanda C. Cardoso, Nicholas R. Casewell, José-María Gutiérrez, Jeroen Kool, Freek J. Vonk
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Snakebite envenoming is an important public health issue responsible for mortality and severe morbidity. Where mortality is mainly caused by venom toxins that induce cardiovascular disturbances, neurotoxicity, and acute kidney injury, morbid
Externí odkaz:
https://doaj.org/article/2910b669ced54e10874f3a1cec175594
Autor:
Mátyás A. Bittenbinder, Eric Wachtel, Daniel Da Costa Pereira, Julien Slagboom, Nicholas R. Casewell, Paul Jennings, Jeroen Kool, Freek J. Vonk
Publikováno v:
Toxicon: X, Vol 22, Iss , Pp 100197- (2024)
Snakebite envenoming is a global health issue that affects millions of people worldwide, and that causes morbidity rates surpassing 450,000 individuals annually. Patients suffering from snakebite morbidities may experience permanent disabilities such
Externí odkaz:
https://doaj.org/article/ac6aba6cfeab4a96a279562411acc225
Autor:
Steven R. Hall, Sean A. Rasmussen, Edouard Crittenden, Charlotte A. Dawson, Keirah E. Bartlett, Adam P. Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R. Casewell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms. Repurposed small mo
Externí odkaz:
https://doaj.org/article/e9078a0bbeb241e9a8145f4cb4841a67
Autor:
Mátyás A. Bittenbinder, Flavio Bonanini, Dorota Kurek, Paul Vulto, Jeroen Kool, Freek J. Vonk
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/d6aacfd11b42448f8f52b02f6dd260de
Autor:
Julien Slagboom, Abigail H. Lewis, Wietse M. Schouten, Rien van Haperen, Mieke Veltman, Mátyás A. Bittenbinder, Freek J. Vonk, Nicholas R. Casewell, Frank Grosveld, Dubravka Drabek, Jeroen Kool
Publikováno v:
Toxicon: X, Vol 21, Iss , Pp 100185- (2024)
Snakebite envenoming is a priority Neglected Tropical Disease that causes an estimated 81,000–135,000 fatalities each year. The development of a new generation of safer, affordable, and accessible antivenom therapies is urgently needed. With this g
Externí odkaz:
https://doaj.org/article/aa72a3429ba844ee87def2003bd12c3d
Autor:
Haifeng Xu, Susan El-Asal, Hafsa Zakri, Rama Mutlaq, Natascha T. B. Krikke, Nicholas R. Casewell, Julien Slagboom, Jeroen Kool
Publikováno v:
Toxins, Vol 16, Iss 9, p 379 (2024)
Snakebite is a serious health issue in tropical and subtropical areas of the world and results in various pathologies, such as hemotoxicity, neurotoxicity, and local swelling, blistering, and tissue necrosis around the bite site. These pathologies ma
Externí odkaz:
https://doaj.org/article/f960ed61b658483b92275372ca9ec5ed
Autor:
Haifeng Xu, Jesse Mastenbroek, Natascha T. B. Krikke, Susan El-Asal, Rama Mutlaq, Nicholas R. Casewell, Julien Slagboom, Jeroen Kool
Publikováno v:
Toxins, Vol 16, Iss 8, p 370 (2024)
Worldwide, it is estimated that there are 1.8 to 2.7 million cases of envenoming caused by snakebites. Snake venom is a complex mixture of protein toxins, lipids, small molecules, and salts, with the proteins typically responsible for causing patholo
Externí odkaz:
https://doaj.org/article/1612c90600294f029906cff47b513f1b
Publikováno v:
Toxins, Vol 16, Iss 7, p 300 (2024)
Envenoming resulting from snakebites is recognized as a priority neglected tropical disease by The World Health Organization. The Bothrops genus, consisting of different pitviper species, is considered the most medically significant taxa in Central a
Externí odkaz:
https://doaj.org/article/912b6f11b53c46fb82a89d7ee432bcaf
Autor:
Laura-Oana Albulescu, Adam Westhorpe, Rachel H. Clare, Christopher M. Woodley, Nivya James, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors
Externí odkaz:
https://doaj.org/article/e44e33036d7043608452939fe49851f5