Cluster Analysis of Endogenous HER2 and HER3 Receptors in SKBR3 Cells

Autor: Selene Roberts, Michael Hirsch, Alexandra McStea, Laura Zanetti-Domingues, David Clarke, Jeroen Claus, Peter Parker, Lin Wang, Marisa Martin-Fernandez

Publikováno v: Bio-Protocol, Vol 8, Iss 23 (2018)

The Human Epidermal Growth Factor Receptor (HER) family of receptor tyrosine kinases consists of four, single pass, transmembrane receptor homologs (HER1-4) that act to regulate many critical processes in normal and tumor cells. HER2 is overexpressed

Externí odkaz: https://doaj.org/article/8c5533c0d7f745aaa90ef476b7b2a1db

Targeting the HER3 pseudokinase domain with small molecule inhibitors

Autor: Audrey, Colomba, Jeroen, Claus, Forson, Gao, Roger, George, Arianna, Fornili, Angus J M, Cameron

Publikováno v: Methods in enzymology. 667

HER3 is a potent oncogenic growth factor receptor belonging to the human epidermal growth factor (HER/EGFR) family of receptor tyrosine kinases. In contrast to other EGFR family members, HER3 is a pseudokinase, lacking functional kinase activity. As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0b81be09da489620b74f409b8738f27
https://pubmed.ncbi.nlm.nih.gov/35525551

Targeting the HER3 pseudokinase domain with small molecule inhibitors

Autor: Audrey Colomba, Jeroen Claus, Forson Gao, Roger George, Arianna Fornili, Angus J.M. Cameron

Publikováno v: Methods in Enzymology ISBN: 9780323915410

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cb4ce2c96d0f3f7e1bbc99f2bc6d451
https://doi.org/10.1016/bs.mie.2022.03.044

Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

Autor: Paul R. Barber, Yosef Yarden, Roger George, Gargi Patel, Flavia Autore, Boris Vojnovic, Gregory Weitsman, Audrey Colomba, Marisa L. Martin-Fernandez, Selene K. Roberts, Peter J. Parker, Laura C. Zanetti-Domingues, Tony Ng, Michael Hirsch, Francesca Collu, Angus J.M. Cameron, Franca Fraternali, Tanya N. Soliman, Elena Ortiz-Zapater, Jeroen Claus

Publikováno v: Claus, J, Patel, G, Autore, F, Colomba, A, Weitsman, G, Soliman, T N, Roberts, S, Zanetti Domingues, L C, Hirsch, M, Collu, F, George, R, Ortiz-Zapater, E, Barber, P R, Vojnovic, B, Yarden, Y, Martin-Fernandez, M L, Cameron, A, Fraternali, F, Ng, T & Parker, P J 2018, ' Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface ', eLife, vol. 7, e32271 . https://doi.org/10.7554/eLife.32271
eLife
eLife, Vol 7 (2018)

While targeted therapy against HER2 is an effective first-line treatment in HER2+ breast cancer, acquired resistance remains a clinical challenge. The pseudokinase HER3, heterodimerisation partner of HER2, is widely implicated in the resistance to HE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710cfdc7ac40e5df3cb72c57279b1b1a
https://doi.org/10.7554/elife.32271

Regulation of the cytokinesis cleavage furrow by PKCε

Autor: Nicola Brownlow, Peter J. Parker, Tanya Pike, Jeroen Claus, Victoria Crossland

Publikováno v: Biochemical Society Transactions. 42:1534-1537

Cytokinesis is the final act of the cell cycle where the replicated DNA and cellular contents are finally split into two daughter cells. This process is very tightly controlled as DNA segregation errors and cytokinesis failure is commonly associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2921c5ae48fb5ae907b6a02ca0e09a67
https://doi.org/10.1042/bst20140240